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1,1,1-trichloroethane

solvents
2D:
3D:
CAS Number: 71-55-6
ECHA EC Number: 200-756-3
FDA UNII: 113C650IR1
Category: solvents
IUPAC Name: 1,1,1-trichloroethane
InChI : InChI=1/C2H3Cl3/c1-2(3,4)5/h1H3
Std.InChI: InChI=1S/C2H3Cl3/c1-2(3,4)5/h1H3
InChIKey : UOCLXMDMGBRAIB-UHFFFAOYAP
Std.InChIKey: UOCLXMDMGBRAIB-UHFFFAOYSA-N
SMILES : ClC(Cl)(Cl)C
MDL: MFCD00000806
Molar Refractivity : 25.82 ± 0.3 cm3 (est)
Parachor : 222.1 ± 4.0 cm3 (est)
Index of Refraction : 1.451 ± 0.02 (est)
Surface Tension : 28.9 ± 3.0 dyne/cm (est)
Density : 1.393 ± 0.06 g/cm3 (est)
Polarizability : 10.23 ± 0.5 10-24cm3 (est)

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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FDA Mainterm (IAUFC):71-55-6 ; 1,1,1-TRICHLOROETHANE

Physical Properties:

Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.33800 @ 25.00 °C.
Melting Point: -30.10 °C. @ 760.00 mm Hg (est)
Boiling Point: 74.00 °C. @ 760.00 mm Hg
Vapor Pressure:124.000000 mmHg @ 25.00 °C. (est)
Vapor Density:4.63 ( Air = 1 )
Flash Point: 25.00 °F. TCC ( -3.70 °C. ) (est)
logP (o/w): 2.490
Soluble in:
water, 1290 mg/L @ 25 °C (exp)
water, 666.1 mg/L @ 25 °C (est)

Cosmetic Information:

CosIng:cosmetic data
Cosmetic Uses: solvents

Suppliers:

BOC Sciences
For experimental / research use only.
Trichloroethane
Shiva Chemicals and Pharmaceuticals
1-1-1 Trichloroethane
TCI AMERICA
For experimental / research use only.
1,1,1-Trichloroethane (1mg/mL in Methanol) [for Water Analysis]

Safety Information:

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-dog LD50 3100 mg/kg
LIVER: LIVER FUNCTION TESTS IMPAIRED
Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.

oral-dog LD50 750 mg/kg
Farm Chemicals Handbook. Vol. -, Pg. C310, 1991.

intravenous-dog LDLo 95 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 72, 1959.

oral-guinea pig LD50 9470 mg/kg
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.

oral-human TDLo 670 mg/kg
GASTROINTESTINAL: OTHER CHANGESGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"GASTROINTESTINAL: NAUSEA OR VOMITING
National Technical Information Service. Vol. PB257-185

intraperitoneal-mouse LD50 2568 mg/kg
Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 8, Pg. 371, 1966.

oral-mouse LD50 6000 mg/kg
CARDIAC: PULSE RATE
Gigiena Naselennykh Mest. Hygiene in Populated Places. Vol. 29, Pg. 45, 1990.

oral-rabbit LD50 5660 mg/kg
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.

intraperitoneal-rat LD50 3593 mg/kg
Environmental Research. Vol. 40, Pg. 411, 1986.

oral-rat LD50 9600 mg/kg
CARDIAC: PULSE RATE
Gigiena Naselennykh Mest. Hygiene in Populated Places. Vol. 29, Pg. 45, 1990.

Dermal Toxicity:
subcutaneous-mouse LD50 16000 mg/kg
BEHAVIORAL: ATAXIABEHAVIORAL: SLEEP
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958.

skin-rabbit LDLo 15800 mg/kg
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.

subcutaneous-rabbit LDLo 500 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 72, 1959.

Inhalation Toxicity:
inhalation-cat LC50 24400 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(8), Pg. 127, 1970.

inhalation-human TCLo 920 ppm/70M
SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYEBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.

inhalation-man TCLo 200 ppm/4H
BEHAVIORAL: IRRITABILITYBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives of Toxicology, Supplement. Vol. 5, Pg. 96, 1982.

inhalation-man TCLo 200 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
International Archives of Occupational and Environmental Health. Vol. 72, Pg. 485, 1999.

inhalation-man TCLo 350 ppm
BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTSBEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Work, Environment, Health. Vol. 10, Pg. 82, 1973.

inhalation-mouse LC50 3911 ppm/2H
BEHAVIORAL: EXCITEMENT
Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 13, Pg. 226, 1971.

inhalation-rat LC50 18000 ppm/4H
"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 28, 1972.

Safety in Use Information:

Category:
solvents
Recommendation for 1,1,1-trichloroethane usage levels up to:
not for fragrance use.
Recommendation for 1,1,1-trichloroethane flavor usage levels up to:
not for flavor use.

Safety References:

EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):71-55-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6278
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1,1,1-trichloroethane
Chemidplus:0000071556
EPA/NOAA CAMEO:hazardous materials
RTECS:71-55-6

References:

1,1,1-trichloroethane
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:71-55-6
Pubchem (cid):6278
Pubchem (sid):134972145

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C18246
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2903.19.5010
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•usepaopp pesticide code 081201; trade names: methyl chloroform.•1,1,1-trichloroethane is available commercially in the usa in technical and solvent grades, which differ only in amt of stabilizer added to prevent corrosion of metal parts.•chlorothene sm, industrial grade•aerothene tt, aerosol grade•industrial grade; aerosol grade; general solvent grade, 99.999% grade•stabilized grades contain 3-8% stabilizers such as nitromethane, n-methylpyrrole butylene oxide, 1,3-dioxolane, and secondary butyl alcohols.•stabilizing agents which may be present in small amounts include: glycol diesters, ketones, nitriles, dialkyl sulfoxides, dialkyl sulfides, dialkyl sulfites, tetraethyl lead, nitroaliphatic hydrocarbons, 2-methyl-3-butyn-2-ol, tert-butyl alcohol, 1,4-dioxane, dioxolane, sec-butyl alcohol, and monohydric acetylenic alcohols.

Potential Blenders and core components :

None Found

Potential Uses:

solvents

Occurrence (nature, food, other):

not found in nature

Synonyms:

chloroform, methyl-
chlorothane NU
ethana NU
ethane, 1,1,1-trichloro-
ethane, trichloro-
genklene LB
inhibisol
methyl chloroform
methylchloroform
methyltrichloromethane
tafclean
1,1,1-TCE
trichloro-1,1,1-ethane
1,1,1-trichloroethane
trichloromethylmethane

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