| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 7558-79-4 |
| ECHA EC Number: | 231-448-7 |
| FDA UNII: | 22ADO53M6F |
| Category: | multiple purpose GRAS food substances, acidity regulators |
| IUPAC Name: | disodium phosphate |
| InChI : | InChI=1/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2/f2Na.HO4P/h;;1H/q2m;-2 |
| Std.InChI: | InChI=1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2 |
| InChIKey : | BNIILDVGGAEEIG-SQYQQCHWCR |
| Std.InChIKey: | BNIILDVGGAEEIG-UHFFFAOYSA-L |
| SMILES : | OP(=O)([O-])[O-].[Na+].[Na+] |
| MDL: | MFCD00003496 |
| Appearance: | white crystalline powder (est) |
| Assay: | 95.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 240.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 158.00 °C. @ 760.00 mm Hg (est) |
| PH Number: | 8.90 |
| Vapor Pressure: | 1.410000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.9 ( Air = 1 ) |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w): | -2.148 (est) |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. store under nitrogen. |
| Storage: | store under nitrogen. |
| Soluble in: | |
| water, 1e+006 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| alcohol | |
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 17000 mg/kg Sigma-Aldrich intravenous-rabbit LDLo 1075 mg/kg BEHAVIORAL: TETANY Handbuch der Experimentellen Pharmakologie. Vol. 10, Pg. 361, 1950. oral-rat LD50 17000 mg/kg "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 16, 1972. intramuscular-rat LDLo 1000 mg/kg Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925. intraperitoneal-rat LDLo 1000 mg/kg Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925. | |
| Dermal Toxicity: | |
| subcutaneous-rat LDLo 1000 mg/kg Biochemische Zeitschrift. Vol. 163, Pg. 226, 1925. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| multiple purpose GRAS food substances, acidity regulators | |||
| Recommendation for disodium phosphate usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 2300.00000 | |
| beverages(nonalcoholic): | - | 350.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 350.00000 | |
| fruit ices: | - | 350.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 50.00000 | 250.00000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Authority (EFSA) reference(s): |
| Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials View page or View pdf |
| Assessment of one published review on health risks associated with phosphate additives in food View page or View pdf |
| Re-evaluation of phosphoric acid�phosphates � di-, tri- and polyphosphates (E 338�341, E 343, E 450�452) as food additives and the safety of proposed extension of use View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):7558-79-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :24203 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 3077 |
| WGK Germany:1 |
| disodium hydrogen phosphate |
| Chemidplus:0007558794 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:7558-79-4 |
| disodium hydrogen phosphate | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 7558-79-4 |
| Pubchem (cid): | 24203 |
| Pubchem (sid): | 134986680 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C13558 |
| HMDB (The Human Metabolome Database): | Search |
| FooDB: | FDB013359 |
| Export Tariff Code: | 2835.22.0000 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •sodium phosphates injection, usp, 3 mm pml (millimolesml)each ml contains 276 mg of monobasic sodium phosphate, monohydrate and 142 mg of dibasic sodium phosphate, anhydrous (equivalent to 268 mg of dibasic sodium phosphate, heptahydrate). it contains no bacteriostat, antimicrobial agent or added buffer.•sodium phosphate preparations: (ahfs, 2009) sodium phosphate preparations: (ahfs, 2009)route dosage form strength brand or generic name (manufacturer) tablet dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g osmoprep (salix) tablet dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g visicol (salix) rectal solution dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml fleet enema (fleet) rectal solution dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml fleet pediatric enema (fleet) •visicol (sodium phosphate monobasic monohydrate, usp, and sodium phosphate dibasic anhydrous, usp)each tablet contains 1.102 grams of sodium phosphate monobasic monohydrate, usp and 0.398 grams of sodium phosphate dibasic anhydrous, usp for a total of 1.5 grams of sodium phosphate per tablet. inert ingredients include microcrystalline cellulose (mcc), nf; magnesium stearate, nf; and colloidal silicon dioxide, nf. visicol is gluten-free.•sodium phosphate and sodium biphosphate enema usp dosage forms-- enema usp: 6% sodium phosphate and 16% sodium biphosphate; sodium phosphate and sodium biphosphate oral solution usp dosage forms-- solution usp: 18% sodium phosphate and 48% sodium biphosphate.•sorensen's phosphate, sorensen's sodium phosphate. disodium phosphate dihydrate•fleet's enema: solution (sodium phosphate 6 g and sodium biphosphate 16 g). fleet's phospho-soda: (sodium phosphate 18 g and sodium biphosphate 48 g).•an oral soln (fleet phospho-soda) contains 1.8 g of dibasic sodium phosphate and 4.8 g of monobasic sodium phosphate in 10 ml saline laxatives•grade: commercial, nf national formulary grade of chemical (sodium phosphate, dibasic anhydrous and heptahydrate), fcc food chemicals codex (sodium phosphate, dibasic anhydrous or dihydrate)•available as anhydrous or dihydric salts. | |
| None Found |
| anticorrosive agents | |
| buffering agents |
| not found in nature |
| disodium hydrogen phosphate | |
| disodium phosphate (food grade) | |
| disodium phosphate anhydrous | |
| disodium phosphate anhydrous FCC granular | |
| phosphoric acid disodium salt | |
| sodium monohydrogen phosphate (2:1:1) | |
| sodium phosphate (NaHPO4) | |
| sodium phosphate dibasic | |
| sodium phosphate dibasic anhydrous ACS | |
| sodium phosphate dibasic anhydrous powder FCC | |
| sodium phosphate dibasic anhydrous ultra pure | |
| sodium phosphate dibasic anhydrous USP | |
| sodium phosphate dibasic dried powder USP/NF | |
| sodium phosphate, di |
| None found yet. Try the PubMed Search. |
