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scutellaria baicalensis root extract

astringents
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CAS Number: 94279-99-9
FDA UNII: Search
Category: astringents
IUPAC Name: scutellaria baicalensis root extract

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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FEMA Number:4975
FDA:No longer provide for the use of these seven synthetic flavoring substances

Physical Properties:

Food Chemicals Codex Listed: No

Cosmetic Information:

CosIng:cosmetic data
Cosmetic Uses: astringents
humectants
soothing agents

Suppliers:

BOC Sciences
For experimental / research use only.
Scutellaria Baicalensis Root Extract 95%
Plant Extracts
Scutellaria Baicalensis Extract
Shaanxi Y-Herb Biotechnology
Scutellaria Baicalensis Root Extract 85% 98% Baical Skullcap P.E Baicalin Powder
Xi'an Greena Biotech
Scutellaria Baicalensis Extract
Odor: characteristic
Use: Scutellaria baicalensis, also known as Baical skullcap root ,Huang Qin,Baical or Chinese Scutellaria, or Scullcap.It is mainly produced in Hebei, Shanxi, Inner Mongolia, Henan, Shaanxi and other places in China.Usually it is harvested during spring and autumn.Scutellaria baicalensis georgi from the Lamiaceae family is said to be one of the potent medicinal herbs and is thus used to treat a number of health disorders for over two thousand years.Scutellaria baicalensis root contains compounds including baicalein,neobaicalein,baicalin,wogonin,wogono-side,oroxylin,oroxylin A,etc active ingredients.

Safety Information:

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
astringents
Recommendation for scutellaria baicalensis root extract usage levels up to:
not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 30
Click here to view publication 30
average usual ppmaverage maximum ppm
baked goods: 200.00000300.00000
beverages(nonalcoholic): 100.00000200.00000
beverages(alcoholic): 100.00000200.00000
breakfast cereal: 200.00000300.00000
cheese: --
chewing gum: 100.00000200.00000
condiments / relishes: 100.00000200.00000
confectionery froastings: 100.00000200.00000
egg products: 100.00000200.00000
fats / oils: --
fish products: --
frozen dairy: 200.00000300.00000
fruit ices: 100.00000200.00000
gelatins / puddings: 100.00000200.00000
granulated sugar: --
gravies: 200.00000300.00000
hard candy: 200.00000300.00000
imitation dairy: 200.00000300.00000
instant coffee / tea: 100.00000200.00000
jams / jellies: 100.00000200.00000
meat products: 100.00000200.00000
milk products: 200.00000300.00000
nut products: 200.00000400.00000
other grains: 200.00000300.00000
poultry: --
processed fruits: 100.00000200.00000
processed vegetables: 100.00000200.00000
reconstituted vegetables: 200.00000400.00000
seasonings / flavors: 300.00000500.00000
snack foods: 100.00000200.00000
soft candy: 200.00000300.00000
soups: 200.00000300.00000
sugar substitutes: 200.00000300.00000
sweet sauces: 200.00000400.00000

Safety References:

ClinicalTrials.gov:search
AIDS Citations:Search
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EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
scutellaria baicalensis root extract
Chemidplus:0094279999

References:

scutellaria baicalensis root extract
Canada Domestic Sub. List:94279-99-9
Pubchem (sid):135316960

Other Information:

Wikipedia:View

Potential Blenders and core components :

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):

skullcap baikal skullcap root
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Synonyms:

extract of the roots of the scutellaria baicalensis, lamiaceae
hoodwort root extract
scutellaria lanceolaria root extract
scutellaria macrantha root extract
baikal skullcap root extract
blue skullcap root extract
chinese skullcap root extract
maddog skullcap root extract

Articles:

