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nutmeg

spices, other natural seasonings and flavorings
2D:
3D:
CAS Number: 84082-68-8
FDA UNII: Search
Category: spices, other natural seasonings and flavorings
IUPAC Name: nutmeg

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:Search
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Perfumer and Flavorist:Search
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PubMed:Search
NCBI:Search
FDA/DG SANTE Petitions, Reviews, Notices:
182.10 Nutmeg and Mace View - review
FEMA Number:2792 nutmeg
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):977051-44-7 ; NUTMEG (MYRISTICA FRAGRANS HOUTT.)
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart B--Specific Food Labeling Requirements
Sec. 101.22 Foods; labeling of spices, flavorings, colorings and chemical preservatives.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.10 Spices and other natural seasonings and flavorings.

Physical Properties:

Appearance:brown seed (est)
Food Chemicals Codex Listed: No

Organoleptic Properties:

Cosmetic Information:

None found

Safety Information:

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 500 mg/kg
Journal of Neuropsychiatry. Vol. 2, Pg. 205, 1961.

oral-human TDLo 214 mg/kg
BEHAVIORAL: EUPHORIACARDIAC: CHANGE IN RATEBEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Neuropsychiatry. Vol. 2, Pg. 205, 1961.

oral-man TDLo 143 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: CHANGE IN REM SLEEP (HUMAN)
Japanese Journal of Toxicology. Vol. 2, Pg. 169, 1989.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
spices, other natural seasonings and flavorings
Recommendation for nutmeg usage levels up to:
not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: -2000.00000
beverages(nonalcoholic): -700.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -100.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -550.00000
fruit ices: -550.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -670.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety References:

ClinicalTrials.gov:search
Daily Med:search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
myristica fragrans houtt.
Chemidplus:0084082688

References:

myristica fragrans houtt.
Pubchem (sid):135361447

Other Information:

FDA Substances Added to Food (formerly EAFUS):View
FDA Listing of Food Additive Status:View
Wikipedia:View

Potential Blenders and core components :

None Found

Potential Uses:

FRspice

Occurrence (nature, food, other):

nutmeg seed
Search Trop Picture

Synonyms:

myristica fragrans
myristica fragrans moluccas
myristica fragrans venezuela
nutmeg whole or ground, available as 100% certified organic

Articles:

