| PubMed:Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review. |
| PubMed:Application of response surface methodology to optimise supercritical carbon dioxide extraction of volatile compounds from Crocus sativus. |
| PubMed:The Synergic Effects of Crocus Sativus L. and Low Frequency Electromagnetic Field on VEGFR2 Gene Expression in Human Breast Cancer Cells. |
| PubMed:Nephrotoxicity and hepatotoxicity evaluation of Crocus sativus stigmas in neonates of nursing mice. |
| PubMed:A comparative study of saffron aqueous extract and its active ingredient, crocin on the in vitro maturation, in vitro fertilization, and in vitro culture of mouse oocytes. |
| PubMed:Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. |
| PubMed:Saffron improves epididymal sperm parameters in rats exposed to cadmium. |
| PubMed:Hepatoprotective herbs, avicenna viewpoint. |
| PubMed:Evaluation of lung and bronchoalveolar lavage fluid oxidative stress indices for assessing the preventing effects of safranal on respiratory distress in diabetic rats. |
| PubMed:Proposed cytotoxic mechanisms of the saffron carotenoids crocin and crocetin on cancer cell lines. |
| PubMed:Study on diuretic activity of saffron (stigma of Crocus sativus L.) Aqueous extract in rat. |
| PubMed:Antidepressant Effect of Crocus sativus Aqueous Extract and its Effect on CREB, BDNF, and VGF Transcript and Protein Levels in Rat Hippocampus. |
| PubMed:Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-A(y) mice. |
| PubMed:A review of the chemistry and uses of crocins and crocetin, the carotenoid natural dyes in saffron, with particular emphasis on applications as colorants including their use as biological stains. |
| PubMed:FTIR spectroscopic evaluation of changes in the cellular biochemical composition of the phytopathogenic fungus Alternaria alternata induced by extracts of some Greek medicinal and aromatic plants. |
| PubMed:Flavonoid Determination in the Quality Control of Floral Bioresidues from Crocus sativus L. |
| PubMed:The Effect of Chronic Administration of Saffron (Crocus sativus) Stigma Aqueous Extract on Systolic Blood Pressure in Rats. |
| PubMed:Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypertensive rats. |
| PubMed:Can Saffron (Crocus sativus) be effective in the treatment of leishmaniasis? |
| PubMed:Crocetin, a Carotenoid from Gardenia jasminoides Ellis, Protects against Hypertension and Cerebral Thrombogenesis in Stroke-prone Spontaneously Hypertensive Rats. |
| PubMed:Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. |
| PubMed:An improvement in sexual function is related to better quality of life, regardless of urinary function improvement: results from the IDIProst® Gold Study. |
| PubMed:In-chain neutral hydrocarbon loss from crocin apocarotenoid ester glycosides and the crocetin aglycon (Crocus sativus L.) by ESI-MS(n) (n=2, 3). |
| PubMed:Effective isolation protocol for secondary metabolites from saffron: semi-preparative scale preparation of crocin-1 and trans-crocetin. |
| PubMed:Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. |
| PubMed:A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients. |
| PubMed:Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. |
| PubMed:Effect of split foliar fertilisation on the quality and quantity of active constituents in saffron (Crocus sativus L.). |
| PubMed:Bioactivity assessment and toxicity of crocin: a comprehensive review. |
| PubMed:Saffron and natural carotenoids: Biochemical activities and anti-tumor effects. |
| PubMed:Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. |
| PubMed:Determination of Metal Content in Crocus sativus L. Corms in Dormancy and Waking Stages. |
| PubMed:Cytotoxic effect against 3T3 fibroblasts cells of saffron floral bio-residues extracts. |
| PubMed:The Extract of Crocus sativus and Its Constituent Safranal, Affect Serum Levels of Endothelin and Total Protein in Sensitized Guinea Pigs. |
| PubMed:Evaluation of teratogenic effects of crocin and safranal, active ingredients of saffron, in mice. |
| PubMed:Crocins, the active constituents of Crocus Sativus L., counteracted ketamine-induced behavioural deficits in rats. |
| PubMed:Relative expression of CsZCD gene and apocarotenoid biosynthesis during stigma development in Crocus sativus L. |
| PubMed:DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. |
| PubMed:Crocins with high levels of sugar conjugation contribute to the yellow colours of early-spring flowering crocus tepals. |
| PubMed:Protective effect of saffron extract against doxorubicin cardiotoxicity in isolated rabbit heart. |
| PubMed:Cytotoxic effects of crocin on MOLT-4 human leukemia cells. |
| PubMed:An overview on saffron, phytochemicals, and medicinal properties. |
| PubMed:Saffron (Crocus sativus L.) powder as an ingredient of rye bread: an anti-diabetic evaluation. |
| PubMed:Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer. |
| PubMed:A systematic review of anti-obesity medicinal plants - an update. |
| PubMed:Plant growth promoting bacteria from Crocus sativus rhizosphere. |
| PubMed:Saffron administration prevents selenite-induced cataractogenesis. |
| PubMed:Effect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteers. |
| PubMed:The effect of the crocus sativus L. Carotenoid, crocin, on the polymerization of microtubules, in vitro. |
