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cetyl palmitate

emollients, skin conditioning
2D:
3D:
CAS Number: 540-10-3
ECHA EC Number: 208-736-6
FDA UNII: 5ZA2S6B08X
Category: emollients, skin conditioning
IUPAC Name: cetyl palmitate
InChI : InChI=1/C32H64O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-34-32(33)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-31H2,1-2H3
Std.InChI: InChI=1S/C32H64O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-34-32(33)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-31H2,1-2H3
InChIKey : PXDJXZJSCPSGGI-UHFFFAOYAT
Std.InChIKey: PXDJXZJSCPSGGI-UHFFFAOYSA-N
SMILES : CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC
MDL: MFCD00053739
Molar Refractivity : 152.07 ± 0.3 cm3 (est)
Parachor : 1329.9 ± 4.0 cm3 (est)
Index of Refraction : 1.455 ± 0.02 (est)
Surface Tension : 31.7 ± 3.0 dyne/cm (est)
Density : 0.858 ± 0.06 g/cm3 (est)
Polarizability : 60.28 ± 0.5 10-24cm3 (est)

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:Search
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Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search

Physical Properties:

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 53.00 to 54.00 °C. @ 760.00 mm Hg
Boiling Point: 533.00 to 535.00 °C. @ 760.00 mm Hg
Flash Point: 518.00 °F. TCC ( 269.80 °C. ) (est)
logP (o/w): 15.051 (est)
Soluble in:
water, 3.134e-010 mg/L @ 25 °C (est)

Cosmetic Information:

CosIng:cosmetic data
Cosmetic Uses: fragrance
skin conditioning
skin conditioning - emollient

Suppliers:

Alzo International
Dermowax CP
Alzo International
Waxenol 810
American International Chemical, LLC.
Cetyl Palmitate
BOC Sciences
For experimental / research use only.
Cetyl Palmitate
Odor: characteristic
Use: Cetyl Palmitate, as a wax ester of palmitic acid, is used in cosmetic and personal care products.
Chemical-navi - Nikkol
NIKKOL N-SPV
Odor: characteristic
Use: Glosser and thickener for creams; plant-derived.
Croda
Crodamol™ CP
Odor: bland
Use: Dry emollient. Improves emulsion texture and stability and gives structure to cosmetic sticks. Used in skin and hair applications.
ECSA Chemicals
CETYL PALMITATE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
H. Erhard Wagner
(Cetylpalmitate)
HallStar
HALLSTAR® 653
Odor: characteristic
Use: HallStar 653 is a solid waxy ester made from the reaction of cetyl alcohol with palmitic acid. It is an emollient and emollient thickener in emulsions, a base or stiffener for stick products, and a substitute for Spermaceti wax.
HallStar
OLIWAX® LC
Odor: characteristic
Use: This HallStar Italia stabilizing agent and liquid crystal promoter is able to reorganize the emulsion structure on a microscopic level and is recommended in innovative and sophisticated cosmetic products. It can be easily used either in emulsions (in water or oil phase) or anhydrous systems, to which it provides a unique after-feel due to the high water content of the liquid crystalline structure formed in contact with the skin. It is a waxy solid in flake form at 20°C (melting point 45 - 55°C) and is validated by Ecocert. The recommended use levels are 3 - 4% in sunscreen emulsions as an SPF booster, 2 - 4% in O/W and W/O emulsions as a liquid crytstal promoter, 1 - 5% in make-up products as a structuring agent, 1 - 3% in W/O and O/W emulsions as a hydrating and moisturizing agent, and 1 - 2% in sunscreens as a viscosity stabilizer.
Kraft Chemical
Cetyl Palmitate
Mohini Organics
MONECOL® - PC
Odor: characteristic
Use: MONECOL® - PC is used for the Emollient effects in the Cosmetic Creams as well as in Antiseptic Creams. It is also termed as Spermaceti Wax.
Mohini Organics
MONECOL® - SCS
Odor: characteristic
Use: MONECOL® - SCS is used for the Emollient effect in Cosmetics and Internal Lubricant in Plastics.
Mosselman
Cetyl Palmitate
Penta International
CETYL PALMITATE NF GRADE
Penta International
CETYL PALMITATE
Sigma-Aldrich: Sigma
For experimental / research use only.
Palmityl palmitate ≥99%
Strahl & Pitsch
Cetyl Palmitate
SysKem Chemie
Cetyl Palmitate
TCI AMERICA
For experimental / research use only.
hexadecyl palmitate >95.0%(GC)

Safety Information:

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
emollients, skin conditioning
Recommendation for cetyl palmitate usage levels up to:
not for fragrance use.
Recommendation for cetyl palmitate flavor usage levels up to:
not for flavor use.