PubMed:Modulation of Colon Cancer by Nutmeg.
PubMed:Ultra high performance liquid chromatography tandem mass spectrometry method for the simultaneous determination of multiple bioactive constituents in fruit extracts of Myristica fragrans and its marketed multi-herbal formulations using a polarity switching technique.
PubMed:Effect of some essential oils on phagocytosis and complement system activity.
PubMed:Assessing intake of spices by pattern of spice use, frequency of consumption and portion size of spices consumed from routinely prepared dishes in southern India.
PubMed:Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.
PubMed:Antimutagenic effects of aqueous fraction of Myristica fragrans (Houtt.) leaves on Salmonella typhimurium and Mus musculus.
PubMed:New neolignans from the seeds of Myristica fragrans that inhibit nitric oxide production.
PubMed:Screening and study of antifungal activity of leaf litter actinomycetes isolated from Ternate Island, Indonesia.
PubMed:Structure-plant phytotoxic activity relationship of 7,7'-epoxylignanes, (+)- and (-)-verrucosin: simplification on the aromatic ring substituents.
PubMed:Chemical constituents and activities of the essential oil from Myristica fragrans against cigarette beetle Lasioderma serricorne.
PubMed:Antifungal compounds from turmeric and nutmeg with activity against plant pathogens.
PubMed:'Just a pinch of salt'. An experimental comparison of the effect of repeated exposure and flavor-flavor learning with salt or spice on vegetable acceptance in toddlers.
PubMed:Chemical constituents from Myristica fragrans fruit.
PubMed:[Serious powdered nutmeg intoxication].
PubMed:Catalytically and biologically active silver nanoparticles synthesized using essential oil.
PubMed:Myristicin and phenytoin toxicity in an infant.
PubMed:Potent acetylcholinesterase inhibitory compounds from Myristica fragrans.
PubMed:Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
PubMed:The fetal MR appearance of 'nutmeg lung': findings in 8 cases linked to pulmonary lymphangiectasia.
PubMed:Benign Hepatic Mesenchymal Hamartoma (HMH) - A Case Report.
PubMed:Aflatoxins in various food from Istanbul, Turkey.
PubMed:Plant extracts and plant-derived compounds: promising players in a countermeasure strategy against radiological exposure.
PubMed:Allergy to illicit drugs and narcotics.
PubMed:Binary Combination of Carica papaya, Areca catechu and Myristica fragrans with Piperonyl Butoxide / MGK-264 against Freshwater Snail Lymnaea acuminata.
PubMed:[Acute intoxication with nutmeg used as a recreational purpose--a case report].
PubMed:Protective effect of nutmeg aqueous extract against experimentally-induced hepatotoxicity and oxidative stress in rats.
PubMed:In Vitro Antibacterial Activity of Several Plant Extracts and Oils against Some Gram-Negative Bacteria.
PubMed:Nutmeg poisonings: a retrospective review of 10 years experience from the Illinois Poison Center, 2001-2011.
PubMed:Insecticidal and oviposition deterrent properties of some spices against coleopteran beetle, Sitophilus oryzae.
PubMed:A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine.
PubMed:Tree size and its relationship with flowering phenology and reproductive output in Wild Nutmeg trees.
PubMed:Analysis of 2-alkylcyclobutanones in cashew nut, nutmeg, apricot kernel, and pine nut samples: re-evaluating the uniqueness of 2-alkylcyclobutanones for irradiated food identification.
PubMed:Scientific evaluation of edible fruits and spices used for the treatment of peptic ulcer in traditional Iranian medicine.
PubMed:Myristica fragrans seed extract protects against dextran sulfate sodium-induced colitis in mice.
PubMed:New inhibitors of nitric oxide production from the seeds of Myristica fragrans.
PubMed:Impact of cooking and digestion, in vitro, on the antioxidant capacity and anti-inflammatory activity of cinnamon, clove and nutmeg.
PubMed:Pediculicidal effect of herbal shampoo against Pediculus humanus capitis in vitro.
PubMed:Evaluation of analgesic activity and toxicity of alkaloids in Myristica fragrans seeds in mice.
PubMed:[Characterization and nutritional value of a food artisan: the meat pie of Murcia].
PubMed:Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.
PubMed:Quantitation of tr-cinnamaldehyde, safrole and myristicin in cola-flavoured soft drinks to improve the assessment of their dietary exposure.
PubMed:In vitro evaluation of five different herbal extracts as an antimicrobial endodontic irrigant using real time quantitative polymerase chain reaction.
PubMed:Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma.
PubMed:Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria.
PubMed:Knowledge of Eastern materia medica (Indian and Chinese) in pre-modern Mediterranean medical traditions: a study in comparative historical ethnopharmacology.
PubMed:Lipid bilayer membrane affinity rationalizes inhibition of lipid peroxidation by a natural lignan antioxidant.
PubMed:Simultaneous multi-mycotoxin determination in nutmeg by ultrasound-assisted solid-liquid extraction and immunoaffinity column clean-up coupled with liquid chromatography and on-line post-column photochemical derivatization-fluorescence detection.
PubMed:Eugenol alters the integrity of cell membrane and acts against the nosocomial pathogen Proteus mirabilis.
PubMed:Simple and rapid determination of myristicin in human serum.