PubMed:The effects of the standardized herbal formula PM014 on pulmonary inflammation and airway responsiveness in a murine model of cockroach allergen-induced asthma.
PubMed:Baicalein pretreatment confers cardioprotection against acute myocardial infarction by activating the endothelial nitric oxide synthase signaling pathway and inhibiting oxidative stress.
PubMed:Bone marrow microenvironment confers imatinib resistance to chronic myelogenous leukemia and oroxylin A reverses the resistance by suppressing Stat3 pathway.
PubMed:Wogonin-enhanced reactive oxygen species-induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2-mediated signaling in HepG2 cells.
PubMed:Oroxylin A inhibits hypoxia-induced invasion and migration of MCF-7 cells by suppressing the Notch pathway.
PubMed:[Physiological ecology responses of Scutellaria baicalensis to drought and rewatering].
PubMed:Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats.
PubMed:Synthesis and biological evaluation of baicalein derivatives as potent antitumor agents.
PubMed:Baicalin protects PC-12 cells from oxidative stress induced by hydrogen peroxide via anti-apoptotic effects.
PubMed:Purification and antioxidant activities of baicalin isolated from the root of huangqin (Scutellaria baicalensis gcorsi).
PubMed:Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots.
PubMed:Cloning and characterization of a cDNA encoding calcium/calmodulin-dependent glutamate decarboxylase from Scutellaria baicalensis.
PubMed:Probe substrate and enzyme source-dependent inhibition of UDP-glucuronosyltransferase (UGT) 1A9 by wogonin.
PubMed:Chronic administration of baicalein decreases depression-like behavior induced by repeated restraint stress in rats.
PubMed:Baicalin inhibits Staphylococcus aureus-induced apoptosis by regulating TLR2 and TLR2-related apoptotic factors in the mouse mammary glands.
PubMed:[Study on transport mechanism of baicalin in Scutellariae radix extracts and effect of Angelica dahurica extracts on transport of baicalin by Caco-2 cell monolayer model].
PubMed:Wogonin influences vascular permeability via Wnt/β-catenin pathway.
PubMed:[Study on rapid propagation of Scutellaria baicalensis variation].
PubMed:Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones in Radix Scutellariae and potential pharmacological impact.
PubMed:Inhibitory effects of baicalin in the early stage of 3T3-L1 preadipocytes differentiation by down-regulation of PDK1/Akt phosphorylation.
PubMed:[Study on HPLC-fingerprint-based identification of dao-di herb and non dao-di herb of scutellariae radix].
PubMed:Scutellariae radix suppresses LPS-induced liver endothelial cell activation and inhibits hepatic stellate cell migration.
PubMed:Baicalein, an active component of Scutellaria baicalensis Georgi, induces apoptosis in human colon cancer cells and prevents AOM/DSS-induced colon cancer in mice.
PubMed:Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury.
PubMed:Baicalein selectively induces apoptosis in activated lymphocytes and ameliorates concanavalin a-induced hepatitis in mice.
PubMed:Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis.
PubMed:Assessment of dermal safety of Scutellaria baicalensis aqueous extract topical application on skin hypersensitivity.
PubMed:[Effect of different developmental stage on plant growth and active compounds in Scutellaria baicalensis].
PubMed:Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice.
PubMed:Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells.
PubMed:Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells.
PubMed:Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest.
PubMed:[Effects of plant growth regulator mepiquat chloride on content of active compounds in Scutellaria baicalensis].
PubMed:Baicalin regulates neuronal fate decision in neural stem/progenitor cells and stimulates hippocampal neurogenesis in adult rats.
PubMed:The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells.
PubMed:[Effect of Scutellaria baicalensis root extract on cytogenetic damage induced by paclitaxel and cisplatin in mice].
PubMed:Wogonin inhibits H2O2-induced vascular permeability through suppressing the phosphorylation of caveolin-1.
PubMed:Baicalein protects against cardiac hypertrophy through blocking MEK-ERK1/2 signaling.
PubMed:[Responses of Scutellaria baicalensis Georgi yield and root baicalin content to the fertilization rates of nitrogen, phosphorus, and potassium].
PubMed:Baicalein inhibits DMBA/TPA-induced skin tumorigenesis in mice by modulating proliferation, apoptosis, and inflammation.
PubMed:Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway.
PubMed:[Research on relationship between commercial specifications of Scutellariae Radix and chemical composition and drug quality].
PubMed:Wogonin potentiates cisplatin-induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species.