Safety References:

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):540-10-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10889
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
hexadecyl hexadecanoate
Chemidplus:0000540103
RTECS:RT4750000 for cas# 540-10-3

References:

hexadecyl hexadecanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:540-10-3
Pubchem (cid):10889
Pubchem (sid):134978807

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C13821
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2915.70.0050
ChemSpider:View
Wikipedia:View

Potential Blenders and core components :

None Found

Potential Uses:

emollients

Occurrence (nature, food, other):

not found in nature

Synonyms:

cetylpalmitate
crodamol CP
dermowax CP
hallstar 653
hexadecanoic acid hexadecyl ester
hexadecanoic acid, hexadecyl ester
hexadecyl hexadecanoate
1-hexadecyl hexadecanoate
N-hexadecyl hexadecanoate
hexadecyl palmitate
monecol - PC
monecol - SCS
nikkol N-SPV
oliwax LC
palmitic acid cetyl ester
palmitic acid hexadecyl ester
palmitic acid palmityl ester
palmitic acid, hexadecyl ester
palmityl palmitate
standamul 1616
waxenol 810

Articles:

PubMed:Formulation of solid lipid nanoparticles (SLN): The value of different alkyl polyglucoside surfactants.
PubMed:Idebenone loaded solid lipid nanoparticles: calorimetric studies on surfactant and drug loading effects.
PubMed:FA-loaded lipid drug delivery systems: preparation, characterization and biological studies.
PubMed:Influence of process parameters on properties of Nanostructured Lipid Carriers (NLC) formulation.
PubMed:Improved brain delivery of vincristine using dextran sulfate complex solid lipid nanoparticles: optimization and in vivo evaluation.
PubMed:Modeling the effect of sonication parameters on size and dispersion temperature of solid lipid nanoparticles (SLNs) by response surface methodology (RSM).
PubMed:All-trans retinoic acid-loaded lipid nanoparticles as a transdermal drug delivery carrier.
PubMed:Lipid nanoparticles based on butyl-methoxydibenzoylmethane: in vitro UVA blocking effect.
PubMed:Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation.
PubMed:In vitro evaluation on a model of blood brain barrier of idebenone-loaded solid lipid nanoparticles.
PubMed:Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway.
PubMed:Combined strategies of apomorphine diester prodrugs and nanostructured lipid carriers for efficient brain targeting.
PubMed:Multivariate design for the evaluation of lipid and surfactant composition effect for optimisation of lipid nanoparticles.
PubMed:Preparation and optimization of PIT solid lipid nanoparticles via statistical factorial design.
PubMed:Fabrication, appraisal, and transdermal permeation of sildenafil citrate-loaded nanostructured lipid carriers versus solid lipid nanoparticles.
PubMed:Loading hydrophilic drug in solid lipid media as nanoparticles: statistical modeling of entrapment efficiency and particle size.
PubMed:Nanostructured lipid carriers (NLC) for parenteral delivery of an anticancer drug.
PubMed:Development and validation of a simple reversed-phase HPLC method for the determination of camptothecin in animal organs following administration in solid lipid nanoparticles.
PubMed:In vivo real-time fluorescence visualization and brain-targeting mechanisms of lipid nanocarriers with different fatty ester:oil ratios.
PubMed:Dissolution of solid lipid extrudates in biorelevant media.
PubMed:Hydrophilic coating of mitotane-loaded lipid nanoparticles: preliminary studies for mucosal adhesion.
PubMed:Lipid nanoparticles for brain targeting I. Formulation optimization.
PubMed:Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies.
PubMed:Cysteine proteinase type I, encapsulated in solid lipid nanoparticles induces substantial protection against Leishmania major infection in C57BL/6 mice.
PubMed:Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure.
PubMed:In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain.
PubMed:Cationic solid lipid nanoparticles loaded by cysteine proteinase genes as a novel anti-leishmaniasis DNA vaccine delivery system: characterization and in vitro evaluations.
PubMed:Physicochemical characterization and in vivo bioluminescence imaging of nanostructured lipid carriers for targeting the brain: apomorphine as a model drug.
