| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 67-68-5 |
| ECHA EC Number: | 200-664-3 |
| FDA UNII: | YOW8V9698H |
| Category: | multipurpose additives |
| IUPAC Name: | dimethyl sulfoxide |
| InChI : | InChI=1/C2H6OS/c1-4(2)3/h1-2H3 |
| Std.InChI: | InChI=1S/C2H6OS/c1-4(2)3/h1-2H3 |
| InChIKey : | IAZDPXIOMUYVGZ-UHFFFAOYAR |
| Std.InChIKey: | IAZDPXIOMUYVGZ-UHFFFAOYSA-N |
| SMILES : | CS(=O)C |
| MDL: | MFCD00002089 |
| Molar Refractivity : | 20.17 ± 0.3 cm3 (est) |
| Parachor : | 182.6 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.479 ± 0.02 (est) |
| Surface Tension : | 43.6 ± 3.0 dyne/cm (est) |
| Density : | 1.099 ± 0.06 g/cm3 (est) |
| Polarizability : | 7.99 ± 0.5 10-24cm3 (est) |
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.08700 to 1.09200 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 9.045 to 9.087 |
| Refractive Index: | 1.46900 to 1.48000 @ 20.00 °C. |
| Melting Point: | 17.00 to 19.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 189.00 to 190.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.610000 mmHg @ 25.00 °C. |
| Vapor Density: | 2.7 ( Air = 1 ) |
| Flash Point: | 183.00 °F. TCC ( 83.89 °C. ) |
| logP (o/w): | -1.350 |
| Soluble in: | |
| alcohol | |
| oil | |
| water, 1e+006 mg/L @ 25 °C (est) | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | not used anymore |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 23 - Do not breath vapour. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| gavage-rat LD50 [sex: M,F] 20000 mg/kg (Brown et al., 1963) gavage-mouse LD50 [sex: M,F] 20000 mg/kg (Brown et al., 1963) oral-mouse LD50 [sex: M,F] 21400 mg/kg (Willson et al., 1965) oral-rat LD50 [sex: M,F] 28300 mg/kg (Willson et al., 1965) oral-mouse LD50 [sex: M,F] 16500 mg/kg (Sommer & Tauberger, 1964) oral-rat LD50 [sex: M,F] 19700 mg/kg (Sommer & Tauberger, 1964) oral-mouse LD50 3100 mg/kg (Fishman et al., 1969) oral-rat LD50 14500 mg/kg (Fishman et al., 1969) oral-bird - wild LD50 100 mg/kg Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. intravenous-cat LDLo 200 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1571, 1978. oral-chicken LD50 12000 mg/kg Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963. intravenous-dog LD50 2500 mg/kg CARDIAC: OTHER CHANGESKIDNEY, URETER, AND BLADDER: HEMATURIAKIDNEY, URETER, AND BLADDER: OTHER CHANGES Cancer Chemotherapy Reports. Vol. 31, Pg. 7, 1963. oral-dog LD50 > 10000 mg/kg Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967. intraperitoneal-guinea pig LDLo > 5500 mg/kg Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963. oral-guinea pig LDLo > 11000 mg/kg Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 688, 1963. oral-mammal (species unspecified) LD50 21400 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974. intravenous-man TDLo 606 mg/kg LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 2, Pg. 1004, 1980. intraperitoneal-mouse LD50 2500 mg/kg Russian Pharmacology and Toxicology Vol. 35, Pg. 300, 1972. intravenous-mouse LD50 3100 mg/kg SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYESENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969. oral-mouse LD50 7920 mg/kg Chimica Therapeutica. Vol. 3, Pg. 10, 1968. unreported-mouse LD50 12000 mg/kg United States Patent Document. Vol. #4767763 intraperitoneal-rat LD50 8200 mg/kg Food and Chemical Toxicology. Vol. 22, Pg. 665, 1984. intravenous-rat LD50 5360 mg/kg BEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEA Toxicology and Applied Pharmacology. Vol. 7, Pg. 104, 1965. oral-rat LD50 14500 mg/kg SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYESENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE Toxicology and Applied Pharmacology. Vol. 15, Pg. 74, 1969. unreported-rat LD50 1300 mg/kg National Technical Information Service. Vol. AD-A159-418 | |
| Dermal Toxicity: | |
| skin-rat LD50 40000 mg/kg National Technical Information Service. Vol. AD-A159-418 subcutaneous-rat LD50 12000 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1050, 1964. subcutaneous-mouse LD50 14000 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)LUNGS, THORAX, OR RESPIRATION: OTHER CHANGESKIDNEY, URETER, AND BLADDER: HEMATURIA Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967. skin-mouse LD50 50000 mg/kg Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967. skin-rat LD50 40000 gm/kg Annals of the New York Academy of Sciences. Vol. 141, Pg. 96, 1967. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| multipurpose additives | |||
