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trimyristin

cosmetic agents
2D:
3D:
CAS Number: 555-45-3
ECHA EC Number: 209-099-7
FDA UNII: 18L31PSR28
Category: cosmetic agents
IUPAC Name: trimyristin
InChI : InChI=1/C45H86O6/c1-4-7-10-13-16-19-22-25-28-31-34-37-43(46)49-40-42(51-45(48)39-36-33-30-27-24-21-18-15-12-9-6-3)41-50-44(47)38-35-32-29-26-23-20-17-14-11-8-5-2/h42H,4-41H2,1-3H3
Std.InChI: InChI=1S/C45H86O6/c1-4-7-10-13-16-19-22-25-28-31-34-37-43(46)49-40-42(51-45(48)39-36-33-30-27-24-21-18-15-12-9-6-3)41-50-44(47)38-35-32-29-26-23-20-17-14-11-8-5-2/h42H,4-41H2,1-3H3
InChIKey : DUXYWXYOBMKGIN-UHFFFAOYAC
Std.InChIKey: DUXYWXYOBMKGIN-UHFFFAOYSA-N
SMILES : CCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC
MDL: MFCD00036229
Molar Refractivity : 215.81 ± 0.3 cm3 (est)
Parachor : 18.94.0 ± 4.0 cm3 (est)
Index of Refraction : 1.463 ± 0.02 (est)
Surface Tension : 34.3 ± 3.0 dyne/cm (est)
Density : 0.924 ± 0.06 g/cm3 (est)
Polarizability : 85.55 ± 0.5 10-24cm3 (est)

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search

Physical Properties:

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 56.50 °C. @ 760.00 mm Hg
Boiling Point: 311.00 °C. @ 760.00 mm Hg
Boiling Point: 703.00 to 704.00 °C. @ 760.00 mm Hg (est)
Flash Point: 520.00 °F. TCC ( 270.90 °C. ) (est)
logP (o/w): 18.558 (est)
Soluble in:
water, 9.596e-015 mg/L @ 25 °C (est)

Cosmetic Information:

CosIng:cosmetic data
Cosmetic Uses: refatting agents
skin conditioning
skin conditioning - emollient
solvents
viscosity controlling agents

Suppliers:

Alfa Biotechnology
For experimental / research use only.
Trimyristin 98%
BOC Sciences
For experimental / research use only.
TRIMYRISTIN >95.0%(GC)
ExtraSynthese
For experimental / research use only.
Trimyristin
Rose Office
Trimyristin, Nutmeg Extract, Pulverised Philippines
Rose Office
Trimyristin, Nutmeg extract, in block Philippines
Sigma-Aldrich: Sigma
For experimental / research use only.
Glyceryl trimyristate ≥99%
TCI AMERICA
For experimental / research use only.
Trimyristin >95.0%(GC)

Safety Information:

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
cosmetic agents
Recommendation for trimyristin usage levels up to:
not for fragrance use.
Recommendation for trimyristin flavor usage levels up to:
not for flavor use.

Safety References:

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):555-45-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11148
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
2,3-di(tetradecanoyloxy)propyl tetradecanoate
Chemidplus:0000555453

References:

2,3-di(tetradecanoyloxy)propyl tetradecanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):11148
Pubchem (sid):134976522

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
HMDB (The Human Metabolome Database):HMDB42061
FooDB:FDB002889
YMDB (Yeast Metabolome Database):YMDB00825
Export Tariff Code:2917.19.7050
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

Potential Blenders and core components :

None Found

Potential Uses:

emollients
solvents
viscosity controlling agents

Occurrence (nature, food, other):

nutmeg seed
Search Trop Picture

Synonyms:

2,3-di(tetradecanoyloxy)propyl tetradecanoate
glycerin trimyristate
glycerol trimyristate
glycerol trimyristirate
glyceryl trimyristate
myristic acid triglyceride
myristin, tri- (8CI)
1,2,3-propane triol tritetradecanoate
propane-1,2,3-triyl tritetradecanoate
1,2,3-propanetriol tritetradecanoate
1,2,3-propanetriyl tritetradecanoate
tetradecanoic acid, 1,2,3-propanetriyl ester
trimyristoylglycerol
1,2,3-tritetradecanoylglycerol

