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verbena absolute france

flavor and fragrance agents
2D:
3D:
CAS Number: 8024-12-2
FDA UNII: Search
Category: flavor and fragrance agents
IUPAC Name: verbena absolute france

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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FDA Mainterm (SATF):8024-12-2 ; LEMON VERBENA, OIL (LIPPIA CITRIODORA)
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.510 Natural flavoring substances and natural substances used in conjunction with flavors.

Physical Properties:

Food Chemicals Codex Listed: No
Soluble in:
alcohol
water, 84.71 mg/L @ 25 °C (est)
Insoluble in:
water

Cosmetic Information:

None found

Safety Information:

European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
R 43 - May cause sensitisation by skin contact.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 137S, 1992.

Dermal Toxicity:
skin-rabbit LD50 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 137S, 1992.

skin-guinea pig LD50 > 5000 mg/kg
Food and Chemical Toxicology. Vol. 30, Pg. 137S, 1992.

Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect:
Dermal sensitization, Phototoxicity
IFRA fragrance material specification:
Verbena absolute obtained from Lippia citriodora Kunth, should not be used as afragrance ingredient at a level over 1% in fragrance compounds.This recommendation is based on test results of RIFM showing sensitization reactionat 12% and no sensitization reaction at 2%. There is no evidence of photoxicity at100% on hairless mice (private communication to IFRA).
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
citral Max. Found: 25.6 % and Reason: Sensitization
citronellol Max. Found: 0.45 % and Reason: Sensitization
eugenol Max. Found: 0.55 % and Reason: Sensitization
geraniol Max. Found: 4.1 % and Reason: Sensitization
methyl eugenol Max. Found: 0.1 % and Reason: Sensitization
trans-asarone Max. Found: 0.1 % and Reason: Carcinogenicity
cis-asarone Max. Found: 0.01 % and Reason: Carcinogenicity
alpha-cedrene Max. Found: 0.5 % and Reason: Sensitization
beta-cedrene Max. Found: 0.1 % and Reason: Sensitization
View the IFRA Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.12 %
Category 2: Products applied to the axillae
0.037 %
Category 3: Products applied to the face/body using fingertips
0.74 %
Category 4: Products related to fine fragrance
0.69 %
Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.17 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.17 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.17 %
Category 5D: Baby Creams, baby Oils and baby talc
0.17 %
Category 6: Products with oral and lip exposure
0.40 %
Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
1.40 %
Category 7B: Leave-on products applied to the hair with some hand contact
1.40 %
Category 8: Products with significant anogenital exposure
0.072 %
Category 9: Products with body and hand exposure, primarily rinse off
1.30 %
Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
4.80 %
Category 10B: Household aerosol/spray products
4.80 %
Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
2.70 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
2.70 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
No Restriction
Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

Recommendation for verbena absolute france flavor usage levels up to:
30.0000 ppm in the finished product.

Safety References:

EPI System: View
EPA Substance Registry Services (TSCA):8024-12-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:2
lippia citriodora absolute
Chemidplus:008024122
aloysia citriodora extract
Chemidplus:085116638

References:

lippia citriodora absolute
Canada Domestic Sub. List:8024-12-2
Pubchem (sid):3730676
aloysia citriodora extract
Canada Domestic Sub. List:85116-63-8
Pubchem (sid):3777682

Other Information:

Export Tariff Code:3301.90.5000
Wikipedia:View

Potential Blenders and core components :

