| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 79-09-4 |
| ECHA EC Number: | 201-176-3 |
| FDA UNII: | JHU490RVYR |
| CoE Number: | 3 |
| Category: | sanitizing agents for food processing equipment, flavoring agents |
| IUPAC Name: | propionic acid |
| InChI : | InChI=1/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5) |
| Std.InChI: | InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5) |
| InChIKey : | XBDQKXXYIPTUBI-UHFFFAOYAP |
| Std.InChIKey: | XBDQKXXYIPTUBI-UHFFFAOYSA-N |
| SMILES : | CCC(=O)O |
| MDL: | MFCD00002756 |
| Molar Refractivity : | 17.51 ± 0.3 cm3 (est) |
| Parachor : | 173.3 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.397 ± 0.02 (est) |
| Surface Tension : | 32.3 ± 3.0 dyne/cm (est) |
| Density : | 1.019 ± 0.06 g/cm3 (est) |
| Polarizability : | 6.94 ± 0.5 10-24cm3 (est) |
| Fragrance Demo Formulas | |
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA/DG SANTE Petitions, Reviews, Notices: | |
| 184.1081 | Propionic acid View - review |
| EU SANCO | Propionic acid View - review |
| EU SANCO | Propionic acid - propionates View - review |
| JECFA Food Flavoring: | 84 propionic acid |
| JECFA Food Additive: | Propionic Acid |
| GSFA Codex: | Propionic acid (280) |
| DG SANTE Food Flavourings: | 08.003 propionic acid |
| DG SANTE Food Additives: | propionic acid |
| DG SANTE Food Contact Materials: | propionic acid |
| FEMA Number: | 2924 propionic acid |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 79-09-4 ; PROPIONIC ACID |
| FDA Regulation: | |
| FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS Subpart B--Substances Utilized To Control the Growth of Microorganisms Sec. 178.1010 Sanitizing solutions. FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE Subpart B--Listing of Specific Substances Affirmed as GRAS Sec. 184.1081 Propionic acid. | |
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 99.00 to 100.00 |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 0.99000 to 1.00000 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 8.238 to 8.321 |
| Refractive Index: | 1.38500 to 1.38900 @ 20.00 °C. |
| Melting Point: | -24.00 to -23.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 140.00 to 141.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 70.00 to 71.00 °C. @ 50.00 mm Hg |
| Vapor Pressure: | 4.227000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 2.56 ( Air = 1 ) |
| Flash Point: | 129.00 °F. TCC ( 53.89 °C. ) |
| logP (o/w): | 0.330 |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: | |
| alcohol | |
| water, 1.736e+005 mg/L @ 25 °C (est) | |
| oils | |
| propylene glycol | |
| water, 1.00E+06 mg/L @ 25 °C (exp) | |
| Similar Items:note | |
| acetic acid | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | preservatives |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| C - Corrosive. | |
| R 10 - Flammable. R 34 - Causes burns. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 2600 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 110, 1974. intravenous-mouse LD50 625 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica. Vol. 18, Pg. 141, 1961. intravenous-rabbit LD50 1320 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 110, 1974. oral-mammal (species unspecified) LD50 1640 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974. unreported-mouse LD50 1370 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: EXCITEMENTBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 96, 1970. unreported-rabbit LD50 1900 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: EXCITEMENTBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 96, 1970. intravenous-rabbit LDLo 1320 mg/kg FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 110, 1974. parenteral-rat LD50 3500 mg/kg Defense des Vegetaux. Vol. 26, Pg. 5, 1972. unreported-rat LD50 1510 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: EXCITEMENTLUNGS, THORAX, OR RESPIRATION: DYSPNEA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(3), Pg. 96, 1970. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 500 ul/kg American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| sanitizing agents for food processing equipment, flavoring agents | |||
| Recommendation for propionic acid usage levels up to: | |||
| not for fragrance use. | |||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3. Update in publication number(s): 29 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 200.00000 | 500.00000 | |
| beverages(nonalcoholic): | 50.00000 | 500.00000 | |
| beverages(alcoholic): | 0.01000 | 0.01000 | |
| breakfast cereal: | 50.00000 | 500.00000 | |
| cheese: | 100.00000 | 600.00000 | |
| chewing gum: | 100.00000 | 300.00000 | |
| condiments / relishes: | 100.00000 | 500.00000 | |
| confectionery froastings: | - | - | |
| egg products: | 50.00000 | 500.00000 | |
| fats / oils: | 50.00000 | 500.00000 | |
| fish products: | 50.00000 | 500.00000 | |
| frozen dairy: | 50.00000 | 500.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | 100.00000 | 500.00000 | |
| hard candy: | 14.00000 | 14.00000 | |
| imitation dairy: | 50.00000 | 500.00000 | |
| instant coffee / tea: | 100.00000 | 500.00000 | |
| jams / jellies: | - | - | |