PubMed:Multiple biological properties of macelignan and its pharmacological implications.
PubMed:Large scale screening of commonly used Iranian traditional medicinal plants against urease activity.
PubMed:Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine.
PubMed:Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans.
PubMed:[Impact of internet on poisoning with psychoactive substances in young people].
PubMed:LEARNING TO CHOOSE AMONG SOCIAL FORAGING STRATEGIES IN ADULT HOUSE SPARROWS (Passer domesticus).
PubMed:Aflatoxins B and g contamination and aflatoxigenic fungi in nutmeg.
PubMed:In vitro antibacterial effects of five volatile oil extracts against intramacrophage Brucella abortus 544.
PubMed:Nutmeg extracts for painful diabetic neuropathy: a randomized, double-blind, controlled study.
PubMed:In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.
PubMed:Cerebral nuclei distribution study of dehydrodiisoeugenol as an anxiogenic agent determined by RP-HPLC.
PubMed:Antibacterial Activity of Myristica fragrans against Oral Pathogens.
PubMed:Effects of macelignan isolated from Myristica fragrans (Nutmeg) on expression of matrix metalloproteinase-1 and type I procollagen in UVB-irradiated human skin fibroblasts.
PubMed:Protective effect of nectandrin B, a potent AMPK activator on neointima formation: inhibition of Pin1 expression through AMPK activation.
PubMed:Malabaricone C suppresses lipopolysaccharide-induced inflammatory responses via inhibiting ROS-mediated Akt/IKK/NF-κB signaling in murine macrophages.
PubMed:Extraction of betulin, trimyristin, eugenol and carnosic acid using water-organic solvent mixtures.
PubMed:Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.
PubMed:Formulas used by Tibetan doctors at Men-Tsee-Khang in India for the treatment of neuropsychiatric disorders and their correlation with pharmacological data.
PubMed:Antiproliferative and molecular mechanism of eugenol-induced apoptosis in cancer cells.
PubMed:Antibacterial activity of crude extracts of prasaprohyai formula and its components against pathogenic bacteria.
PubMed:Fragrant volatile oil composition of Nutmeg Geranium (Pelargonium × fragrans Willd.) from India.
PubMed:Interesting asian plants: their compounds and effects on electrophysiology and behaviour.
PubMed:Estimation of trace elements in mace (Myristica fragrans Houtt) and their effect on uterine cervix cancer induced by methylcholanthrene.
PubMed:Determination of myristicin in commonly spices applying SPE/GC.
PubMed:Malabaricone C inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through induction of heme oxygenase-1.
PubMed:Total and soluble oxalate content of some Indian spices.
PubMed:How to address the physical needs of clients in a mental health setting.
PubMed:Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats.
PubMed:Nutmeg liver and ascites resulting from a membranous web obstruction at the hepatic origin of the inferior vena cava.
PubMed:Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia.
PubMed:Extraction and separation of volatile and fixed oils from seeds of Myristica fragrans by supercritical CO₂: chemical composition and cytotoxic activity on Caco-2 cancer cells.
PubMed:Myrislignan attenuates lipopolysaccharide-induced inflammation reaction in murine macrophage cells through inhibition of NF-κB signalling pathway activation.
PubMed:Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia.
PubMed:The not-so-nice spice: a teenage girl with palpitations and dry mouth.
PubMed:Mutagenic and antimutagenic assessment of methanol leaf extract of Myristica fragrans (Houtt.) using in vitro and in vivo genetic assays.
PubMed:Antioxidants in aqueous extract of Myristica fragrans (Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L. cells.
PubMed:Food components with anticaries activity.
PubMed:Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid.
PubMed:Inhibitory effect on NO production of phenolic compounds from Myristica fragrans.
PubMed:meso-Dihydroguaiaretic acid inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.
PubMed:Nectandrin B activates endothelial nitric-oxide synthase phosphorylation in endothelial cells: role of the AMP-activated protein kinase/estrogen receptor α/phosphatidylinositol 3-kinase/Akt pathway.
PubMed:Analysis of anti-inflammatory dehydrodiisoeugenol and metabolites excreted in rat feces and urine using HPLC-UV.
PubMed:A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
PubMed:Screening of selected Asian spices for anti obesity-related bioactivities.
PubMed:Nutmeg liver.
PubMed:Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways.
PubMed:Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat.
PubMed:Effects of licarin E on expression of matrix metalloproteinase-1 and type-1 procollagen in UVB-irradiated human skin fibroblasts.
PubMed:Metabolism of the lignan dehydrodiisoeugenol in rats.
PubMed:Macelignan inhibits melanosome transfer mediated by protease-activated receptor-2 in keratinocytes.
PubMed:Mycotoxins in foods in Lower Saxony (Germany): results of official control analyses performed in 2009.
PubMed:Determination of ochratoxin A in food: comparison of a stable isotope dilution assay, liquid chromatography-fluorescence detection and an enzyme-linked immunosorbent assay.
PubMed:The spice of life: an analysis of nutmeg exposures in California.