For Odor
No odor group found for these
verbena absolute spain
FL/FR
balsamic
balsamic
iso
bornyl acetate
FL/FR
iso
bornyl phenyl acetate
FL/FR
fenchyl acetate
FL/FR
chocolate
iso
butyl phenyl acetate
FL/FR
citrus
abronia fragrance
FR
beta-
bisabolol
FL/FR
citral diethyl acetal
FL/FR
citral dimethyl acetal
FL/FR
2-
heptanol
FL/FR
lemongrass oil
FL/FR
lime oil expressed florida
FL/FR
alpha-
methylene citronellal
FR
ocimum americanum leaf oil
FR
verbena fragrance
FR
verbena oil replacer
FR
verbena oil spain
FL/FR
verbena oil terpeneless
FL/FR
verbena specialty
FR
coconut
coconut lime verbena fragrance
FR
earthy
(Z)-4-
octen-1-ol
FL/FR
floral
citronellal
FL/FR
citronellyl benzoate
FL/FR
freesia acetate
FR
lavender oil
FL/FR
para-
methyl benzyl acetate
FL/FR
methyl benzyl acetate (mixed ortho-,meta-,para-)
FL/FR
petitgrain lemon oil
FL/FR
phenyl amyl alcohol
FL/FR
rhodinyl propionate
FL/FR
rose undecene
FR
fruity
cinnamyl isobutyrate
FL/FR
(E)-2-
nonen-1-yl acetate
FL/FR
fungal
hydroxymethyl hexyl ethyl ketone
FL/FR
green
heptyl acetate
FL/FR
magnolia flower oil
FL/FR
yerba mate leaf oil
FL/FR
hay
woodruff absolute
FR
herbal
arnica flower oil
FR
clary sage absolute
FL/FR
coriander oleoresin
FL/FR
lavender concrete
FL/FR
matricaria chamomilla flower oil
FL/FR
curled
parsley seed oil
FL/FR
laevo-
perillaldehyde
FL/FR
perillaldehyde
FL/FR
tea leaf absolute
FL/FR
alpha-
terpinyl acetate
FL/FR
tilia cordata flower
CS
tilia cordata flower extract
FL/FR
honey
methyl phenyl acetate
FL/FR
leathery
black
tea leaf absolute
FL/FR
minty
dextro-
dihydrocarvone
FL/FR
spicy
caraway seed oleoresin
FL/FR
4-
carvomenthenol
FL/FR
gingergrass oil
FR
hollyberry fragrance
FR
tea
camellia oleifera leaf extract
FL/FR
terpenic
para-
cymene
FL/FR
frankincense oil
FL/FR
tobacco
2,6,6-
trimethyl-2-hydroxycyclohexanone
FL/FR
tonka
deertongue oleoresin
FR
flouve absolute
FR
woody
(E)-beta-
farnesene
FL/FR
alpha-
terpinene
FL/FR
For Flavor
No flavor group found for these
iso
bornyl phenyl acetate
FL/FR
capsicum oleoresin CO2 extract
FL
citronellyl benzoate
FL/FR
(E)-beta-
farnesene
FL/FR
hydroxymethyl hexyl ethyl ketone
FL/FR
magnolia flower oil
FL/FR
methyl benzyl acetate (mixed ortho-,meta-,para-)
FL/FR
(Z)-4-
octen-1-ol
FL/FR
phenyl amyl alcohol
FL/FR
2,6,6-
trimethyl-2-hydroxycyclohexanone
FL/FR
verbena absolute spain
FL/FR
yerba mate leaf oil
FL/FR
acidic
acidic
(E)-2-
hexenoic acid
FL
aromatic
laevo-
perillaldehyde
FL/FR
balsamic
styrax gum (liquidambar styraciflua)
FL
citrus
beta-
bisabolol
FL/FR
citral diethyl acetal
FL/FR
citral dimethyl acetal
FL/FR
lemon verbena distillates
FL
lemongrass oil
FL/FR
lime oil expressed florida
FL/FR
petitgrain lemon oil
FL/FR
verbena oil france
FL
verbena oil morocco
FL
verbena oil spain
FL/FR
verbena oil terpeneless
FL/FR
cocoa
iso
butyl phenyl acetate
FL/FR
cooling
4-
carvomenthenol
FL/FR
floral
citronellal
FL/FR
methyl phenyl acetate
FL/FR
fruity
cinnamyl isobutyrate
FL/FR
2-
heptanol
FL/FR
para-
methyl benzyl acetate
FL/FR
rhodinyl propionate
FL/FR
green
dextro-
dihydrocarvone
FL/FR
heptyl acetate
FL/FR
herbal
clary sage absolute
FL/FR
coriander oleoresin
FL/FR
lavender concrete
FL/FR
lavender oil
FL/FR
matricaria chamomilla flower oil
FL/FR
curled
parsley seed oil
FL/FR
tilia cordata flower extract
FL/FR
spicy
caraway seed oleoresin
FL/FR
perillaldehyde
FL/FR
tea
camellia oleifera leaf extract
FL/FR
black
tea leaf absolute
FL/FR
tea leaf absolute
FL/FR
terpenic
para-
cymene
FL/FR
alpha-
terpinene
FL/FR
tropical
coconut lime verbena flavor
FL
waxy
(E)-2-
nonen-1-yl acetate
FL/FR
woody
iso
bornyl acetate
FL/FR
fenchyl acetate
FL/FR
frankincense oil
FL/FR
alpha-
terpinyl acetate
FL/FR

Potential Uses:

Occurrence (nature, food, other):

lippia citriodora
Search Trop Picture

Synonyms:

aloysia triphylla absolute france
lippia citriodora absolute france

Articles:

PubMed:Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments.
PubMed:Phenylpropanoids and their metabolites are the major compounds responsible for blood-cell protection against oxidative stress after administration of Lippia citriodora in rats.
PubMed:Comparative study on in vitro activities of citral, limonene and essential oils from Lippia citriodora and L. alba on yellow fever virus.
PubMed:Chromatographic and mass spectrometric characterization of essential oils and extracts from Lippia (Verbenaceae) aromatic plants.
PubMed:Evaluation of different extraction approaches for the determination of phenolic compounds and their metabolites in plasma by nanoLC-ESI-TOF-MS.
PubMed:Antimicrobial activity of food-compatible plant extracts and chitosan against naturally occurring micro-organisms in tomato juice.
PubMed:A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management.
PubMed:Antihyperalgesic activity of verbascoside in two models of neuropathic pain.
PubMed:Phytoestrogens enhance antioxidant enzymes after swimming exercise and modulate sex hormone plasma levels in female swimmers.
PubMed:Antioxidant effect of lemon verbena extracts in lymphocytes of university students performing aerobic training program.
PubMed:Characterization of phenolic and other polar compounds in a lemon verbena extract by capillary electrophoresis-electrospray ionization-mass spectrometry.
PubMed:Preparation and physicochemical characterization of Ag nanoparticles biosynthesized by Lippia citriodora (Lemon Verbena).
PubMed:Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro.
PubMed:Antimicrobial, antioxidant and cytotoxic activities and phytochemical screening of some yemeni medicinal plants.
PubMed:Authenticity control of essential oils containing citronellal and citral by chiral and stable-isotope gas-chromatographic analysis.
PubMed:Antimicrobial activity of essential oils against Helicobacter pylori.
PubMed:Studies on the antioxidant activity of Lippia citriodora infusion: scavenging effect on superoxide radical, hydroxyl radical and hypochlorous acid.
PubMed:Flavonoids from Lippia citriodora.
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