| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 78-93-3 |
| ECHA EC Number: | 201-159-0 |
| FDA UNII: | 6PT9KLV9IO |
| CoE Number: | 753 |
| Category: | extraction solvents, flavoring agents |
| IUPAC Name: | methyl ethyl ketone |
| InChI : | InChI=1/C4H8O/c1-3-4(2)5/h3H2,1-2H3 |
| Std.InChI: | InChI=1S/C4H8O/c1-3-4(2)5/h3H2,1-2H3 |
| InChIKey : | ZWEHNKRNPOVVGH-UHFFFAOYAW |
| Std.InChIKey: | ZWEHNKRNPOVVGH-UHFFFAOYSA-N |
| SMILES : | CCC(=O)C |
| MDL: | MFCD00011648 |
| Molar Refractivity : | 20.60 ± 0.3 cm3 (est) |
| Parachor : | 196.3 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.367 ± 0.02 (est) |
| Surface Tension : | 21.0 ± 3.0 dyne/cm (est) |
| Density : | 0.786 ± 0.06 g/cm3 (est) |
| Polarizability : | 8.17 ± 0.5 10-24cm3 (est) |
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.50 to 100.00 |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 0.80100 to 0.80300 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 6.665 to 6.682 |
| Refractive Index: | 1.37700 to 1.38000 @ 20.00 °C. |
| Melting Point: | -85.00 to -87.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 78.60 to 80.00 °C. @ 760.00 mm Hg |
| Acid Value: | 2.00 max. KOH/g |
| Vapor Pressure: | 90.600000 mmHg @ 25.00 °C. |
| Vapor Density: | 2.49 ( Air = 1 ) |
| Flash Point: | 26.00 °F. TCC ( -3.33 °C. ) |
| logP (o/w): | 0.290 |
| Soluble in: | |
| alcohol | |
| fixed oils | |
| water, 2.23E+05 mg/L @ 25 °C (exp) | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | perfuming agents solvents |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 11 - Highly flammable. R 36 - Irritating to eyes. R 66 - Repeated exposure may cause skin dryness or cracking. R 67 - Vapours may cause frowsiness and dizziness. S 09 - Keep container in a well-ventilated place. S 16 - Keep away from sources of ignition - No Smoking. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 [sex: M] 5490 mg/kg (Smyth et al., 1962) oral-rat LD50 2730 mg/kg (Kimura et al., 1971a) oral-rat LD50 3980 mg/kg (Union Carbide Corp., 1956) oral-rat LD50 [sex: F] 5525 mg/kg (Pozzani et al., 1959) oral-mouse LD50 [sex: M] 3137 mg/kg (Zakhari et al., 1977) oral-mouse LD50 [sex: M] 4050 mg/kg (Tanii et al., 1986) intraperitoneal-guinea pig LDLo 2000 mg/kg LIVER: OTHER CHANGES Food and Cosmetics Toxicology. Vol. 15, Pg. 627, 1977. intraperitoneal-mouse LD50 616 mg/kg Shell Chemical Company. Unpublished Report. Vol. -, Pg. 6, 1961. oral-mouse LD50 4050 mg/kg Toxicology Letters. Vol. 30, Pg. 13, 1986. intraperitoneal-rat LD50 607 mg/kg Environmental Research. Vol. 40, Pg. 411, 1986. oral-rat LD50 2737 mg/kg Toxicology and Applied Pharmacology. Vol. 19, Pg. 699, 1971. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 6480 mg/kg Shell Chemical Company. Vol. MSDS-5390-4 | |
| Inhalation Toxicity: | |
| inhalation-muskrat LC50 32 gm/M3/4hour CUTOEX 1,47,1993 inhalation-human TCLo 100 ppm/5M LUNGS, THORAX, OR RESPIRATION: OTHER CHANGESSENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYESENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943. inhalation-mammal (species unspecified) LC50 38000 mg/m3 Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986. inhalation-mouse LC50 32000 mg/m3/4H Current Toxicology. Vol. 1, Pg. 47, 1993. inhalation-rat LC50 23500 mg/m3/8H American Industrial Hygiene Association Journal. Vol. 20, Pg. 364, 1959. | |
| Category: | |||
| extraction solvents, flavoring agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for methyl ethyl ketone usage levels up to: | |||
| 0.5000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 96.00 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 100.00000 | |
| beverages(nonalcoholic): | - | 70.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 270.00000 | |
| fruit ices: | - | 270.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 100.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 View page or View pdf |
| Flavouring Group Evaluation 63 (FGE.63): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th meeting) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission View page or View pdf |
| Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 View page or View pdf |
| Safety and efficacy of saturated and unsaturated aliphatic secondary alcohols, ketones and esters with esters containing secondary alcohols belonging to chemical group 5 when used as flavourings for all animal species View page or View pdf |
| Risk Assessment of Food Contact Materials View page or View pdf |
| EPI System: View |
| EPA-Iris:IRIS |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):78-93-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6569 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 1193 |
| WGK Germany:1 |
| butan-2-one |
| Chemidplus:0000078933 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:78-93-3 |
| butan-2-one | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 78-93-3 |
| Pubchem (cid): | 6569 |
| Pubchem (sid): | 134971088 |
| Flavornet: | 78-93-3 |
| Pherobase: | View |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C02845 |
| HMDB (The Human Metabolome Database): | HMDB00474 |
| FooDB: | FDB003383 |
| Export Tariff Code: | 2914.12.00.00 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •usepaopp pesticide code 044103; trade names: meetco.•grades of purity: 99.5+%•grade: technical | |
| FL | banana |
| FL | bread white bread |
| FL | carrot |
| FL | cheese cheddar cheese |
| FL | cheese swiss cheese |
| FL | coffee |
| FL | cream |
| FL | dairy |
| FL | fish |
| FL | grape |
| solvents | |
| FL | tea black tea |
| FL | tomato |
| FL | yogurt |
| apple fruit Search Trop Picture | |
| apple fruit juice Search Trop Picture | |
| bread white bread Search PMC Picture | |
| butter Search PMC Picture | |
| cabbage leaf Search Trop Picture | |
| carrot Search Trop Picture | |
| cheese cheddar cheese Search PMC Picture | |
| cheese swiss cheese Search PMC Picture | |
| coffee Search PMC Picture | |
| currant black currant fruit Search Trop Picture | |
| fish Search PMC Picture | |
| guava fruit Search Trop Picture | |
| pear plant Search Trop Picture | |
| pepper bell pepper fruit Search Trop Picture | |
| peppermint oil Search Trop Picture | |
| plum fruit Search Trop Picture | |
| potato chip Search PMC Picture | |
| tea black tea Search Trop Picture | |
| tea leaf Search Trop Picture | |
| tomato fruit Search Trop Picture | |
| truffle Search Picture | |
| yogurt Search Picture |
| acetylethane | |
| butan-2-one | |
| 2-oxo | butane |
| 2- | butanone |
| 2- | butanone (methyl ethyl ketone) natural |
| ethyl methyl cetone | |
| ethyl methyl ketone | |
| ethylmethyl ketone | |
| ethylmethylketone | |
| ketone C-4 | |
| ketone, ethyl methyl | |
| MEK | |
| methyl acetone | |
| methyl ethyl cetone | |
| methyl ethyl ketone, natural | |
| methyl propanal | |
| methyl-ethyl-ketone | |
| methylacetone | |
| methylethyl ketone | |
| methylethylketone |