PubMed:[Effects of three fungicides on arbuscular mycorrhizal fungal infection and growth of Scutellaria baicalensis Georgi].
PubMed:Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response.
PubMed:Flavonoids and antioxidative enzymes in temperature-challenged roots of Scutellaria baicalensis Georgi.
PubMed:Relaxant effect induced by wogonin from Scutellaria baicalensis on rat isolated uterine smooth muscle.
PubMed:Baicalin is anti-inflammatory in cigarette smoke-induced inflammatory models in vivo and in vitro: A possible role for HDAC2 activity.
PubMed:A simple isocratic HPLC method for the simultaneous determination of bioactive components of Scutellariae radix extract.
PubMed:Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism.
PubMed:Pharmacokinetic study of baicalein after oral administration in monkeys.
PubMed:[Analysis of the content of mineral elements in Scutellaria baicalensis, skullcap tea and its solution].
PubMed:Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives.
PubMed:Effect of baikal skullcap root (Scutellaria baicalensis radix) on cholesterol level and meat quality in rabbits fed a cholesterol rich diet.
PubMed:[Effects of AM fungi on growth and microelement of Scuteliaria baiealensis under different applied phosphorous levels].
PubMed:[Comparative and correlational studies on contents of flavonoids in axial root and lateral root of Scutellaria baicalensis].
PubMed:Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects.
PubMed:Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones.
PubMed:Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells.
PubMed:In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of baicalein.
PubMed:Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal.
PubMed:Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice.
PubMed:Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats.
PubMed:Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes.
PubMed:Enhancement of flavone levels through overexpression of chalcone isomerase in hairy root cultures of Scutellaria baicalensis.
PubMed:Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation.
PubMed:A novel therapeutic regimen for hepatic fibrosis using the combination of mesenchymal stem cells and baicalin.
PubMed:Baicalein and wogonin are activators of rat TREK-2 two-pore domain K+ channel.
PubMed:Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain.
PubMed:Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase.
PubMed:Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration?
PubMed:Analysis of essential oils from different organs of Scutellaria baicalensis.
PubMed:Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture.
PubMed:Flavonoid pharmacokinetics and tissue distribution after repeated dosing of the roots of Scutellaria baicalensis in rats.
PubMed:Wogonin induces differentiation and neurite outgrowth of neural precursor cells.
PubMed:Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha} pathway.
PubMed:Effects of a skullcap root supplement on haematology, serum parameters and antioxidant enzymes in rabbits on a high-cholesterol diet.
PubMed:Evaluation of anti-oxidant capacity of root of Scutellaria baicalensis Georgi, in comparison with roots of Polygonum multiflorum Thunb and Panax ginseng CA Meyer.
PubMed:Opposite expression of securin and γ-H2AX regulates baicalein-induced cancer cell death.
PubMed:Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells.
PubMed:Impacts of recent cultivation on genetic diversity pattern of a medicinal plant, Scutellaria baicalensis (Lamiaceae).
PubMed:Anti-nociceptive mechanism of baicalin involved in intervention of TRPV1 in DRG neurons in vitro.
PubMed:Molecular cloning and expression profiling of a chalcone synthase gene from hairy root cultures of Scutellaria viscidula Bunge.
PubMed:On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi.
PubMed:The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis.
PubMed:Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells.
PubMed:Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages.
PubMed:MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells.
PubMed:Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction.
PubMed:Baicalin administration is effective in positive regulation of twenty-four ischemia/reperfusion-related proteins identified by a proteomic study.
PubMed:In vitro antifungal activity of the aqueous extract of Scutellaria baicalensis Georgi root against Candida albicans.
PubMed:Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: comparison between American ginseng and Scutellaria baicalensis using an ob/ob mice model.
PubMed:Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro.
PubMed:In vitro study of the tocolytic effect of oroxylin A from Scutellaria baicalensis root.
PubMed:[Separation and purification and structural characterization of baicalein].
