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triethyl phosphate

solvents
2D:
3D:
CAS Number: 78-40-0
ECHA EC Number: 201-114-5
FDA UNII: QIH4K96K7J
Category: solvents
IUPAC Name: triethyl phosphate
InChI : InChI=1/C6H15O4P/c1-4-8-11(7,9-5-2)10-6-3/h4-6H2,1-3H3
Std.InChI: InChI=1S/C6H15O4P/c1-4-8-11(7,9-5-2)10-6-3/h4-6H2,1-3H3
InChIKey : DQWPFSLDHJDLRL-UHFFFAOYAA
Std.InChIKey: DQWPFSLDHJDLRL-UHFFFAOYSA-N
SMILES : CCOP(=O)(OCC)OCC
MDL: MFCD00009077
Molar Refractivity : 41.95 ± 0.3 cm3 (est)
Parachor : 401.9 ± 4.0 cm3 (est)
Index of Refraction : 1.405 ± 0.02 (est)
Surface Tension : 30.6 ± 3.0 dyne/cm (est)
Density : 1.066 ± 0.06 g/cm3 (est)
Polarizability : 16.63 ± 0.5 10-24cm3 (est)

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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NCBI:Search
FDA Mainterm (IAUFC):78-40-0 ; TRIETHYL PHOSPHATE

Physical Properties:

Appearance:colorless clear liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.06700 to 1.07200 @ 20.00 °C.
Pounds per Gallon - (est).: 8.889 to 8.931
Refractive Index:1.40370 @ 25.00 °C.
Melting Point: -56.00 °C. @ 760.00 mm Hg
Boiling Point: 208.00 to 209.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.177000 mmHg @ 25.00 °C. (est)
Vapor Density:6.28 ( Air = 1 )
Flash Point: 210.00 °F. TCC ( 99.00 °C. )
logP (o/w): 0.800
Soluble in:
water, 500000 mg/L @ 25 °C (exp)

Cosmetic Information:

CosIng:cosmetic data
Cosmetic Uses: solvents

Suppliers:

BOC Sciences
For experimental / research use only.
Triethyl phosphate >98.0%(GC)
Charkit Chemical
TRIETHYL PHOSPHATE
Connect Chemicals
Triethyl Phosphate
Covalent Chemical
Triethyl Phosphate
Eastman Chemical
Eastman™ Triethyl Phosphate
Odor: characteristic
Use: Eastman™ TEP (Triethyl Phosphate) is a clear, colorless liquid having a mild pleasant odor. TEP is useful as a solvent in many applications, as a plasticizer for tough, fire-resistant plastics, and as an agricultural chemical as an intermediate in preparing tetraethyl pyrophosphate (TEPP).
EMD Millipore
For experimental / research use only.
Triethyl Phosphate
Santa Cruz Biotechnology
For experimental / research use only.
Triethyl Phosphate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Triethyl phosphate ReagentPlus®, ≥99.8%
TCI AMERICA
For experimental / research use only.
Triethyl Phosphate >99.0%(GC)

Safety Information:

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1165 mg/kg
BEHAVIORAL: ATAXIABRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNSBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 227, 1999.

intraperitoneal-guinea pig LD50 800 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 605, 1969.

oral-guinea pig LD50 1600 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 605, 1969.

intraperitoneal-mouse LD50 485 mg/kg
Therapie. Vol. 15, Pg. 237, 1960.

oral-mouse LD50 1180 mg/kg
BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNSBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 227, 1999.

intraperitoneal-rat LD50 800 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 605, 1969.

intravenous-rat LDLo 1000 mg/kg
BEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: GENERAL ANESTHETICLUNGS, THORAX, OR RESPIRATION: DYSPNEA
Nature. Vol. 179, Pg. 154, 1957.

Dermal Toxicity:
skin-guinea pig LD50 > 20 ml/kg
National Technical Information Service. Vol. OTS0528351

Inhalation Toxicity:
inhalation-mouse LC > 44300 ug/m3/4
"Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 227, 1999.

inhalation-rat LCLo 28000 ppm/6H
American Industrial Hygiene Association Journal. Vol. 34, Pg. 286, 1973.

