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3D: | |
CAS Number: | 60-12-8 |
ECHA EC Number: | 200-456-2 |
FDA UNII: | ML9LGA7468 |
CoE Number: | 68 |
Category: | flavor and fragrance agents |
IUPAC Name: | phenethyl alcohol |
InChI : | InChI=1/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2 |
Std.InChI: | InChI=1S/C8H10O/c9-7-6-8-4-2-1-3-5-8/h1-5,9H,6-7H2 |
InChIKey : | WRMNZCZEMHIOCP-UHFFFAOYAN |
Std.InChIKey: | WRMNZCZEMHIOCP-UHFFFAOYSA-N |
SMILES : | C1=CC=C(C=C1)CCO |
MDL: | MFCD00002886 |
Molar Refractivity : | 37.33 ± 0.3 cm3 (est) |
Parachor : | 300.6 ± 4.0 cm3 (est) |
Index of Refraction : | 1.535 ± 0.02 (est) |
Surface Tension : | 39.6 ± 3.0 dyne/cm (est) |
Density : | 1.020 ± 0.06 g/cm3 (est) |
Polarizability : | 14.80 ± 0.5 10-24cm3 (est) |
Fragrance Demo Formulas |
Google Scholar: | Search |
Google Books: | Search |
Google Scholar: with word "volatile" | Search |
Google Scholar: with word "flavor" | Search |
Google Scholar: with word "odor" | Search |
Perfumer and Flavorist: | Search |
Google Patents: | Search |
US Patents: | Search |
EU Patents: | Search |
Pubchem Patents: | Search |
PubMed: | Search |
NCBI: | Search |
JECFA Food Flavoring: | 987 phenethyl alcohol |
DG SANTE Food Flavourings: | 02.019 2-phenylethanol |
FEMA Number: | 2858 phenethyl alcohol |
FDA: | No longer provide for the use of these seven synthetic flavoring substances |
FDA Mainterm (SATF): | 60-12-8 ; PHENETHYL ALCOHOL |
FDA Regulation: | |
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. |
Appearance: | colorless clear oily liquid (est) |
Assay: | 98.00 to 100.00 |
Halogens: | Chlorine free |
Food Chemicals Codex Listed: | Yes |
Specific Gravity: | 1.01500 to 1.02300 @ 25.00 °C. |
Pounds per Gallon - (est).: | 8.446 to 8.512 |
Specific Gravity: | 1.01600 to 1.02400 @ 20.00 °C. |
Pounds per Gallon - est.: | 8.464 to 8.531 |
Refractive Index: | 1.53000 to 1.53400 @ 20.00 °C. |
Melting Point: | -27.00 to -25.80 °C. @ 760.00 mm Hg |
Boiling Point: | 219.00 to 221.00 °C. @ 760.00 mm Hg |
Boiling Point: | 136.00 to 137.00 °C. @ 50.00 mm Hg |
PH Number: | 7.00 |
Vapor Pressure: | 0.086800 mmHg @ 25.00 °C. |
Vapor Density: | 4.21 ( Air = 1 ) |
Flash Point: | 216.00 °F. TCC ( 102.00 °C. ) |
logP (o/w): | 1.360 |
Shelf Life: | 24.00 month(s) or longer if stored properly. |
Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Soluble in: | |
alcohol | |
dipropylene glycol | |
fixed oils | |
kerosene | |
mineral oil, slightly | |
propylene glycol | |
water, 2.199e+004 mg/L @ 25 °C (est) | |
water, 2.22E+04 mg/L @ 25 °C (exp) | |
Insoluble in: | |
paraffin oil | |
Stability: | |
alcoholic lotion | |
antiperspirant | |
bleach | |
deo stick | |
detergent perborate | |
fabric softener | |
hair spray | |
hard surface cleaner | |
liquid detergent | |
non-discoloring in most media | |
shampoo |
CosIng: | cosmetic data |
Cosmetic Uses: | fragrance |
Preferred SDS: View | |
European information : | |
Most important hazard(s): | |
Xn - Harmful. | |
R 21/22 - Harmful in contact with skin and if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
Hazards identification | |
Classification of the substance or mixture | |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
Acute toxicity, Oral (Category 4), H302 Eye irritation (Category 2A), H319 | |
GHS Label elements, including precautionary statements | |
Pictogram | ![]() |
Signal word | Warning |
Hazard statement(s) | |
H302 - Harmful if swallowed H319 - Causes serious eye irritation | |
Precautionary statement(s) | |
P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P330 - Rinse mouth. P337 + P313 - IF eye irritation persists: Get medical advice/attention. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