PubMed:The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein-loaded SLN prepared by the double emulsion process.
PubMed:Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.
PubMed:Fatty acyl-CoA reductase and wax synthase from Euglena gracilis in the biosynthesis of medium-chain wax esters.
PubMed:Nondestructive rheological measurement of aqueous dispersions of solid lipid nanoparticles: effects of lipid types and concentrations on dispersion consistency.
PubMed:Chemical and structural investigation of lipid nanoparticles: drug-lipid interaction and molecular distribution.
PubMed:Corticosteroid solubility and lipid polarity control release from solid lipid nanoparticles.
PubMed:Lipid nanoparticles with different oil/fatty ester ratios as carriers of buprenorphine and its prodrugs for injection.
PubMed:Human mitochondrial oxidative capacity is acutely impaired after burn trauma.
PubMed:Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC.
PubMed:In vitro skin permeation of sunscreen agents from O/W emulsions.
PubMed:The effect of cetyl palmitate crystallinity on physical properties of gamma-oryzanol encapsulated in solid lipid nanoparticles.
PubMed:Oral insulin delivery by means of solid lipid nanoparticles.
PubMed:Cetyl palmitate-based NLC for topical delivery of Coenzyme Q(10) - development, physicochemical characterization and in vitro release studies.
PubMed:Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics.
PubMed:A water activity control system for enzymatic reactions in organic media.
PubMed:Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training.
PubMed:Solid lipid nanoparticles (SLN)--effects of lipid composition on in vitro degradation and in vivo toxicity.
PubMed:Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN).
PubMed:Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique.
PubMed:The development of Cutina lipogels and gel microemulsion for topical administration of fluconazole.
PubMed:Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects.
PubMed:Semisolid SLN dispersions for topical application: influence of formulation and production parameters on viscoelastic properties.
PubMed:Wax ester production from n-alkanes by Acinetobacter sp. strain M-1: ultrastructure of cellular inclusions and role of acyl coenzyme A reductase.
PubMed:Myristyl and palmityl acylation of pI 5.1 carboxylesterase from porcine intestine and liver.
PubMed:Solid lipid nanoparticles (SLN)--a novel carrier for UV blockers.
PubMed:Bioavailability of diazepam from aqueous-organic solution, submicron emulsion and solid lipid nanoparticles after rectal administration in rabbits.
PubMed:Encapsulation of retinoids in solid lipid nanoparticles (SLN).
PubMed:Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol.
PubMed:Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages.
PubMed:Comparison of wax and glyceride solid lipid nanoparticles (SLN).
PubMed:Crystallographic investigation of cetylpalmitate solid lipid nanoparticles.
PubMed:Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products.
PubMed:Spray-drying of solid lipid nanoparticles (SLN TM).
PubMed:Plasma lipoproteins as targeting carriers to tumour tissues after administration of a lipophilic agent to mice.
PubMed:Effect of topical preparation of mycophenolic acid on experimental allergic contact dermatitis of guinea-pigs induced by dinitrofluorobenzene.
PubMed:Mechanism of free fatty acid effects on hepatocyte insulin receptor binding and processing.
PubMed:Lipid conjugates of antiretroviral agents. II. Disodium palmityl phosphonoformate: anti-HIV activity, physical properties, and interaction with plasma proteins.
PubMed:Export of mitochondrially synthesized lysophosphatidic acid.
PubMed:The esterase profile of a lipase from Candida cylindracea.
PubMed:Isolation and characterization of a fatty acid binding protein in adipose tissue of Gallus domesticus.
PubMed:Physicochemical properties of dexamethasone palmitate, a high fatty acid ester of an anti-inflammatory drug: polymorphism and crystal structure.
PubMed:3 beta-O-palmityl longispinogenin from Trichocereus chilensis.
PubMed:Selective uptake of HDL cholesterol ester by human fat cells.
PubMed:Inhibition of myocardial lipase by palmityl CoA.
PubMed:Control of fatty acid oxidation by intramitochondrial [NADH]/[NAD+] in developing rat small intestine.
