cytochrome C

cosmetic agents

2D:
3D:
CAS Number:	9007-43-6
ECHA EC Number:	232-700-9
FDA UNII:	Search
Category:	cosmetic agents
IUPAC Name:	cytochrome C
InChI :	InChI=1/C42H54N8O6S2.Fe/c1-19-25(9-11-37(51)52)33-16-34-26(10-12-38(53)54)20(2)30(48-34)14-35-40(24(6)58-18-28(44)42(56)46-8)22(4)32(50-35)15-36-39(21(3)31(49-36)13-29(19)47-33)23(5)57-17-27(43)41(55)45-7;/h13-16,23-24,27-28H,9-12,17-18,43-44H2,1-8H3,(H6,45,46,47,48,49,50,51,52,53,54,55,56);/q;+2/p-2/b29-13-,30-14-,31-13-,32-15-,33-16-,34-16-,35-14-,36-15-;
Std.InChI:	InChI=1S/C42H54N8O6S2.Fe/c1-19-25(9-11-37(51)52)33-16-34-26(10-12-38(53)54)20(2)30(48-34)14-35-40(24(6)58-18-28(44)42(56)46-8)22(4)32(50-35)15-36-39(21(3)31(49-36)13-29(19)47-33)23(5)57-17-27(43)41(55)45-7;/h13-16,23-24,27-28H,9-12,17-18,43-44H2,1-8H3,(H6,45,46,47,48,49,50,51,52,53,54,55,56);/q;+2/p-2/b29-13-,30-14-,31-13-,32-15-,33-16-,34-16-,35-14-,36-15-;
InChIKey :	WFVBWSTZNVJEAY-LQYMXSBUBL
Std.InChIKey:	WFVBWSTZNVJEAY-VQGVYVAWSA-L
SMILES :	Cc1/c/2c/c3n/c(c\c4c(c(c([n-]4)/cc/5\nc(/cc(/c1CCC(=O)O)\[n-]2)C(=C5C)CCC(=O)O)C)C(C)SCC(C(=O)NC)N)/C(=C3C(C)SCC(C(=O)NC)N)C.[Fe+2]
MDL:	MFCD00130890

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Flash Point:	32.00 °F. TCC ( 0.00 °C. ) (est)

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	skin conditioning

Suppliers:

BOC Sciences

For experimental / research use only.

Cytochrome C Iron content >0.43% (

George Uhe Company

Cytochrome C

Glentham Life Sciences

Cytochrome C, from equine heart

Pangaea Sciences

Cytochrome C injectable

Sigma-Aldrich: Sigma

For experimental / research use only.

Cytochrome C from bovine heart ≥95% based on Mol. Wt. 12,327 basis

sds

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 > 3000 mg/kg Drugs in Japan Vol. 6, Pg. 461, 1982. intraperitoneal-rat LD50 6250 mg/kg Toksikologicheskii Vestnik. Vol. (4), Pg. 40, 1994. oral-rat LDLo 10000 mg/kg Toksikologicheskii Vestnik. Vol. (4), Pg. 40, 1994.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
cosmetic agents
Recommendation for cytochrome C usage levels up to:
	not for fragrance use.

Recommendation for cytochrome C flavor usage levels up to:
	not for flavor use.

Safety References:

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):9007-43-6

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :439171

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

3-[7,12-bis[1-[2-amino-3-(methylamino)-3-oxopropyl]sulfanylethyl]-18-(2-carboxyethyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoicacid;iron(2+)

Chemidplus:0009007436

RTECS:HA5365000 for cas# 9007-43-6

References:

	3-[7,12-bis[1-[2-amino-3-(methylamino)-3-oxopropyl]sulfanylethyl]-18-(2-carboxyethyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoicacid;iron(2+)
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	439171
Pubchem (sid):	135323767

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
KEGG (GenomeNet):	C00524
HMDB (The Human Metabolome Database):	HMDB12920
FooDB:	FDB029208
Export Tariff Code:	2933.90.9500
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components :

None Found

Potential Uses:

biological additives

Occurrence (nature, food, other):

found in nature

Synonyms:

3-[7,12-bis[1-[2-	amino-3-(methylamino)-3-oxopropyl]sulfanylethyl]-18-(2-carboxyethyl)-3,8,13,17-tetramethylporphyrin-21,23-diid-2-yl]propanoicacid;iron(2+)
	cytorest
	ferricytochrome C
	ferrocytochrome C
	hematin-protein
	horse heart cytochrome C
	horse-cytochrome C
	landrax
	myohematin

Articles:

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PubMed:Oxygen consumption rate of permeabilized cells and isolated mitochondria from pork M. masseter and liver examined fresh and after freeze-thawing at different pH values.

PubMed:Apoptogenic activity of auraptene of Zanthoxylum schinifolium toward human acute leukemia Jurkat T cells is associated with ER stress-mediated caspase-8 activation that stimulates mitochondria-dependent or -independent caspase cascade.

PubMed:Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3.

PubMed:Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.

CONTENTS

EU/US Properties EU/US Suppliers Safety Safety in use Safety reference References Other Blenders Uses Occurrence Synonyms Articles