| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 72-19-5 |
| ECHA EC Number: | 200-774-1 |
| FDA UNII: | 2ZD004190S |
| Category: | special dietary and nutritional additives |
| IUPAC Name: | laevo-threonine |
| InChI : | InChI=1/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 |
| Std.InChI: | InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 |
| InChIKey : | AYFVYJQAPQTCCC-GBXIJSLDBG |
| Std.InChIKey: | AYFVYJQAPQTCCC-GBXIJSLDSA-N |
| SMILES : | C[C@H]([C@@H](C(=O)O)N)O |
| MDL: | MFCD00064270 |
| Molar Refractivity : | 27.13 ± 0.3 cm3 (est) |
| Parachor : | 253.6 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.507 ± 0.02 (est) |
| Surface Tension : | 60.0 ± 3.0 dyne/cm (est) |
| Density : | 1.307 ± 0.06 g/cm3 (est) |
| Polarizability : | 10.75 ± 0.5 10-24cm3 (est) |
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 2119 L-threonine |
| FEMA Number: | 4710 L-threonine |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 72-19-5 ; L-THREONINE |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart D--Special Dietary and Nutritional Additives Sec. 172.320 Amino acids. | |
| Appearance: | white crystalline powder (est) |
| Assay: | 98.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 256.00 to 272.00 °C. @ 760.00 mm Hg |
| Flash Point: | 325.00 °F. TCC ( 162.90 °C. ) (est) |
| logP (o/w): | -2.940 |
| Soluble in: | |
| water, 2.79e+005 mg/L @ 25 °C (est) | |
| water, 9.70E+04 mg/L @ 25 °C (exp) | |
| A.M.G.L.T. |
| L-Threonine Feed Grade |
| Ajinomoto USA |
| AjiPure™ Threonine Flavor: characteristic Manufactured under cGMP conditions using no materials of animal origin. |
| Ajinomoto USA |
| L-Threonine Flavor: characteristic L-threonine is classified as an essential amino acid. Humans do not synthesize L-threonine, so it must be obtained through the diet. The male adult’s daily requirement is 7 mg per kg of body weight. Most people will get sufficient L-threonine through the diet, but as threonine content in grains is low, vegetarians are more likely than others to have deficiencies and should consider supplementation. |
| Alfa Biotechnology |
| For experimental / research use only. |
| L-Threonine 98% |
| BBFY Industrial |
| L-Threonine Feed Grade |
| BOC Sciences |
| For experimental / research use only. |
| H-Thr-OH >98% |
| Charkit Chemical |
| THREONINE, L- |
| Foodchem International |
| L-Threonine |
| Glentham Life Sciences |
| L-Threonine, GlenCell?, suitable for cell culture |
| Glentham Life Sciences |
| L-Threonine |
| Graham Chemical |
| L-Threonine |
| Indis NV |
| For experimental / research use only. |
| L-Threonine |
| OQEMA |
| Threonine |
| Penta International |
| L-THREONINE NATURAL |
| Penta International |
| L-THREONINE |
| Prinova |
| L-Threonine |
| Sigma-Aldrich |
| For experimental / research use only. |
| L-Threonine reagent grade, ≥98% (TLC) |
| TCI AMERICA |
| For experimental / research use only. |
| L-(-)-Threonine >99.0%(T) |
| The Good Scents Company |
| L-THREONINE 98.5% FEED GRADE (AS IS BASIS) Flavor: sweet ADM L-Threonine is a high quality product specifically designed for the feed industry. Produced from advanced technology, ADM L-Threonine is composed of 100% isomerically pure L-Threonine, which translates into 100% bioavailability for swine, poultry, and other animals. |
| United International |
| L-Threonine Nat. |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| None - None found. | |
| S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| intraperitoneal-rat LD50 3098 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)LUNGS, THORAX, OR RESPIRATION: DYSPNEA Archives of Biochemistry and Biophysics. Vol. 58, Pg. 253, 1955. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| special dietary and nutritional additives | |||
| Recommendation for laevo-threonine usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 25 | |||
| Click here to view publication 25 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 50.00000 | 200.00000 | |
| beverages(nonalcoholic): | 50.00000 | 200.00000 | |
| beverages(alcoholic): | 50.00000 | 200.00000 | |
| breakfast cereal: | 50.00000 | 200.00000 | |
| cheese: | 50.00000 | 200.00000 | |
| chewing gum: | 50.00000 | 200.00000 | |
| condiments / relishes: | 50.00000 | 200.00000 | |
| confectionery froastings: | 50.00000 | 200.00000 | |
| egg products: | 50.00000 | 200.00000 | |
| fats / oils: | 50.00000 | 200.00000 | |