| Recommendation for dimethyl sulfoxide usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | ND (μg/capita/day) | ||
| Structure Class: | III | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 18 | |||
| Click here to view publication 18 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 0.10000 | 5.00000 | |
| beverages(nonalcoholic): | 0.10000 | 5.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | 0.10000 | 5.00000 | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 0.10000 | 5.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | 0.10000 | 5.00000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 0.10000 | 5.00000 | |
| milk products: | 0.10000 | 5.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | 100.00000 | 1000.00000 | |
| snack foods: | - | - | |
| soft candy: | 0.10000 | 5.00000 | |
| soups: | 0.10000 | 5.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | 0.10000 | 5.00000 | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 View page or View pdf |
| Flavouring Group Evaluation 74 (FGE.74)[1]: Consideration of Simple Aliphatic Sulphides and Thiols evaluated by JECFA (61st meeting) Structurally related to Aliphatic and Alicyclic Mono-, Di-, Tri-, and Polysulphides with or without Additional Oxygenated Functional Groups from Chemical Group 20 evaluated by EFSA in FGE.08 (2008) View page or View pdf |
| Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
| Flavouring Group Evaluation 91 (FGE.91): Consideration of simple aliphatic and aromatic sulphides and thiols evaluated by JECFA (53rd and 68th meetings) structurally related to aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups evaluated by EFSA in FGE.08Rev1 (2009) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
| Scientific Opinion on the safety and efficacy of aliphatic and aromatic mono- and di-thiols and mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups (chemical group 20) when used as flavourings for all animal species View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):67-68-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :679 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| methylsulfinylmethane |
| Chemidplus:0000067685 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:67-68-5 |
| methylsulfinylmethane | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 67-68-5 |
| Pubchem (cid): | 679 |
| Pubchem (sid): | 134970726 |
| Flavornet: | 67-68-5 |
| Pherobase: | View |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| UM BBD: | Search |
| KEGG (GenomeNet): | C11143 |
| HMDB (The Human Metabolome Database): | HMDB02151 |
| FooDB: | FDB000764 |
| Export Tariff Code: | 2930.90.9190 |
| MedlinePlusSupp: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| FAO: | Methylsulfinylmethane |
| Formulations/Preparations: •dimethyl sulfoxide is presently available as rimso-5, in a 50% aqueous solution.•u.s. - 50% [rimso-50; generic]; canada - 50% [rimso-50]. | |
| apple fruit Search PMC Picture | |
| beer Search PMC Picture | |
| cabbage raw cabbage Search Trop Picture | |
| cocoa Search Trop Picture | |
| coffee Search PMC Picture | |
| corn sweet corn Search PMC Picture | |
| cucumber Search Trop Picture | |
| malt Search PMC Picture | |
| milk Search PMC Picture | |
| onion Search Trop Picture | |
| oyster Search PMC Picture | |
| peppermint oil Search Trop Picture | |
| pork liver Search Picture | |
| raspberry red raspberry fruit Search Trop Picture | |
| rum Search PMC Picture | |
| shrimp cooked Search PMC Picture | |
| spearmint oil Search Trop Picture | |
| tea black tea Search Trop Picture | |
| tomato Search Trop Picture |
| demsodrox | |
| dermasorb | |
| dimethyl sulfoxide USP grade | |
| dimethyl sulphoxide | |
| dimethyl-sulfoxide | |
| dimethyli sulfoxidum | |
| dimethylsulfoniumolate | |
| dimethylsulfoxide | |
| DMSO | |
| dolicur | |
| dromisol | |
| hyadur | |
| methane, 1,1'-sulfinylbis- | |
| ( | methanesulfinyl)methane |
| methyl sulfinyl methane | |
| methyl sulfoxide | |
| ( | methylsulfinyl)methane |
| methylsulfinylmethane | |
| rimso 50 | |
| sclerosol | |
| somipront | |
| sulfinyl bis(methane) | |
| sulfinylbismethane | |
| sulfinyldimethane | |
| sulfoxide, dimethyl | |
| sulphoxide, dimethyl | |
| syntexan | |
| topsym |