Safety in Use Information:

Category:
solvents
Recommendation for triethyl phosphate usage levels up to:
not for fragrance use.
Recommendation for triethyl phosphate flavor usage levels up to:
not for flavor use.

Safety References:

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):78-40-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6535
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
triethyl phosphate
Chemidplus:0000078400
EPA/NOAA CAMEO:hazardous materials
RTECS:TC7900000 for cas# 78-40-0

References:

triethyl phosphate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:78-40-0
Pubchem (cid):6535
Pubchem (sid):134970757

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB12228
YMDB (Yeast Metabolome Database):YMDB02306
Export Tariff Code:2919.90.5050
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
grade: technical 97%

Potential Blenders and core components :

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):

not found in nature

Synonyms:

phosphoric acid triethyl ester
o-phosphoric acid triethyl ester
phosphoric acid, triethyl ester
triethoxyphosphine oxide
triethylphosphate

Articles:

PubMed:Occurrence and risk assessment of organophosphate esters in drinking water from Eastern China.
PubMed:Growth and alkaline phosphatase activity of Chattonella marina and Heterosigma akashiwo in response to phosphorus limitation.
PubMed:Sonochemical precipitation of amorphous uranium phosphates from trialkyl phosphate solutions and their thermal conversion to UP2O7.
PubMed:Desorption electrospray ionization-mass spectrometric analysis of low vapor pressure chemical particulates collected from a surface.
PubMed:Tris(2-butoxyethyl)phosphate and triethyl phosphate alter embryonic development, hepatic mRNA expression, thyroid hormone levels, and circulating bile acid concentrations in chicken embryos.
PubMed:Characterization and nanomechanical properties of novel dental implant coatings containing copper decorated-carbon nanotubes.
PubMed:High-separation efficiency micro-fabricated multi-capillary gas chromatographic columns for simulants of the nerve agents and blister agents.
PubMed:Dispersive liquid-liquid microextraction combined with ultrahigh performance liquid chromatography/tandem mass spectrometry for determination of organophosphate esters in aqueous samples.
PubMed:Microwave-assisted extraction combined with gel permeation chromatography and silica gel cleanup followed by gas chromatography-mass spectrometry for the determination of organophosphorus flame retardants and plasticizers in biological samples.
PubMed:Uptake and translocation of organophosphates and other emerging contaminants in food and forage crops.
PubMed:Investigations of chemical warfare agents and toxic industrial compounds with proton-transfer-reaction mass spectrometry for a real-time threat monitoring scenario.
PubMed:History of arsenic ethers: who was Felix D'Arcet?
PubMed:Adsorption of trimethyl phosphate and triethyl phosphate on dry and water pre-covered hematite, maghemite, and goethite nanoparticles.
PubMed:Application of PM-IRRAS to study thin films on industrial and environmental samples.
PubMed:DFT investigations of phosphotriesters hydrolysis in aqueous solution: a model for DNA single strand scission induced by N-nitrosoureas.
PubMed:Benzene removal by a novel modification of enhanced anaerobic biostimulation.
PubMed:Non-contact detection of chemical warfare simulant triethyl phosphate using PM-IRRAS.
PubMed:Bioactive silica-based drug delivery systems containing doxorubicin hydrochloride: in vitro studies.
PubMed:Occurrence and fate of organophosphorus flame retardants and plasticizers in coastal and marine surface waters.
PubMed:Dust as a collection media for contaminant source attribution.
PubMed:Infrared multiple photon dissociation action spectroscopy and theoretical studies of triethyl phosphate complexes: effects of protonation and sodium cationization on structure.