Articles:

PubMed:Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate.
PubMed:Development of a new approach to investigating the drug transfer from colloidal carrier systems applying lipid nanosuspension-containing alginate microbeads as acceptor.
PubMed:Liquid crystalline phase formation in suspensions of solid trimyristin nanoparticles.
PubMed:Comparative study on the suitability of two techniques for measuring the transfer of lipophilic drug models from lipid nanoparticles to lipophilic acceptors.
PubMed:Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection--preparation, characterisation and in vivo evaluation.
PubMed:Lipid nanoparticles: drug localization is substance-specific and achievable load depends on the size and physical state of the particles.
PubMed:Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.
PubMed:Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation.
PubMed:Solid lipid particles for oral delivery of peptide and protein drugs II--the digestion of trilaurin protects desmopressin from proteolytic degradation.
PubMed:Solid lipid nanoparticle formulations of docetaxel prepared with high melting point triglycerides: in vitro and in vivo evaluation.
PubMed:Evaluation of Shirasu Porous Glass (SPG) membrane emulsification for the preparation of colloidal lipid drug carrier dispersions.
PubMed:Solid lipid particles for oral delivery of peptide and protein drugs I--elucidating the release mechanism of lysozyme during lipolysis.
PubMed:Influence of membrane structure on the preparation of colloidal lipid dispersions by premix membrane emulsification.
PubMed:Analytical contribution of NAD 2D-NMR spectroscopy in polypeptide mesophases to the investigation of triglycerides.
PubMed:Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids.
PubMed:Extraction of betulin, trimyristin, eugenol and carnosic acid using water-organic solvent mixtures.
PubMed:Cellular delivery of cationic lipid nanoparticle-based SMAD3 antisense oligonucleotides for the inhibition of collagen production in keloid fibroblasts.
PubMed:Preparation of nanoemulsions and solid lipid nanoparticles by premix membrane emulsification.
PubMed:Spray congealed lipid microparticles with high protein loading: preparation and solid state characterisation.
PubMed:Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles.
PubMed:Preparation and characterization of nitrendipine solid lipid nanoparticles.
PubMed:The physical state of lipid nanoparticles influences their effect on in vitro cell viability.
PubMed:Pharmacokinetics and biodistribution of paclitaxel loaded in pegylated solid lipid nanoparticles after intravenous administration.
PubMed:Formulation and in vitro characterization of domperidone loaded solid lipid nanoparticles and nanostructured lipid carriers.
PubMed:Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the Nervous Tissue of Snail Lymnaea acuminata.
PubMed:Short chain saturated fatty acids decrease circulating cholesterol and increase tissue PUFA content in the rat.
PubMed:Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairment.
PubMed:Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment.
PubMed:Possible fungistatic implications of betulin presence in betulaceae plants and their hymenochaetaceae parasitic fungi.
PubMed:Nondestructive rheological measurement of aqueous dispersions of solid lipid nanoparticles: effects of lipid types and concentrations on dispersion consistency.
PubMed:Flow cytometry as a new approach to investigate drug transfer between lipid particles.
PubMed:Improving oral absorption of Salmon calcitonin by trimyristin lipid nanoparticles.
PubMed:Fatty acid selectivity of lipases during acidolysis reaction between oleic acid and monoacid triacylglycerols.
PubMed:Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the alpha-modification.
PubMed:Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics.
PubMed:Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychrotrophic bacterium, Psychrobacter sp 7195.
PubMed:In vivo evaluation of lipid nanocapsules as a promising colloidal carrier for paclitaxel.
PubMed:Lipids of human meibum: mass-spectrometric analysis and structural elucidation.
PubMed:Tracking single lipase molecules on a trimyristin substrate surface using quantum dots.
PubMed:Isolation of lipase producing Bacillus sp. from olive mill wastewater and improving its enzyme activity.
PubMed:Confocal microscopy for the elucidation of mass transport mechanisms involved in protein release from lipid-based matrices.
PubMed:Mobility of Thermomyces lanuginosus lipase on a trimyristin substrate surface.
PubMed:Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles.
PubMed:Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration.