PubMed:Optimization of capillary liquid chromatography with electrochemical detection for determining femtogram levels of baicalin and baicalein on the basis of the FUMI theory.
PubMed:Wogonin inhibits microglial cell migration via suppression of nuclear factor-kappa B activity.
PubMed:Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats.
PubMed:[Determination of the contents of trace elements in chinese herbal medicines for treating respiratory system diseases].
PubMed:Validation of a HPLC method for flavonoid biomarkers in skullcap (Scutellaria) and its use to illustrate wide variability in the quality of commercial tinctures.
PubMed:Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products.
PubMed:Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression.
PubMed:Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels.
PubMed:The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice.
PubMed:Effect of the flavonoid, oroxylin A, on transient cerebral hypoperfusion-induced memory impairment in mice.
PubMed:Characterization of flavonoids in the traditional Chinese herbal medicine-Huangqin by liquid chromatography coupled with electrospray ionization mass spectrometry.
PubMed:Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells.
PubMed:Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI.
PubMed:Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells.
PubMed:Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity.
PubMed:[Analysis of the volatile components of YL2000 decoction by GC-MS].
PubMed:Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury.
PubMed:[Determination of contents of the effective ingredients in root of Scutellaria baicalensis by HPLC-ECD].
PubMed:Traditional Chinese medicine Bao Gan Ning increase phosphorylation of CREB in liver fibrosis in vivo and in vitro.
PubMed:Skullcapflavone I from Scutellaria baicalensis induces apoptosis in activated rat hepatic stellate cells.
PubMed:Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract.
PubMed:Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells.
PubMed:Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection.
PubMed:Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism.
PubMed:Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study.
PubMed:[Experimental study on anti-pyretic effect of gegen qin lian decoction and its compounds].
PubMed:Neuroprotective effect of wogonin: potential roles of inflammatory cytokines.
PubMed:Wogonin inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion.
PubMed:Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.
PubMed:Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95.
PubMed:Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats.
PubMed:Antimutagenic and antiradical properties of flavones from the roots of Scutellaria baicalensis georgi.
PubMed:[The study of characteristics of absorption and separation of different glycoside on macropore resins].
PubMed:Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis.
PubMed:Involvement of nuclear factor-kappaB in the inhibition of interleukin-12 production from mouse macrophages by baicalein, a flavonoid in Scutellaria baicalensis.
PubMed:Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia.
PubMed:Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties.
PubMed:[A novel approach to quality evaluation of root of Scutellaria baicalensis by DPPH free radical scavenging].
PubMed:Flavonoid baicalein attenuates activation-induced cell death of brain microglia.
PubMed:Baicalin promoted the repair of DNA single strand breakage caused by H2O2 in cultured NIH3T3 fibroblasts.
PubMed:The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study.
PubMed:Baikal skullcap extract stimulates neurite growth in cultures of rat dorsal root Ganglia.
PubMed:Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.
PubMed:Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats.
PubMed:Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice.
PubMed:[A histochemical study on baicalin].
PubMed:Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules.
PubMed:The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production.
PubMed:Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes.
PubMed:Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin.
PubMed:Cloning and expression of UDP-glucose: flavonoid 7-O-glucosyltransferase from hairy root cultures of Scutellaria baicalensis.
PubMed:Baicalein: an in vitro antigenotoxic compound from Scutellaria baicalensis.
PubMed:Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes.
PubMed:Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages.
PubMed:Effects of Sho-saiko-to, San'o-shashin-to and Scutellariae Radix on intracellular Ca2+ mobilization in C6 rat glioma cells.
PubMed:Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca2+ elevation by reducing phospholipase C activity in C6 rat glioma cells.
PubMed:
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