PubMed:Volatile constituents, inorganic elements and primary screening of bioactivity of black coral cigarette holders.
PubMed:Analytical developments and preliminary assessment of human exposure to organophosphate flame retardants from indoor dust.
PubMed:Gas-phase synchrotron FTIR spectroscopy of weakly volatile alkyl phosphonate and alkyl phosphate compounds: vibrational and conformational analysis in the terahertz/far-IR spectral domain.
PubMed:Mechanical properties and in vitro bioactivity of Ca5(PO4)2SiO4 bioceramic.
PubMed:History of organophosphate synthesis: the very early days.
PubMed:Crystallographically engineered, hydrothermally crystallized hydroxyapatite films: an in vitro study of bioactivity.
PubMed:History of methyl phosphoric esters: Hall, Weger, and Lossen.
PubMed:Plasma chemical degradation of phosphorous-containing warfare agents simulants.
PubMed:In vitro apatite formation on organic-inorganic hybrids in the CaO-SiO(2)-PO (5/2)-poly(tetramethylene oxide) system.
PubMed:Modeling metal cation-phosphate interactions in nucleic acids: activated dissociation of Mg+, Al+, Cu+, and Zn+ complexes of triethyl phosphate.
PubMed:Optofluidic ring resonator sensors for rapid DNT vapor detection.
PubMed:The synthesis of some perhydrobenzimidazolinium salts and their application in pd-carbene catalyzed heck and suzuki reactions.
PubMed:The effects of chronic inorganic and organic phosphate exposure on bactericidal activity of the coelomic fluid of the sea urchin Lytechinus variegatus (Lamarck) (Echinodermata: Echinoidea).
PubMed:The synthesis of phosphor ethers: who was Franz Anton Voegeli?
PubMed:Genotoxicity studies of a desealant solvent mixture, SR-51.
PubMed:Synthesis of high purity hydroxyapatite nanopowder via sol-gel combustion process.
PubMed:Oil red-O stains non-adipogenic cells: a precautionary note.
PubMed:Characterization and utilization of a novel triflate ionic liquid stationary phase for use in comprehensive two-dimensional gas chromatography.
PubMed:Gas-phase vibrational spectroscopy and ab initio study of organophosphorus compounds: discrimination between species and conformers.
PubMed:Rate constants for the gas-phase reactions of OH radicals with dimethyl phosphonate over the temperature range of 278-351 K and for a series of other organophosphorus compounds at approximately 280 K.
PubMed:Modeling metal cation-phosphate interactions in nucleic acids in the gas phase via alkali metal cation-triethyl phosphate complexes.
PubMed:Multi-encoded rugate porous silicon as nerve agents sensors.
PubMed:Development of a thermal evaporation cell for gas-phase infrared absorption spectroscopy of compounds with low volatility.
PubMed:Detection of chemical weapon agents and simulants using chemical ionization reaction time-of-flight mass spectrometry.
PubMed:Effects of triethyl phosphate and nitrate on electrokinetically enhanced biodegradation of diesel in low permeability soils.
PubMed:Activation of the binuclear metal center through formation of phosphotriesterase-inhibitor complexes.
PubMed:Kinetic and product study of the gas-phase reactions of OH radicals, NO(3) radicals, and O(3) with (C(2)H(5)O)(2)P(S)CH(3) and (C(2)H(5)O)(3)PS.
PubMed:Synthesis of ordered mesoporous zirconium phosphate films by spin coating and vapor treatments.
PubMed:Atmospheric chemistry of diethyl methylphosphonate, diethyl ethylphosphonate, and triethyl phosphate.
PubMed:Temperature-dependent rate constants for the gas-phase reactions of OH radicals with 1,3,5-trimethylbenzene, triethyl phosphate, and a series of alkylphosphonates.
PubMed:Functional effects of amino acid substitutions within the large binding pocket of the phosphotriesterase OpdA from Agrobacterium sp. P230.
PubMed:Liquid chromatography electrospray tandem mass spectrometric and desorption electrospray ionization tandem mass spectrometric analysis of chemical warfare agents in office media typically collected during a forensic investigation.
PubMed:The synthesis, structural, and spectroscopic characterization of uranium(IV) perrhenate complexes.