PubMed:Antibacterial principles from Myristica fragrans seeds.
PubMed:Isostatic ultra-high-pressure effects on supercooled melts in colloidal triglyceride dispersions.
PubMed:Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles.
PubMed:Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
PubMed:Raman spectroscopy investigation of various saturated monoacid triglycerides.
PubMed:Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides.
PubMed:Investigation on the flow behavior of dispersions of solid triglyceride nanoparticles.
PubMed:Enzymatic synthesis of medium-chain triglycerides in a solvent-free system.
PubMed:Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages-impact of phagocytosis on viability and cytokine production.
PubMed:Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.
PubMed:Monolithic triglyceride matrices: a controlled-release system for proteins.
PubMed:Monolithic glyceryl trimyristate matrices for parenteral drug release applications.
PubMed:A supercritical fluid-based coating technology. 3: preparation and characterization of bovine serum albumin particles coated with lipids.
PubMed:A supercritical fluid-based coating technology. 2: solubility considerations.
PubMed:A supercritical fluid-based coating technology 1: process considerations.
PubMed:Microencapsulation of protein particles within lipids using a novel supercritical fluid process.
PubMed:Rapid thermogravimetric measurements of boiling points and vapor pressure of saturated medium- and long-chain triglycerides.
PubMed:Process development for production of medium chain triglycerides using immobilized lipase in a solvent-free system.
PubMed:Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity.
PubMed:Anxiogenic activity of Myristica fragrans seeds.
PubMed:Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate.
PubMed:Structure of beta-trimyristin and beta-tristearin from high-resolution X-ray powder diffraction data.
PubMed:Interactive effects of dietary cholesterol and different saturated fatty acids on lipoprotein metabolism in the hamster.
PubMed:[Comparative study on nutmeg, mace and their processed products].
PubMed:Structure of mono-acid even-numbered beta-triacylglycerols.
PubMed:Staphylococcus haemolyticus lipase: biochemical properties, substrate specificity and gene cloning.
PubMed:Effect of synthetic triglycerides of myristic, palmitic, and stearic acid on serum lipoprotein metabolism.
PubMed:The effect of different dietary fatty acids on lipoprotein metabolism: concentration-dependent effects of diets enriched in oleic, myristic, palmitic and stearic acids.
PubMed:Genetic determinants of plasma lipoprotein levels and their dietary response.
PubMed:Hepatic microsomal triglyceride transfer protein messenger RNA concentrations are increased by dietary cholesterol in hamsters.
PubMed:Dietary myristic acid alters acylated proteins in activated murine macrophages.
PubMed:Interactive effects of dietary cholesterol and saturated fat on low density lipoprotein cholesterol.
PubMed:Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats. Comparison of trimyristin, tripalmitin, tristearin and triolein.
PubMed:Regulation of hamster hepatic microsomal triglyceride transfer protein mRNA levels by dietary fats.
PubMed:[Identification of nutmeg by thin-layer chromatography and its introduction to Japanese standards for non-pharmacopoeial crude drugs].
PubMed:The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat.
PubMed:Characterization of lipases from the lipid bodies and microsomal membranes of erucic acid-free oilseed-rape (Brassica napus) cotyledons.
PubMed:Hepatic triacylglycerol lipase in circulating blood of normal and tumor-bearing mice and its hydrolysis of very-low-density lipoprotein and synthetic acylglycerols.
PubMed:Effects of dietary triglycerides on serum and liver lipids and sterol excretion of rats.
PubMed:Dietary fat dependence of intestinal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in rats.
PubMed:Effect of dietary triglycerides on lymphocyte transformation in rats.
PubMed:[Effect of short- or medium-chain fatty acids on cholesterol dynamics in the rat].
PubMed:The pharmacological effects of the ligroin extract of nutmeg (Myristica fragrans).
PubMed:Partial purification and characterization of lipase (EC 3.1.1.3) from Propionibacterium acnes.
PubMed:[Isolation and characteristics of Penicillium roqueforti lipases].
PubMed:Effects of diets of homogeneous saturated triglycerides on cholesterol balance in rats.
PubMed:Dietary fat-dependent changes in hepatic cholesterogenesis and the activity of 3-hydroxy-3-methylglutaryl-CoA reductase in fasted-refed rats.
PubMed:A sensitive bioassay for lipase using bacterial bioluminescence.
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