| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 99-06-9 |
| ECHA EC Number: | 202-726-5 |
| FDA UNII: | 2ZFW40OJ7U |
| Category: | stabilizing agents |
| IUPAC Name: | meta-salicylic acid |
| InChI : | InChI=1/C7H6O3/c8-6-3-1-2-5(4-6)7(9)10/h1-4,8H,(H,9,10) |
| Std.InChI: | InChI=1S/C7H6O3/c8-6-3-1-2-5(4-6)7(9)10/h1-4,8H,(H,9,10) |
| InChIKey : | IJFXRHURBJZNAO-UHFFFAOYAV |
| Std.InChIKey: | IJFXRHURBJZNAO-UHFFFAOYSA-N |
| SMILES : | C1=CC(=CC(=C1)O)C(=O)O |
| MDL: | MFCD00002506 |
| Molar Refractivity : | 35.06 ± 0.3 cm3 (est) |
| Parachor : | 284.4 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.615 ± 0.02 (est) |
| Surface Tension : | 64.4 ± 3.0 dyne/cm (est) |
| Density : | 1.375 ± 0.06 g/cm3 (est) |
| Polarizability : | 13.90 ± 0.5 10-24cm3 (est) |
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| DG SANTE Food Flavourings: | 08.132 3-hydroxybenzoic acid |
| FEMA Number: | 4431 3-hydroxybenzoic acid |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 99-06-9 ; 3-HYDROXYBENZOIC ACID |
| Appearance: | white powder (est) |
| Assay: | 99.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 202.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 345.00 to 346.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.000022 mmHg @ 25.00 °C. (est) |
| Flash Point: | 351.00 °F. TCC ( 177.22 °C. ) |
| logP (o/w): | 1.500 |
| Soluble in: | |
| alcohol | |
| water, 1.697e+004 mg/L @ 25 °C (est) | |
| water, 7250 mg/L @ 25 °C (exp) | |
| Insoluble in: | |
| water | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | skin conditioning |
| BOC Sciences |
| For experimental / research use only. |
| 3-Hydroxybenzoic Acid |
| ExtraSynthese |
| For experimental / research use only. |
| 3-Hydroxybenzoic acid (HPLC) ≥90% |
| Glentham Life Sciences |
| 3-Hydroxybenzoic acid |
| Penta International |
| 3-HYDROXYBENZOIC ACID |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 3-Hydroxybenzoic acid |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 3-Hydroxybenzoic acid ReagentPlus®, 99% |
| TCI AMERICA |
| For experimental / research use only. |
| 3-Hydroxybenzoic Acid >98.0%(LC)(T) |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-mouse LD50 2000 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 483, 1946. intraperitoneal-rat LD50 3700 mg/kg Bollettino Chimico Farmaceutico. Vol. 112, Pg. 53, 1973. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| stabilizing agents | |||
| Recommendation for meta-salicylic acid usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 610.00 (μg/capita/day) | ||
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 120000 (μg/person/day) | ||
| Threshold of Concern: | 1800 (μg/person/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 24 | |||
| Click here to view publication 24 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | - | |
| beverages(nonalcoholic): | 300.00000 | 500.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 500.00000 | 2000.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | 300.00000 | 500.00000 | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | 300.00000 | 500.00000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). | |||
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. | |||
| average usage mg/kg | maximum usage mg/kg | ||
| Dairy products, excluding products of category 02.0 (01.0): | - | - | |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | - | - | |
| Edible ices, including sherbet and sorbet (03.0): | - | - | |
| Processed fruit (04.1): | - | - | |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - | |
| Confectionery (05.0): | 500.00000 | 2000.00000 | |
| Chewing gum (05.3): | - | - | |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | - | - | |
| Bakery wares (07.0): | - | - | |
| Meat and meat products, including poultry and game (08.0): | - | - | |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | - | - | |
| Eggs and egg products (10.0): | - | - | |
| Sweeteners, including honey (11.0): | - | - | |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | - | - | |
| Foodstuffs intended for particular nutritional uses (13.0): | - | - | |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 300.00000 | 500.00000 | |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 300.00000 | 500.00000 | |
| Ready-to-eat savouries (15.0): | - | - | |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | - | - | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 4 (FGE.20Rev4): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):99-06-9 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :7420 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| 3-hydroxybenzoic acid |
| Chemidplus:0000099069 |
| RTECS:DH1924980 for cas# 99-06-9 |
| 3-hydroxybenzoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 7420 |
| Pubchem (sid): | 134971601 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00587 |
| HMDB (The Human Metabolome Database): | HMDB02466 |
| FooDB: | FDB010507 |
| Export Tariff Code: | 2918.29.1000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| None Found |
| skin conditioning |
| benzoic acid, 3-hydroxy- | |
| benzoic acid, m-hydroxy- | |
| 3- | hydroxy benzoic acid |
| m- | hydroxy benzoic acid |
| meta- | hydroxy benzoic acid |
| 3- | hydroxy-benzoic acid |
| m- | hydroxy-benzoic acid |
| 3- | hydroxybenzoic acid |
| m- | hydroxybenzoic acid |
| meta- | hydroxybenzoic acid |
| 3- | hydroxybenzoic aicd |
| 3- | hydroxybenzoicacid |
| m- | hydroxylbenzoic acid |
| 3- | salicylic acid |
| m- | salicylic acid |
| meta- | salicylic acid |
| m- | salicylicacid |