PubMed:Palmitylation, sulfation, and glycosylation of the alpha subunit of the sodium channel. Role of post-translational modifications in channel assembly.
PubMed:Myristyl and palmityl acylation of the insulin receptor.
PubMed:Complementation analysis of fatty acid oxidation disorders.
PubMed:The role of fatty acids in ischemic tissue injury: difference between oleic and palmitic acid.
PubMed:The multiple acyl-coenzyme A dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria. Mitochondrial fatty acid oxidation, acyl-coenzyme A dehydrogenase, and electron transfer flavoprotein activities in fibroblasts.
PubMed:Acyl-CoA reductase and acyl-CoA: fatty alcohol acyl transferase in the microsomal preparation from the bovine meibomian gland.
PubMed:Stimulation of a neutral triacylglycerol hydrolase from rat heart by phosphatidylethanolamine and lysophosphatidylethanolamine.
PubMed:Malonyl CoA inhibition of carnitine palmityltransferase in rat heart mitochondria.
PubMed:Inhibition of the adenine nucleotide translocator by matrix-localized palmityl-CoA in rat heart mitochondria.
PubMed:Skeletal muscle fatty acid oxidation during early postnatal development in the rat.
PubMed:Palmitate oxidation in human muscle: comparison to CPT and carnitine.
PubMed:Perinatal changes in mitochondrial respiration of the rabbit heart.
PubMed:Coenzyme A activation of acetyl-CoA carboxylase.
PubMed:Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria.
PubMed:A possible role of Z protein in dietary control of hepatic triacylglycerol synthesis.
PubMed:Kinetic properties of fatty acid synthetase of Neurospora crassa.
PubMed:Training adaptations in skeletal muscle of juvenile diabetics.
PubMed:Palmityl-CoA and stearyl-CoA desaturase in mouse brain microsomes during development in normal and neurological mutants (Quaking and Jimpy).
PubMed:Collaborative study of a GLC method for vitamin E.
PubMed:Biochemical and morphological correlates of acute experimental myocardial ischemia in the dog. IV. Energy mechanisms during very early ischemia.
PubMed:[Aqueous petroleum-oxidizing Arthrobacter].
PubMed:Effects of palmityl coenzyme A and palmitylcarnitine on phosphorylating respiration in heart mitochondria.
PubMed:Triglyceride synthesis from dihydroxyacetone phosphate and palmitate by microsomes from mammary glands of lactating mice.
PubMed:Mechanism of palmityl coenzyme A inhibition of liver glycogen synthase.
PubMed:The palmityl binding sites of fatty acid synthetase from yeast.
PubMed:Heart mitochondrial metabolism after feeding herring oil to rats and monkeys.
PubMed:A case of lipid storage myopathy with carnitine deficiency. Biochemical and electromyographic correlations.
PubMed:The role of acyltransferases in fatty acid utilization.
PubMed:Optimum conditions for the oxidation of palmityl-carnitine by the mitochondria of rat brown adipose tissue.
PubMed:Acylation of carnitine and glycerophosphate in suspensions of rat liver mitochondria at varying levels of palmitate and coenzyme A.
PubMed:Hydrolysis of plant cuticle by plant pathogens. Properties of cutinase I, cutinase II, and a nonspecific esterase isolated from Fusarium solani pisi.
PubMed:Erucic acid metabolism by rat heart preparations.
PubMed:Changes in composition, biosynthesis, and physical state of membrane lipids occurring upon aging of Mycoplasma hominis cultures.
PubMed:beta-Hydroxy fatty acid production during fatty acid oxidation by heart mitochondria.
PubMed:Comparative studies on nicotinamide nucleotide transhydrogenase from different sources.
PubMed:Wax esters in fish. Metabolism of dietary palmityl palmitate in the gourami (Trichogaster cosby).
PubMed:Adaptation of muscle to exercise. Increase in levels of palmityl Coa synthetase, carnitine palmityltransferase, and palmityl Coa dehydrogenase, and in the capacity to oxidize fatty acids.
PubMed:Temperature control of phospholipid biosynthesis in Escherichia coli.
PubMed:[Formation of cetyl palmitate from n-hexadecane by Mycobacterium strain 3' cultures].
PubMed:Control of fatty acid metabolism. I. Induction of the enzymes of fatty acid oxidation in Escherichia coli.
PubMed:ORIGIN OF PALMITIC ACID CARBON IN PALMITATES FORMED FROM HEXADECANE-1-C-14 AND TETRADECANE-1-C-14 BY MICROCOCCUS CERIFICANS.
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