| fish products: | 50.00000 | 200.00000 | |
| frozen dairy: | 50.00000 | 200.00000 | |
| fruit ices: | 50.00000 | 200.00000 | |
| gelatins / puddings: | 50.00000 | 200.00000 | |
| granulated sugar: | 50.00000 | 200.00000 | |
| gravies: | 50.00000 | 200.00000 | |
| hard candy: | 50.00000 | 200.00000 | |
| imitation dairy: | 50.00000 | 200.00000 | |
| instant coffee / tea: | 50.00000 | 200.00000 | |
| jams / jellies: | 50.00000 | 200.00000 | |
| meat products: | 50.00000 | 200.00000 | |
| milk products: | 50.00000 | 200.00000 | |
| nut products: | 50.00000 | 200.00000 | |
| other grains: | 50.00000 | 200.00000 | |
| poultry: | 50.00000 | 200.00000 | |
| processed fruits: | 50.00000 | 200.00000 | |
| processed vegetables: | 50.00000 | 200.00000 | |
| reconstituted vegetables: | 50.00000 | 200.00000 | |
| seasonings / flavors: | 50000.00000 | 100000.00000 | |
| snack foods: | 50.00000 | 200.00000 | |
| soft candy: | 50.00000 | 200.00000 | |
| soups: | 50.00000 | 200.00000 | |
| sugar substitutes: | 50.00000 | 200.00000 | |
| sweet sauces: | 50.00000 | 200.00000 | |
| European Food Safety Authority (EFSA) reference(s): |
| Scientific opinion on the safety and efficacy of L-threonine produced by Escherichia coli (FERM BP-10942) for all animal species based on a dossier submitted by Ajinomoto Eurolysine SAS View page or View pdf |
| Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli for all animal species, based on a dossier submitted by HELM AG on behalf of Global Bio-Chem Technology View page or View pdf |
| Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli for all animal species, based on a dossier submitted by HELM AG on behalf of Star Lake Bioscience Co. View page or View pdf |
| Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli (FERM BP-11383) for all animal species, based on a dossier submitted by Ajinomoto Eurolysine S.A.S. View page or View pdf |
| Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli for all animal species based on a dossier submitted by HELM AG on behalf of Meihua Holdings Group Co. Ltd View page or View pdf |
| Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli strains NRRL B-30843, DSM 26131, KCCM11133P or DSM 25085 for all animal species based on a dossier submitted by AMAC EEIG View page or View pdf |
| Safety of L-threonine produced by fermentation using Escherichia coli CGMCC 3703, for all animal species based on a dossier submitted by GBT Europe GmbH View page or View pdf |
| Safety of L-threonine, technically pure, produced by fermentation with Escherichia coli CGMCC 7.58 for all animal species based on a dossier submitted by Feedway Europe NV View page or View pdf |
| Safety and efficacy of l-threonine produced by fermentation with Escherichia coli CGMCC 11473 for all animal species View page or View pdf |
| Safety and efficacy of l-threonine produced by fermentation with Corynebacterium glutamicum ����� for all animal species View page or View pdf |
| Safety and efficacy of l-threonine produced using Escherichia coliCGMCC 13325 as a feed additive for all animal species View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):72-19-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :6288 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| (2S,3R)-2-amino-3-hydroxybutanoic acid |
| Chemidplus:0000072195 |
| RTECS:XO8590000 for cas# 72-19-5 |
| (2S,3R)-2-amino-3-hydroxybutanoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 72-19-5 |
| Pubchem (cid): | 6288 |
| Pubchem (sid): | 134972477 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00188 |
| HMDB (The Human Metabolome Database): | HMDB00167 |
| FooDB: | FDB011999 |
| YMDB (Yeast Metabolome Database): | YMDB00214 |
| Export Tariff Code: | 2922.50.5000 |
| FDA Listing of Food Additive Status: | View |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| None Found |
| antistatic agents |
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| ajipure threonine | |
| (2S,3R)-2- | amino-3-hydroxybutanoic acid |
| (R-(R*,S*))-2- | amino-3-hydroxybutanoic acid |
| [R-(R*,S*)]-2- | amino-3-hydroxybutanoic acid |
| 2- | amino-3-hydroxybutanoic acid, (R-(R*,S*))- |
| (2S,3R)-2- | amino-3-hydroxybutyric acid |
| L-2- | amino-3-hydroxybutyric acid |
| butanoic acid, 2-amino-3-hydroxy-, (R-(R*,S*))- | |
| L- | threonin |
| (2S,3R)- | threonine |
| (2S,3R)-(-)- | threonine |
| (S)- | threonine |
| L- | threonine |
| L-(-)- | threonine |
