| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 75-09-2 |
| ECHA EC Number: | 200-838-9 |
| FDA UNII: | 588X2YUY0A |
| Category: | extraction solvents |
| IUPAC Name: | dichloromethane |
| InChI : | InChI=1/CH2Cl2/c2-1-3/h1H2 |
| Std.InChI: | InChI=1S/CH2Cl2/c2-1-3/h1H2 |
| InChIKey : | YMWUJEATGCHHMB-UHFFFAOYAG |
| Std.InChIKey: | YMWUJEATGCHHMB-UHFFFAOYSA-N |
| SMILES : | C(Cl)Cl |
| MDL: | MFCD00000881 |
| Molar Refractivity : | 16.38 ± 0.3 cm3 (est) |
| Parachor : | 148.8 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.398 ± 0.02 (est) |
| Surface Tension : | 23.1 ± 3.0 dyne/cm (est) |
| Density : | 1.252 ± 0.06 g/cm3 (est) |
| Polarizability : | 6.49 ± 0.5 10-24cm3 (est) |
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.32500 @ 25.00 °C. |
| Boiling Point: | 40.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 435.000000 mmHg @ 25.00 °C. |
| logP (o/w): | 1.250 |
| Soluble in: | |
| alcohol | |
| ether | |
| water, 1.095e+004 mg/L @ 25 °C (est) | |
| water, 1.30E+04 mg/L @ 25 °C (exp) | |
| Insoluble in: | |
| water | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | solvents |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 1600 mg/kg BEHAVIORAL: ATAXIA FAO Nutrition Meetings Report Series. Vol. 48A, Pg. 94, 1970. intraperitoneal-rat LD50 916 mg/kg Environmental Research. Vol. 40, Pg. 411, 1986. intraperitoneal-dog LD50 1274 mg/kg Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967. intravenous-dog LDLo 200 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. oral-dog LDLo 3000 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. oral-human LDLo 357 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)PERIPHERAL NERVE AND SENSATION: PARESTHESIS "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 390, 1969. oral-man TDLo 1429 uL/kg BLOOD: NORMOCYTIC ANEMIAKIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 575, 1994. intraperitoneal-mouse LD50 437 mg/kg Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 18, Pg. 109, 1960. oral-mouse LD50 873 mg/kg EHP, Environmental Health Perspectives. Vol. 106(Suppl unreported-mouse LD50 4770 mg/kg GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEGASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH Eisei Kagaku. Hygienic Chemistry. Vol. 28, Pg. P31, 1982. unreported-rabbit LD50 1225 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. oral-rabbit LDLo 1900 mg/kg "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 94, 1955. unreported-rat LD50 5350 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(6), Pg. 78, 1988. intratracheal-rat LDLo 350 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMALUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI National Technical Information Service. Vol. OTS0520615 | |
| Dermal Toxicity: | |
| subcutaneous-mouse LD50 6460 mg/kg Toxicology and Applied Pharmacology. Vol. 4, Pg. 354, 1962. subcutaneous-rabbit LDLo 2700 mg/kg Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934. | |
| Inhalation Toxicity: | |
| inhalation-rat LC50 52 gm/m3 Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979. inhalation-cat LCLo 43400 mg/m3/4. BEHAVIORAL: GENERAL ANESTHETICBEHAVIORAL: ATAXIA Archiv fuer Hygiene und Bakteriologie. Vol. 116, Pg. 131, 1936. inhalation-dog LCLo 14108 ppm/7H SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYELUNGS, THORAX, OR RESPIRATION: DYSPNEAVASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. inhalation-guinea pig LCLo 5000 ppm/2H Fluorine Chemistry Reviews. Vol. 1, Pg. 197, 1967. inhalation-human TCLo 500 ppm/1Y-I BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)CARDIAC: CHANGE IN RATE Abstracts on Hygiene. Vol. 43, Pg. 1123, 1968. inhalation-human TCLo 500 ppm/8H BEHAVIORAL: EUPHORIA Science. Vol. 176, Pg. 295, 1972. inhalation-mouse LC50 14400 ppm/7H National Institutes of Health, Bulletin. Vol. 191, Pg. 1, 1949. inhalation-rabbit LCLo 10000 ppm/7H Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 8, 1944. inhalation-rat LC50 52000 mg/m3 Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 64, 1979. | |
| Category: | |||
| extraction solvents | |||
| Recommendation for dichloromethane usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for dichloromethane flavor usage levels up to: | |||
| not for flavor use. | |||
| EPI System: View |
| EPA-Iris:IRIS |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):75-09-2 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6344 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| dichloromethane |
| Chemidplus:0000075092 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:75-09-2 |
| dichloromethane | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 75-09-2 |
| Pubchem (cid): | 6344 |
| Pubchem (sid): | 134970738 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C02271 |
| HMDB (The Human Metabolome Database): | HMDB31548 |
| FooDB: | FDB008159 |
| Export Tariff Code: | 2903.12.0000 |
| Wikipedia: | View |
| Formulations/Preparations: •dichloromethane is available as commercialtechnical grade & grades intended specifically for vapor degreasing, aerosol use, food extraction, reagent use & spectrophotometry. purity, when reported, ranges from 99-99.9% (reagenthigh performance liq chromatography grade). acidity (as hydrochloric acid) may be up to 5-10 mgkg. the max concn of water in commercial grade dichloromethane is generally 100-200 mgkg, but anhydrous dichloromethane (less than 50 mgkg water) is also available ...•small amt of stabilizers are often added to dichloromethane at the time of manufacture. cyclohexane (50 mgkg) & propylene oxide have been added to commercial aerosols & reagent grades of dichloromethane for this purpose. other reported stabilizers include 2-methyl-2-butene @ 50 mgkg, ethanol or methanol at approx 0.2%, & small quantities (1 mgkg) of phenol .•additives may include 0.0001-1% of stabilizers such as: amines, 4-cresol, hydroquinone, methanol, 2-methylbut-2-ene, 1-naphthol, nitromethane + 1,4-dioxane, phenol, resorcinol, and thymol.•in the usa, a standard grade dichloromethane has the following typical specifications: a clear, water white liquid, free of suspended matter acidity, 5 mgkg max; non volatile residue 10 mgkg max; free halogen none; & a 100% distillation range of 39.5-40.5 deg c.•grades available from mallinkrodt speciaty chemicals include ar, chomar, nanograde, spectrar, ultimar, acs reagent, usp, hplc, and gc grades. | |
| None Found |
| None Found |
| not found in nature |
| aerothene MM | |
| methylene chloride | |
| narkotil | |
| solmethine | |
| methylene bichloride | |
| methylene dichloride | |
| methylenum chloratum |
| None found yet. Try the PubMed Search. |