Human Experience: | |
100 %: no skin irritation. 8 % solution: non-sensitising. | |
Oral/Parenteral Toxicity: | |
oral-mouse LD50 800 - 1500 mg/kg (Fassett, 1963) oral-guinea pig LD50 400 - 800 mg/kg (Fassett, 1963) oral-rat LD50 1800 mg/kg (Rumyantsev et al., 1987) oral-rat LD50 [sex: M] 1900 mg/kg 2 Test substance administered as 5% musk ambrette in phenethyl alcohol. (Moreno, 1982e) gavage-rat LD50 [sex: M,F] 1790 mg/kg (Jenner et al., 1964) oral-rat LD50 2234 mg/kg 1 Value based on specific gravity = 1.02. (Zeller & Hoffmann, 1974) oral-rat LD50 [sex: M] 2100 mg/kg 3 Test substance administered as 20% musk ambrette in phenethyl alcohol. (Moreno, 1982f) gavage-rat LD50 [sex: M,F] 2540 mg/kg (Zaitsev & Rakhmanina, 1974) gavage-mouse LD50 [sex: M,F] 2540 mg/kg (Zaitsev & Rakhmanina, 1974) gavage-guinea pig LD50 [sex: M,F] 2540 mg/kg (Zaitsev & Rakhmanina, 1974) gavage-rat LD50 [sex: M,F] 1609 mg/kg (Mallory et al., 1982a) oral-rat LD50 [sex: M,F] 2509 mg/kg 1 Value based on specific gravity = 1.02. (Carpenter et al., 1974) gavage-rat LD50 [sex: F] 3100 mg/kg 4 Test substance administered as beta-phenethyl alcohol. (Grote & Woods, 1955) intraperitoneal-guinea pig LD50 200 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4642, 1982. oral-guinea pig LD50 2540 mg/kg Voprosy Pitaniya. Problems of Nutrition. Vol. 33(5), Pg. 48, 1974. oral-mouse LD50 2540 mg/kg Voprosy Pitaniya. Problems of Nutrition. Vol. 33(5), Pg. 48, 1974. oral-rabbit LDLo 2000 mg/kg Journal of Economic Entomology. Vol. 48, Pg. 139, 1955. oral-rat LD50 1790 mg/kg GASTROINTESTINAL: GASTRITISBEHAVIORAL: COMA Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. | |
Dermal Toxicity: | |
skin-guinea pig LD50 > 5 ml/kg Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. subcutaneous-mouse LDLo 1640 mg/kg BEHAVIORAL: COMABEHAVIORAL: ATAXIABEHAVIORAL: GENERAL ANESTHETIC Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 211, 1920. skin-rabbit LD50 790 uL/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. | |
Inhalation Toxicity: | |
inhalation-rat LC50 > 500 mg/m3 BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BLOOD: NORMOCYTIC ANEMIA Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(10), Pg. 83, 1987. |
Category: | |||
flavor and fragrance agents | |||
RIFM Fragrance Material Safety Assessment: Search | |||
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
Recommendation for phenethyl alcohol usage levels up to: | |||
40.0000 % in the fragrance concentrate. | |||
Maximised Survey-derived Daily Intakes (MSDI-EU): | 1200.00 (μg/capita/day) | ||
Maximised Survey-derived Daily Intakes (MSDI-USA): | 330.00 (μg/capita/day) | ||
Structure Class: | I | ||
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
publication number: 3. Update in publication number(s): 29 | |||
Click here to view publication 3 | |||
average usual ppm | average maximum ppm | ||
baked goods: | 27.00000 | 33.00000 | |
beverages(nonalcoholic): | 13.00000 | 18.00000 | |
beverages(alcoholic): | 250.00000 | 250.00000 | |
breakfast cereal: | - | - | |
cheese: | - | - | |
chewing gum: | 25.00000 | 80.00000 | |
condiments / relishes: | - | - | |
confectionery froastings: | - | - | |
egg products: | - | - | |
fats / oils: | 0.05000 | 0.10000 | |
fish products: | - | - | |
frozen dairy: | 19.00000 | 23.00000 | |
fruit ices: | - | - | |
gelatins / puddings: | 6.00000 | 10.00000 | |
granulated sugar: | - | - | |
gravies: | - | - | |
hard candy: | 2.00000 | 12.00000 | |
imitation dairy: | - | - | |
instant coffee / tea: | - | - | |
jams / jellies: | - | - | |
meat products: | - | - | |
milk products: | - | - | |
nut products: | - | - | |