| PubMed:Protective Effect of Safranal, a Constituent of Crocus sativus, on Quinolinic Acid-induced Oxidative Damage in Rat Hippocampus. |
| PubMed:Crocin restores hypotensive effect of subchronic administration of diazinon in rats. |
| PubMed:Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats. |
| PubMed:Development and Validation of HPLC Method for Determination of Crocetin, a constituent of Saffron, in Human Serum Samples. |
| PubMed:Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers. |
| PubMed:Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat. |
| PubMed:Safranal: from an aromatic natural product to a rewarding pharmacological agent. |
| PubMed:A survey on saffron in major islamic traditional medicine books. |
| PubMed:Protective effects of saffron (Crocus sativus) against lethal ventricular arrhythmias induced by heart reperfusion in rat: a potential anti-arrhythmic agent. |
| PubMed:Role of saffron and its constituents on cancer chemoprevention. |
| PubMed:Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma. |
| PubMed:Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. |
| PubMed:Affinity-based target deconvolution of safranal. |
| PubMed:The effect of the extract of Crocus sativus on tracheal responsiveness and plasma levels of IL-4, IFN-γ, total NO and nitrite in ovalbumin sensitized guinea-pigs. |
| PubMed:Assessment of cytotoxic properties of safranal and nanoliposomal safranal in various cancer cell lines. |
| PubMed:Adverse effects of herbal medicines: an overview of systematic reviews. |
| PubMed:Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. |
| PubMed:Plant-based medicines for anxiety disorders, Part 1: a review of preclinical studies. |
| PubMed:Alleviation of viper venom induced platelet apoptosis by crocin (Crocus sativus): implications for thrombocytopenia in viper bites. |
| PubMed:Multitarget drugs of plants origin acting on Alzheimer's disease. |
| PubMed:Crocetin administration ameliorates endotoxin-induced disseminated intravascular coagulation in rabbits. |
| PubMed:Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. |
| PubMed:The potential effect of the extract of Crocus sativus and safranal on the total and differential white blood cells of ovalbumin-sensitized guinea pigs. |
| PubMed:Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway. |
| PubMed:Protective effect of crocin against cerebral ischemia in a dose-dependent manner in a rat model of ischemic stroke. |
| PubMed:New minor glycoside components from saffron. |
| PubMed:Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment. |
| PubMed:Revisiting extraction of bioactive apocarotenoids from Crocus sativus L. dry stigmas (saffron). |
| PubMed:Effect of Aqueous Extract of Crocus sativus L. on Morphine-Induced Memory Impairment. |
| PubMed:Increasing the applications of Crocus sativus flowers as natural antioxidants. |
| PubMed:Quality control of saffron (Crocus sativus L.): development of SCAR markers for the detection of plant adulterants used as bulking agents. |
| PubMed:Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive-compulsive disorder. |
| PubMed:Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms. |
| PubMed:A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status. |
| PubMed:Isolation and characterization of a first set of polymorphic microsatellite markers in saffron, Crocus sativus (Iridaceae). |
| PubMed:Anti-inflammatory properties of drugs from saffron crocus. |
| PubMed:Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model. |
| PubMed:Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation. |
| PubMed:Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats. |
| PubMed:Vipera russelli venom-induced oxidative stress and hematological alterations: amelioration by crocin a dietary colorant. |
| PubMed:In vitro cormlet production of saffron (Crocus sativus L. Kashmirianus) and their flowering response under greenhouse. |
| PubMed:Chemical, microbiological, textural, color, and sensory characteristics of pressed ewe milk cheeses with saffron (Crocus sativus L.) during ripening. |
| PubMed:Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review. |
| PubMed:Radical scavenging activity and LC-MS metabolic profiling of petals, stamens, and flowers of Crocus sativus L. |
| PubMed:Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats. |
| PubMed:The effect of the extract of Crocus sativus and its constituent safranal, on lung pathology and lung inflammation of ovalbumin sensitized guinea-pigs. |
| PubMed:Characterization of a glucosyltransferase enzyme involved in the formation of kaempferol and quercetin sophorosides in Crocus sativus. |
| PubMed:Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. |
| PubMed:Isolation of a CENTRORADIALIS/TERMINAL FLOWER1 homolog in saffron (Crocus sativus L.): characterization and expression analysis. |
| PubMed:Saffron (Crocus sativus) ethanolic extract and its constituent, safranal, inhibits morphine-induced place preference in mice. |
| PubMed:Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. |
| PubMed:Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation. |
| PubMed:Quantification of main bioactive metabolites from saffron (Crocus sativus) stigmas by a micellar electrokinetic chromatographic (MEKC) method. |
| PubMed:Recovery of crocins from saffron stigmas (Crocus sativus) in aqueous two-phase systems. |