PubMed:Indoor sorption of surrogates for sarin and related nerve agents.
PubMed:[Identification of unknown peaks in foods during residual pesticide analysis].
PubMed:Evaluation of solid-phase microextraction with PDMS for air sampling of gaseous organophosphate flame-retardants and plasticizers.
PubMed:Two-dimensional nonlinear wavelet compression of ion mobility spectra of chemical warfare agent simulants.
PubMed:Detection, identification, and estimation of biological aerosols and vapors with a Fourier-transform infrared spectrometer.
PubMed:Flame retardants in the indoor environment -- Part II: release of VOCs (triethylphosphate and halogenated degradation products) from polyurethane.
PubMed:Phase purity of sol-gel-derived hydroxyapatite ceramic.
PubMed:The effects of organic and inorganic phosphates on fertilization and early development in the sea urchin Lytechinus variegatus (Echinodermata: Echinoidea).
PubMed:A convenient synthesis of a novel nucleoside analogue: 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone.
PubMed:The binding of substrate analogs to phosphotriesterase.
PubMed:[Synthesis and antiherpes activity of acyclovir phosphoesters].
PubMed:The synthesis of galactopyranosyl derivatives with beta-galactosidases of different origins.
PubMed:The anatomic basis for arteriovenous shunting in human lower leg fascial flaps.
PubMed:Solution structure of lariat RNA by 500 MHz NMR spectroscopy and molecular dynamics studies in water.
PubMed:[Hygienic substantiation of maximum permissible level of triethylphosphate in reservoir water].
PubMed:Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds.
PubMed:A new efficient synthetic method for 2- and 4-hydroxy-17 alpha-ethynylestradiol.
PubMed:The quantitative determination of metabolites of 6-mercaptopurine in biological materials. VII. Chemical synthesis by phosphorylation of 6-thioguanosine 5'-monophosphate, 5'-diphosphate and 5'-triphosphate, and their purification and identification by reversed-phase/ion-pair high-performance liquid chromatography and by various enzymatic assays.
PubMed:Synthesis and biological evaluation of some phosphate triester derivatives of the anti-cancer drug araC.
PubMed:Physical basis of the effect of hemoglobin on the 31P NMR chemical shifts of various phosphoryl compounds.
PubMed:The contribution of magnetic susceptibility effects to transmembrane chemical shift differences in the 31P NMR spectra of oxygenated erythrocyte suspensions.
PubMed:Induction of the hepatic microsomal cytochrome P-450 system by trialkyl phosphorothioates in rats.
PubMed:Toxicity of several phosphoric acid esters in rats.
PubMed:Lipophilic 5'-(alkyl phosphate) esters of 1-beta-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugs.
PubMed:Double-column gas chromatography using packed pre-columns and glass capillary main columns.
PubMed:Synthesis and biological activity of N6-(n-alkylureido)purine ribonucleosides and their 5'-phosphates.
PubMed:Synthesis and antitumor activity of 5'-phosphates and cyclic 3',5'-phosphates derived from biologically active nucleosides.
PubMed:Aliphatic analogues of nucleotides: synthesis and affinity towards nucleases.
PubMed:Optical-rotatory-dispersion studies of compounds related to cholesterol in liposomes and the membranes of erythrocyte 'ghosts'.
PubMed:Metabolic factors which influence triethyl phosphate-induced narcosis in rats.
PubMed:Factors influencing dimethoate and triethyl phosphate-induced narcosis in rats and mice.
PubMed:Anticholinesterase activity of triethyl phosphate resulting from an impurity.
PubMed:Analogues of ribose 5-phosphate and 5-phosphoribosyl pyrophosphate. The preparation and properties of ribose 5-phosphorothioate and 5-phosphoribosyl 1-methylenediphosphonate.
PubMed:The dipole moments of diethyl sulfite, triethyl phosphate and tetraethyl silicate.
PubMed:The use of dimethoxytetraethyleneglycol and triethyl phosphate in histological technic.
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