other grains: | - | - | |
poultry: | - | - | |
processed fruits: | - | - | |
processed vegetables: | - | - | |
reconstituted vegetables: | - | - | |
seasonings / flavors: | - | - | |
snack foods: | - | - | |
soft candy: | 26.00000 | 30.00000 | |
soups: | - | - | |
sugar substitutes: | - | - | |
sweet sauces: | - | - |
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to: Flavouring Group Evaluation 14 (FGE.14): Phenethyl alcohol, aldehyde, esters, and related phenylacetic acid esters from chemical group 15 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 55 (FGE.55): Consideration of phenyl-substituted aliphatic alcohols and related aldehydes and esters evaluated by JECFA (63rd meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and aryl-substituted saturated and unsaturated primary alcohol/aldehyde/acid/ester derivatives evaluated by EFSA in FGE.15 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 53 (FGE.53): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) structurally related to phenethyl alcohol, aldehyde, esters and related phenylacetic acid esters evaluated by EFSA in FGE.14 (2005) and one phenoxyethyl ester evaluated in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 14, Revision 1 (FGE.14Rev1): Phenethyl alcohol, aldehyde, acetals, carboxylic acid and related esters from chemical group 15 and 22 [1] - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 53, Revision 1 (FGE.53Rev1): Consideration of phenethyl alcohol, aldehyde, acid and related acetals and esters evaluated by JECFA (59th meeting) FGE.23Rev1 (2008) View page or View pdf |
Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species View page or View pdf |
EPI System: View |
ClinicalTrials.gov:search |
Daily Med:search |
NIOSH International Chemical Safety Cards:search |
AIDS Citations:Search |
Cancer Citations:Search |
Toxicology Citations:Search |
EPA GENetic TOXicology:Search |
EPA Substance Registry Services (TSCA):60-12-8 |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
Laboratory Chemical Safety Summary :6054 |
National Institute of Allergy and Infectious Diseases:Data |
WISER:UN 2810 |
WGK Germany:1 |
2-phenylethanol |
Chemidplus:0000060128 |
RTECS:60-12-8 |
2-phenylethanol | |
NIST Chemistry WebBook: | Search Inchi |
Canada Domestic Sub. List: | 60-12-8 |
Pubchem (cid): | 6054 |
Pubchem (sid): | 134972772 |
Flavornet: | 60-12-8 |
Pherobase: | View |
(IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
Videos: | The Periodic Table of Videos |
tgsc: | Atomic Weights use for this web site |
(IUPAC): | Periodic Table of the Elements |
FDA Substances Added to Food (formerly EAFUS): | View |
CHEBI: | View |
CHEMBL: | View |
Golm Metabolome Database: | Search |
Metabolomics Database: | Search |
KEGG (GenomeNet): | C05853 |
HMDB (The Human Metabolome Database): | HMDB33944 |
FooDB: | FDB012152 |
YMDB (Yeast Metabolome Database): | YMDB01072 |
Export Tariff Code: | 2901.29.5000 |
Typical G.C. | |
VCF-Online: | VCF Volatile Compounds in Food |
ChemSpider: | View |
Wikipedia: | View |
aleppo pine Search PMC Picture | |
almond flower Search Trop Picture | |
apple fruit Search PMC Picture | |
apple kogyoku apple Search PMC Picture | |
apricot fruit Search Trop Picture | |
banana fruit Search Trop Picture | |
basil plant Search Trop Picture | |
basswood flower Search Trop Picture | |
beer Search PMC Picture | |
bilberry fruit juice Search Trop Picture | |
blueberry fruit Search Trop Picture | |
caninha Search PMC Picture | |
carnation Search Trop Picture | |
cassava Search Trop Picture | |
cassia plant Search Trop Picture | |
chamchwi korean chamchwi Search Trop Picture | |