PubMed:Standardization of the Unani drug - Myristica fragrans Houtt. (Javetri) - with modern analytical techniques.
PubMed:Molecular phylogeny of the nutmeg shells (Neogastropoda, Cancellariidae).
PubMed:Insulin secretagogue, alpha-glucosidase and antioxidant activity of some selected spices in streptozotocin-induced diabetic rats.
PubMed:MEG/EEG source reconstruction, statistical evaluation, and visualization with NUTMEG.
PubMed:Toxicology and carcinogenesis studies of isoeugenol (CAS No. 97-54-1) in F344/N rats and B6C3F1 mice (gavage studies).
PubMed:Exploring the costs and benefits of social information use: an appraisal of current experimental evidence.
PubMed:Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice.
PubMed:Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity.
PubMed:Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the Nervous Tissue of Snail Lymnaea acuminata.
PubMed:PPARα activation by culinary herbs and spices.
PubMed:Individual differences in plasticity and sampling when playing behavioural games.
PubMed:[Unusual use of nutmeg].
PubMed:Acaricidal activity of eugenol based compounds against scabies mites.
PubMed:Septicemic salmonellosis in a two-humped camel calf (Camelus bactrianus).
PubMed:AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect.
PubMed:[The elixir of doctor Garrus. Drug or liquor? Original formula or imitation?].
PubMed:Contact dermatitis to Vicks VapoRub.
PubMed:Possible fungistatic implications of betulin presence in betulaceae plants and their hymenochaetaceae parasitic fungi.
PubMed:Antioxidant activity of spice extracts in a liposome system and in cooked pork patties and the possible mode of action.
PubMed:The intestinal permeability of neolignans from the seeds of Myristica fragrans in the Caco-2 cell monolayer model.
PubMed:Histological effects of oral administration of nutmeg on the kidneys of adult Wister rats.
PubMed:Histological effects of long term consumption of nutmeg on the medial geniculate body of adult Wistar rats.
PubMed:[Antioxidant properties of essential oils].
PubMed:Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells.
PubMed:Towards a better understanding of the psychopharmacology of nutmeg: Activities in the mouse tetrad assay.
PubMed:Macelignan attenuates activations of mitogen-activated protein kinases and nuclear factor kappa B induced by lipopolysaccharide in microglial cells.
PubMed:[Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice].
PubMed:Nutmeg (Myristica fragrans Houtt.).
PubMed:Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans.
PubMed:The science of salsa: antimicrobial properties of salsa components to learn scientific methodology.
PubMed:Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation.
PubMed:[Nutmeg poisoning].
PubMed:Anticonvulsant activities of nutmeg oil of Myristica fragrans.
PubMed:Natural existence of 2-alkylcyclobutanones.
PubMed:Neuroprotection and enhanced neurogenesis by extract from the tropical plant Knema laurina after inflammatory damage in living brain tissue.
PubMed:Images in pathology. Nutmeg liver.
PubMed:Historical perspective on the usage of perfumes and scented Articles in ancient Indian literatures.
PubMed:Efficacy of plant essential oils against foodborne pathogens and spoilage bacteria associated with ready-to-eat vegetables: antimicrobial and sensory screening.
PubMed:Larvicidal and adulticidal activities of some medicinal plants against the malarial vector, Anopheles stephensi (Liston).
PubMed:Determination of dehydrodiisoeugenol in rat tissues using HPLC method.
PubMed:Patent ductus arteriosus in Murrah buffalos.
PubMed:[New neolignan from seed of Myristica fragrans].
PubMed:Simultaneous determination of diastereomers (+)-licarin A and isolicarin A from Myristica fragrans in rat plasma by HPLC and its application to their pharmacokinetics.
PubMed:Inhibitory Effects of 150 Plant Extracts on Elastase Activity, and Their Anti-inflammatory Effects.
PubMed:Biological screening of 100 plant extracts for cosmetic use (I): inhibitory activities of tyrosinase and DOPA auto-oxidation.
PubMed:Inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanin biosynthesis.
PubMed:Testing candidate plant barcode regions in the Myristicaceae.
PubMed:Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes.
PubMed:Toxicity of plant essential oils and their components against Lycoriella ingenua (Diptera: Sciaridae).
PubMed:Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae).
PubMed:Protective Effects of macelignan on cisplatin-induced hepatotoxicity is associated with JNK activation.
PubMed:[Acute nutmeg intoxication in Spain].
PubMed:Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation.
PubMed:[Chemical constituents of Myristica fragrans Houttuyn seed and their physiological activities].
PubMed:Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes.
PubMed:Protective capacities of certain spices against peroxynitrite-mediated biomolecular damage.
PubMed:Effects of essential oils of oregano and nutmeg on growth and survival of Yersinia enterocolitica and Listeria monocytogenes in barbecued chicken.
PubMed:[GC-MS analysis of essential oil from nutmeg processed by different traditional methods].
PubMed:Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds.
PubMed:Biotransformation of myrislign
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