| meat products: | 50.00000 | 500.00000 | |
| milk products: | 50.00000 | 500.00000 | |
| nut products: | 50.00000 | 500.00000 | |
| other grains: | - | - | |
| poultry: | 50.00000 | 500.00000 | |
| processed fruits: | - | - | |
| processed vegetables: | 50.00000 | 500.00000 | |
| reconstituted vegetables: | 50.00000 | 500.00000 | |
| seasonings / flavors: | 50.00000 | 500.00000 | |
| snack foods: | 50.00000 | 500.00000 | |
| soft candy: | 0.01000 | 0.01000 | |
| soups: | 50.00000 | 500.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 18 (FGE.18): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical group 6 View page or View pdf |
| Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1)[1] : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8 View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25 View page or View pdf |
| Scientific Opinion on the safety and efficacy of propionic acid, sodium propionate, calcium propionate and ammonium propionate for all animal species View page or View pdf |
| Scientific Opinion on safety and efficacy of sodium benzoate, propionic acid and sodium propionate for pigs, poultry, bovines, sheep, goats, rabbits, horses View page or View pdf |
| Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species View page or View pdf |
| Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):79-09-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :1032 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WISER:UN 3463 |
| WGK Germany:1 |
| propanoic acid |
| Chemidplus:0000079094 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:79-09-4 |
| propanoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 79-09-4 |
| Pubchem (cid): | 1032 |
| Pubchem (sid): | 134971247 |
| Pherobase: | View |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00163 |
| HMDB (The Human Metabolome Database): | HMDB00237 |
| FooDB: | FDB008285 |
| Export Tariff Code: | 2915.50.1000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| FAO: | Propionic acid |
| Formulations/Preparations: •grades: technical, 99.0%; food chemicals codex•trade names: luprosil; proxoin; tenox p. | |
| For Odor |
| acidic |
2- ethyl butyric acidFL/FR |
2- methyl butyric acidFL/FR |
| cheesy |
| valeric acid FL/FR |
| fruity |
| cyclohexyl carboxylic acid FL/FR |
| methyl butyrate FL/FR |
2- nonanoneFL/FR |
| green |
iso butyl methyl ketoneFL/FR |
| herbal |
1- octen-3-yl acetateFL/FR |
| medicinal |
meta- dimethyl hydroquinoneFL/FR |
| waxy |
| ethyl laurate FL/FR |
2- nonanolFL/FR |
| For Flavor |
| No flavor group found for these |
(Z)-3- hexenoic acidFL |
S-( methyl thio) hexanoateFL |
| acidic |
| acidic |
2- ethyl butyric acidFL/FR |
| valeric acid FL/FR |
| cheesy |
2- nonanoneFL/FR |
| chemical |
meta- dimethyl hydroquinoneFL/FR |
| fruity |
| banana cream flavor FL |
| cyclohexyl carboxylic acid FL/FR |
2- methyl butyric acidFL/FR |
| fusel |
| methyl butyrate FL/FR |
| green |
iso butyl methyl ketoneFL/FR |
| heptanal 2,3-butane diol acetal FL |
1- octen-3-yl acetateFL/FR |
| sour |
2,4- dimethyl-2-pentenoic acidFL |
3- methyl valeric acidFL |
| waxy |
| ethyl laurate FL/FR |
2- nonanolFL/FR |
| anise seed Search Trop Picture | |
| apple fruit Search PMC Picture | |
| avocado fruit Search Trop Picture | |
| barley roasted barley Search Trop Picture | |
| basil oil Search Trop Picture | |
| bay laurel leaf Search Trop Picture | |
| bread wheat bread Search PMC Picture | |
| burdock plant Search Trop Picture | |
| cacao bean seed Search Trop Picture | |
| cajuput Search Trop Picture | |
| cheese @ 60.00 ± 5 mmol% Data GC Search PMC Picture | |
| cheese bleu cheese Search PMC Picture | |
| cheese cheddar cheese Search PMC Picture | |
| cheese swiss cheese Search PMC Picture | |
| coffee Search PMC Picture | |
| ginkgo biloba fruit Search Trop Picture | |
| lavender Search Trop Picture | |
| milk Search PMC Picture | |
| onion roasted onion Search Trop Picture | |
| orange plant Search Trop Picture | |
| osmanthus absolute @ 0.02% Data GC Search Trop Picture | |
| pepper bell pepper fruit Search Trop Picture | |
| pork cooked pork Search PMC Picture | |
| raspberry red raspberry fruit Search Trop Picture | |
| roselle fruit Search Trop Picture | |
| roselle seed Search Trop Picture | |
| soybean seed Search Trop Picture | |
| tea leaf Search Trop Picture | |
| tobacco virginia tobacco Search Picture | |
| tomato fruit Search Trop Picture | |
| whiskey Search Picture | |
| wine Search Picture | |
| yogurt Search Picture |
| pseudo | acetic acid |
| acide propanoique | |
| acide propionique | |
| carboxyethane | |
| meta | cetonic acid |
| ethane carboxylic acid | |
| ethanecarboxylic acid | |
| ethyl formic acid | |
| ethylformic acid | |
| hydroacrylic acid | |
| 1- | hydroxy-1-oxopropane |
| luprosil | |
| methyl acetic acid | |
| methylacetic acid | |
| monoprop | |
| propanoic acid | |
| propanyl acid | |
| propioic acid | |
| N- | propionic acid |
| nat. | propionic acid |
| propionic acid natural | |
| propionic acid pure | |
| propionic acid, food grade | |
| propionic acid, natural | |
| propionicacid | |
| propionoic acid | |
| propionsaeure | |
| propkorn | |
| prozoin |