| PubMed:An evidence-based systematic review of saffron (Crocus sativus) by the Natural Standard Research Collaboration. |
| PubMed:Ethnobotanical treatment strategies against Alzheimer's disease. |
| PubMed:Comparison of different tandem mass spectrometric techniques (ESI-IT, ESI- and IP-MALDI-QRTOF and vMALDI-TOF/RTOF) for the analysis of crocins and picrocrocin from the stigmas of Crocus sativus L. |
| PubMed:HPLC/PDA/ESI-MS evaluation of saffron (Crocus sativus L.) adulteration. |
| PubMed:Identification and possible role of a MYB transcription factor from saffron (Crocus sativus). |
| PubMed:Identification of differentially accumulated proteins associated with embryogenic and non-embryogenic calli in saffron (Crocus sativus L.). |
| PubMed:Effects of Saffron (Crocus sativus L.) Aqueous Extract on In vitro Maturation, Fertilization and Embryo Development of Mouse Oocytes. |
| PubMed:The effect of Crocus sativus extract on human lymphocytes' cytokines and T helper 2/T helper 1 balance. |
| PubMed:Saponins from the Spanish saffron Crocus sativus are efficient adjuvants for protein-based vaccines. |
| PubMed:Frequency-dependent electrophysiological remodeling of the AV node by hydroalcohol extract of Crocus sativus L. (saffron) during experimental atrial fibrillation: the role of endogenous nitric oxide. |
| PubMed:Developmental and stress regulation of gene expression for a 9-cis-epoxycarotenoid dioxygenase, CstNCED, isolated from Crocus sativus stigmas. |
| PubMed:Crocin promotes non-rapid eye movement sleep in mice. |
| PubMed:Akt/GSK-3β/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia-reperfusion injury in rats. |
| PubMed:Improvement of cytotoxic and apoptogenic properties of crocin in cancer cell lines by its nanoliposomal form. |
| PubMed:Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. |
| PubMed:Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. |
| PubMed:Chemical constituents and bioactivities of the liposoluble fraction from different medicinal parts of Crocus sativus. |
| PubMed:The role of phytochemicals in the treatment and prevention of dementia. |
| PubMed:The study of the E-class SEPALLATA3-like MADS-box genes in wild-type and mutant flowers of cultivated saffron crocus (Crocus sativus L.) and its putative progenitors. |
| PubMed:Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. |
| PubMed:Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. |
| PubMed:Conception in unilateral right tubal blockage with herbomineral formulations: a case report. |
| PubMed:Identification of a quinazoline alkaloid produced by Penicillium vinaceum, an endophytic fungus from Crocus sativus. |
| PubMed:Saffron (Crocus sativus) aqueous extract and its constituent crocin reduces stress-induced anorexia in mice. |
| PubMed:Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. |
| PubMed:Determination of some phenolic compounds in Crocus sativus L. corms and its antioxidant activities study. |
| PubMed:Crocetin: an agent derived from saffron for prevention and therapy for cancer. |
| PubMed:A new validated SPE-HPLC method for monitoring crocetin in human plasma--application after saffron tea consumption. |
| PubMed:Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. |
| PubMed:Molecular cloning and characterisation of a pathogenesis-related protein CsPR10 from Crocus sativus. |
| PubMed:Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). |
| PubMed:Herbal treatments for alleviating premenstrual symptoms: a systematic review. |
| PubMed:Effect of crocus sativus on gentamicin induced nephrotoxicity. |
| PubMed:Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction. |
| PubMed:Crocus sativus L. (saffron) attenuates isoproterenol-induced myocardial injury via preserving cardiac functions and strengthening antioxidant defense system. |
| PubMed:Picrocrocin kinetics in aqueous saffron spice extracts (Crocus sativus L.) upon thermal treatment. |
| PubMed:Use of in vitro assays to assess the potential antiproliferative and cytotoxic effects of saffron (Crocus sativus L.) in human lung cancer cell line. |
| PubMed:Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup. |
| PubMed:In vitro development of microcorms and stigma like structures in saffron (Crocus sativus L.). |
| PubMed:DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from kashmiri saffron in a human pancreatic cancer cell line. |
| PubMed:Crocetin from the tubular calyx of Nyctanthes arbor-tristis. |
| PubMed:Role of saffron (Crocus sativus L.) and honey syrup on aluminum-induced hepatotoxicity. |
| PubMed:Selective Th2 Upregulation by Crocus sativus: A Neutraceutical Spice. |
| PubMed:Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. |
| PubMed:Microwave assisted extraction of phenolic compounds from four different spices. |
| PubMed:Evaluation of Crocus sativus L. stigma phenolic and flavonoid compounds and its antioxidant activity. |
| PubMed:The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease. |
| PubMed:Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial. |
| PubMed:New applications and mechanisms of action of saffron and its important ingredients. |
| PubMed:A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. |
| PubMed:Comparative analysis of pistil transcriptomes reveals conserved and novel genes expressed in dry, wet, and semidry stigmas. |
| PubMed:Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheime |
