| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 99-76-3 |
| ECHA EC Number: | 202-785-7 |
| FDA UNII: | A2I8C7HI9T |
| Category: | antioxidants and preservatives |
| IUPAC Name: | methyl paraben |
| InChI : | InChI=1/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3 |
| Std.InChI: | InChI=1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3 |
| InChIKey : | LXCFILQKKLGQFO-UHFFFAOYAH |
| Std.InChIKey: | LXCFILQKKLGQFO-UHFFFAOYSA-N |
| SMILES : | COC(=O)C1=CC=C(C=C1)O |
| MDL: | MFCD00002352 |
| Molar Refractivity : | 39.90 ± 0.3 cm3 (est) |
| Parachor : | 327.1 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.547 ± 0.02 (est) |
| Surface Tension : | 45.7 ± 3.0 dyne/cm (est) |
| Density : | 1.209 ± 0.06 g/cm3 (est) |
| Polarizability : | 15.82 ± 0.5 10-24cm3 (est) |
| Appearance: | white crystalline powder (est) |
| Assay: | 99.00 to 100.00 |
| Food Chemicals Codex Listed: | Yes |
| Melting Point: | 125.00 to 128.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 275.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.006000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 241.00 °F. TCC ( 116.11 °C. ) |
| logP (o/w): | 1.960 |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: | |
| alcohol | |
| water, 5981 mg/L @ 25 °C (est) | |
| ether | |
| propylene glycol | |
| water, 2500 mg/L @ 25 °C (exp) | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | preservatives |
| Acme-Hardesty |
| Methyl Paraben Odor: characteristic Use: Antimicrobial Preservative Used in Cosmetics and Personal Care. |
| Alfa Biotechnology |
| For experimental / research use only. |
| Methylparaben 98% |
| BOC Sciences |
| For experimental / research use only. |
| Methyl 4-hydroxybenzoate |
| Charkit Chemical |
| METHYL PARABEN NF |
| ECSA Chemicals |
| METHYL PARABEN |
| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| EMD Millipore |
| For experimental / research use only. |
| Methyl 4-hydroxybenzoate |
| ExtraSynthese |
| For experimental / research use only. |
| Methyl-4-hydroxybenzoate (GC) ≥99% |
| Foodchem International |
| Methyl Paraben |
| Glentham Life Sciences |
| Methyl 4-hydroxybenzoate, Ph. Eur. grade |
| HallStar |
| CoSept(tm) M Odor: characteristic Use: CoSept M is an extra fine white powder with faint odor that is non-hygroscopic and generally recognized as safe (GRAS) for use as a preservative in foods. For over 50 years this neutral ester of para-hydroxybenzoic acid has functioned as an excellent bacteriostatic and fungistatic agent at low concentration against a wide range of organisms. It is stable and active from pH 3 to 8, and is often used in conjunction with other additives (e.g., EDTA or its salts, Quaternium-15, Diazolidinyl Urea, Propylparaben) for synergistic effects. In personal care products, CoSept M and CoSept P have typically been used in combination (0.2% Methylparaben and 0.1% Propylparaben, with levels adjusted to specific circumstances). CoSept M has limited solubility in water, so presolubilization can reduce dissolution time and therefore batching time. The preference for parabens continues due to their 50-year history of safety and reliability. |
| HallStar |
| METHYL PARABEN Odor: characteristic Use: Methyl Paraben is an extra fine white powder with faint odor that is non-hygroscopic and generally recognized as safe (GRAS) for use as a preservative in foods. For over 50 years this neutral ester of para-hydroxybenzoic acid has functioned as an excellent bacteriostatic and fungistatic agent at low concentration against a wide range of organisms. It is stable and active from pH 3 to 8, and is often used in conjunction with other additives (e.g., EDTA or its salts, Quaternium-15, Diazolidinyl Urea, Propylparaben) for synergistic effects. In personal care products, Methylparaben and Propylparaben have typically been used in combination (0.2% Methylparaben and 0.1% Propylparaben, with levels adjusted to specific circumstances). Methyl Paraben has limited solubility in water, so presolubilization can reduce dissolution time and therefore batching time. The preference for parabens continues due to their 50-year history of safety and reliability. |
| Indis NV |
| For experimental / research use only. |
| Methyl Paraben |
| Kingyoung Bio Technical |
| Methylparaben |
| Kraft Chemical |
| Methyl Paraben |
| Nanjing Jiancheng Chemical |
| Methylparaben(Nipagin) Odor: characteristic Use: Methylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives. With excellent biological degradation function, it is a highly efficient emulsification stabilizer. |
| Penta International |
| METHYL-4-HYDROXYBENZOATE FCC |
| Penta International |
| METHYL-P-HYDROXYBENZOATE NF - EP GRADE |
| Penta International |
| METHYL-P-HYDROXYBENZOATE NF |
| Penta International |
| METHYL-p-HYDROXYBENZOATE |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Methyl Paraben |
| Shiva Chemicals and Pharmaceuticals |
| Methyl Parabean |
| Sigma-Aldrich |
| Methyl 4-hydroxybenzoate, ≥99%, FCC |
| Certified Food Grade Products |
| Sinofi Food Ingredients |
| Methylparaben Odor: characteristic Use: Preservative, Cosmetics, Feed, Pharmaceutical, Antimicrobial, Antifungal, Antibacterial, Soft Drink, Alcohol Beverage, Beverage Powder, Fruit Juice, Puddings, Sauces, Baking Food, Sauage, Food Colors, Milk, Wine, Flavoring Agent. |
| TCI AMERICA |
| For experimental / research use only. |
| Methyl 4-Hydroxybenzoate >99.0%(HPLC)(T) |
| TRI-K Industries |
| TRIsept M (USP/NF/BP) Odor: characteristic Use: A widely used, effectual, cost effective cosmetic preservative. |
| Zhong Ya Chemical |
| Methyl Parabens (India) |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| intraperitoneal-mouse LD50 960 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ATAXIAPERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. oral-guinea pig LD50 3000 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. oral-mouse LD50 > 8000 mg/kg BEHAVIORAL: ATAXIAPERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. oral-rabbit LD50 6000 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974. | |
| Dermal Toxicity: | |
| subcutaneous-mouse LD50 1200 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960. subcutaneous-rat LD50 > 500 mg/kg Clinical Toxicology. Vol. 4(2), Pg. 185, 1971. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| antioxidants and preservatives | |||
| Recommendation for methyl paraben usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 5.00000 | 8.00000 | |
| beverages(nonalcoholic): | - | 5.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 5.00000 | |
| fruit ices: | - | 5.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 5.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):99-76-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :7456 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| methyl 4-hydroxybenzoate |
| Chemidplus:0000099763 |
| RTECS:DH2450000 for cas# 99-76-3 |
| methyl 4-hydroxybenzoate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 99-76-3 |
| Pubchem (cid): | 7456 |
| Pubchem (sid): | 134972055 |
| Pherobase: | View |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | D01400 |
| HMDB (The Human Metabolome Database): | HMDB32572 |
| FooDB: | FDB010509 |
| Export Tariff Code: | 2918.29.7500 |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •topical antibiotic or corticosteroid preparations usually contain 0.3% parabens; however, ointments of tetracyclines contain 3% and some surgical powders of tetracyclines contain as much as 20% parabens. parabens•methylparaben usp methylparaben and propylparaben solution (preserved water)•grade: united states pharmacopeia, "food chemical codex"•the esters are usually dissolved in boiling water and then added to prepn, but when no water is present in formula they may be dissolved in alcohol, acetone, triethanolamine, glycerin, perfume oils, or melted fats. parabens•a combination of 0.18% methylparaben and 0.02% propylparaben is approved for use as preservative for certain parenteral solutions, eg, aq procaine penicillin suspensions.•trade names: abiol, aseptoform, maseptol, metaben, methaben, methyl butex, methyl chemosept, methyl parasept, methylben, metoxyde, moldex, nipagin, nipagin m, paridol, preserval, septos, solbrol, solbrol m, and tegosept m. | |
| None Found |
| preservatives |
| aseptoform | |
| benzoic acid, 4-hydroxy-, methyl ester | |
| benzoic acid, p-hydroxy-, methyl ester | |
| 4-( | carbomethoxy)phenol |
| p- | carbomethoxyphenol |
| para- | carbomethoxyphenol |
| 4- | hydroxy methyl benzoate |
| 4- | hydroxy-benzoic acid methyl ester |
| 4- | hydroxybenzoic acid methyl ester |
| p- | hydroxybenzoic acid methyl ester |
| para- | hydroxybenzoic acid methyl ester |
| 4- | hydroxybenzoic acid methylester |
| 4- | hydroxybenzoic acid, methyl ester |
| p- | hydroxybenzoic acid, methyl ester |
| p- | hydroxybenzoic methyl ester |
| killitol | |
| maseptol | |
| mekkings M | |
| metaben | |
| metagin | |
| methaben | |
| p- | methoxycarbonyl phenol |
| para- | methoxycarbonyl phenol |
| 4-( | methoxycarbonyl) phenol |
| 4-( | methoxycarbonyl)phenol |
| p- | methoxycarbonylphenol |
| methyl 4-hydroxybenzoate | |
| methyl butex | |
| methyl chemosept | |
| methyl ester of p-hydroxybenzoic acid | |
| methyl p-hydroxybenzoate | |
| methyl p-oxybenzoate | |
| methyl para-hydroxybenzoate | |
| methyl para-oxybenzoate | |
| methyl parabens (india) | |
| methyl parasept | |
| methyl-4-hydroxybenzoate | |
| methyl-4-hydroxybenzoate FCC | |
| methyl-p-hydroxybenzoate | |
| methyl-p-hydroxybenzoate NF | |
| methylben | |
| methylparaben | |
| metoxyde | |
| moldex | |
| nipagin | |
| para M | |
| paradol | |
| paridol | |
| preserval | |
| solbrol | |
| tegosept |