champaca absolute (michelia alba dc.) @ 6.38% Data GC Search Trop Picture | |
champaca absolute @ 25.00% Data GC Search Trop Picture | |
champaca concrete @ 2.58% Data GC Search Trop Picture | |
champaca concrete @ 30.00% Data GC Search Trop Picture | |
cheese bleu cheese Search PMC Picture | |
cheese swiss mountain cheese Search PMC Picture | |
cinnamon ceylon cinnamon bark Search Trop Picture | |
cinnamon ceylon cinnamon leaf Search Trop Picture | |
cinnamon ceylon cinnamon root bark Search Trop Picture | |
corn silk Search Trop Picture | |
elder black elder flower oil Search Trop Picture | |
eschweilera coriacea (a. p. dc.) mori flower oil brazil @ 6.80% Data GC Search Trop Picture | |
filbert Search Trop Picture | |
genet absolute @ 0.50% Data GC Search Trop Picture | |
geranium leaf oil india @ 0.13% Data GC Search Trop Picture | |
geranium petiole oil india @ 0.10% Data GC Search Trop Picture | |
geranium stem oil india @ 0.26% Data GC Search Trop Picture | |
hyacinth Search Trop Picture | |
hyacinthus orientalis absolute @ 8.96-16.39% Data GC Search Trop Picture | |
hyssop plant Search Trop Picture | |
jasmin PbMd Search PMC Picture | |
jasmin sambac absolute egypt @ 2.15% Data GC Search Trop Picture | |
ketaki flower oil india @ 4.50% Data GC Search Trop Picture | |
kewda oil @ 0.05-0.13% Data GC Search Trop Picture | |
kiwi fruit flower Search Trop Picture | |
lecythis usitata miers. var. paraensis (ducke) r. kunth. flower oil brazil @ 40.80% Data GC Search Trop Picture | |
lemon Search Trop Picture | |
lemon balm tissue culture Search Trop Picture | |
lily Search PMC Picture | |
lime Search Trop Picture | |
mandarin Search Trop Picture | |
michelia alba flower absolute @ 0.39% Data GC Search Trop Picture | |
michelia champaca Search Trop Picture | |
michelia champaca flower absolute @ 3.15% Data GC Search Trop Picture | |
mushrooms Search PMC Picture | |
mustard white mustard Search Trop Picture | |
narcissus absolute @ 0.57% Data GC Search Trop Picture | |
neroli Search PMC Picture | |
neroli oil CO2 extract @ 0.64% Data GC Search Trop Picture | |
orange fruit Search Trop Picture | |
orange fruit juice Search Trop Picture | |
orangeflower absolute morocco @ 0.0-2.1% Data GC Search Trop Picture | |
orangeflower water absolute @ 0.9-3.9% Data GC Search Trop Picture | |
pandamus odoratissimus congo Search Trop Picture | |
parsley Search Trop Picture | |
parsley fruit oil Search Trop Picture | |
parsley plant Search Trop Picture | |
parsley seed oil Search Trop Picture | |
peach fruit Search Trop Picture | |
pear fruit Search Trop Picture | |
peppermint leaf Search Trop Picture | |
petitgrain mandarin oil @ 0.03% Data GC Search Trop |
benzene ethanol | |
benzeneethanol | |
benzyl carbinol | |
benzyl methanol | |
2- | hydroxyethyl benzene |
(2- | hydroxyethyl)benzene |
2- | hydroxyethylbenzene |
b- | hydroxyethylbenzene |
mellol | |
beta- | p.e.a. |
b- | phenethanol |
2- | phenethyl alcohol |
phenethyl alcohol nat. | |
phenethyl alcohol natural | |
phenethyl alcohol turkey, natural isolated constituent | |
phenethylalcohol | |
phenethylol | |
2- | phenyl ethan-1-ol |
phenyl ethanol | |
2- | phenyl ethanol |
beta- | phenyl ethanol |
phenyl ethyl alcohol | |
2- | phenyl ethyl alcohol |
beta- | phenyl ethyl alcohol |
nat. | phenyl ethyl alcohol |
phenyl ethyl alcohol extra | |
phenyl ethyl alcohol FCC | |
phenyl ethyl alcohol natural | |
phenyl ethyl alcohol USP 24 | |
1- | phenyl-2-ethanol |
phenylethanol | |
2- | phenylethanol |
b- | phenylethanol |
phenylethanol nat | |
phenylethyl alcohol | |
b- | phenylethyl alcohol |
phenylethyl alcohol (2-phenyl-1-ethanol) | |
phenylethyl alcohol FCC | |
phenylethyl alcohol USP/NF | |
viguard CPEA |