| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 4602-84-0 |
| ECHA EC Number: | 225-004-1 |
| FDA UNII: | EB41QIU6JL |
| CoE Number: | 78 |
| Category: | cosmetic, flavor and fragrance agents |
| IUPAC Name: | farnesol |
| InChI : | InChI=1/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3 |
| Std.InChI: | InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3 |
| InChIKey : | CRDAMVZIKSXKFV-UHFFFAOYAI |
| Std.InChIKey: | CRDAMVZIKSXKFV-UHFFFAOYSA-N |
| SMILES : | CC(=CCCC(=CCCC(=CCO)C)C)C |
| MDL: | MFCD00002918 |
| Molar Refractivity : | 72.77 ± 0.3 cm3 (est) |
| Parachor : | 585.8 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.485 ± 0.02 (est) |
| Surface Tension : | 30.3 ± 3.3 dyne/cm (est) |
| Density : | 0.875 ± 0.06 g/cm3 (est) |
| Polarizability : | 28.85 ± 0.5 10-24cm3 (est) |
| Fragrance Demo Formulas | |
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1230 farnesol |
| DG SANTE Food Flavourings: | 02.029 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol |
| FEMA Number: | 2478 farnesol |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 4602-84-0 ; FARNESOL |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. | |
| Appearance: | colorless to pale yellow clear oily liquid (est) |
| Assay: | 96.00 to 100.00 sum of isomers |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 0.88400 to 0.88900 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 7.356 to 7.397 |
| Refractive Index: | 1.48700 to 1.49200 @ 20.00 °C. |
| Boiling Point: | 149.00 °C. @ 4.00 mm Hg |
| Boiling Point: | 263.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.000370 mmHg @ 25.00 °C. (est) |
| Vapor Density: | >1 ( Air = 1 ) |
| Flash Point: | 205.00 °F. TCC ( 96.11 °C. ) |
| logP (o/w): | 4.828 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: | |
| alcohol | |
| water, 1.287 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
| Stability: | |
| cream | |
| hair spray | |
| lipstick | |
| lotion | |
| non-discoloring in most media | |
| powder | |
| soap | |
| Associate Allied Chemicals |
| Farnesol P |
| About |
| Augustus Oils |
| Farnesol |
| Services |
| Aurochemicals |
| FARNESOL, Natural |
| Bedoukian Research |
| FARNESOL ≥96.0% (sum of isomers), FCC, Kosher Odor: A delicate, fresh, green muguet note Use: Used in rose and other floral compositions. Flavor: Floral, woody, dry Woody, dry notes for cranberry, tea. |
| Berjé |
| Farnesol Synthetic |
| Media |
| BOC Sciences |
| For experimental / research use only. |
| FARNESOL FCC 96.0% (sum of isomers) |
| Creatingperfume.com |
| Farnesol Symrise Odor: Delicate, fresh, green muguet note |
| Diffusions Aromatiques |
| FARNESOL |
| EMD Millipore |
| For experimental / research use only. |
| Farnesol |
| Ernesto Ventós |
| FARNESOL Odor: FLORAL, SWEET, GREEN |
| Excellentia International |
| Farnesol Natural |
| ExtraSynthese |
| For experimental / research use only. |
| Farnesol |
| Indukern F&F |
| FARNESOL Odor: GREEN, FRESH, FLORAL |
| Jiangyin Healthway |
| Farnesol |
| New functional food ingredients |
| Lluch Essence |
| FARNESOL |
| Moellhausen |
| FARNESOL Odor: delicate, fresh green; floral, muguet-note |
| Pell Wall Perfumes |
| Farnesol |
| Penta International |
| FARNESOL FCC |
| Penta International |
| FARNESOL |
| PerfumersWorld |
| Farnesol |
| Perfumery Laboratory |
| Farnesol Symrise Odor: gentle, sweet, fresh fragrance with shades of lime and lily-of-the-valley flowers |
| Prodasynth |
| FARNESOL (SUM OF ISOMERS > 96%) Odor: FLORAL, SWEET, GREEN |
| Reincke & Fichtner |
| Farnesol |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Farnesol ≥97% |
| Sigma-Aldrich |
| Farnesol, mixture of isomers, ≥95%, stabilized, FG Odor: anise; apricot; balsam; clove; grapefruit; oily; orange; floral; peach; pear |
| Certified Food Grade Products |
| SRS Aromatics |
| FARNESOL |
| Symrise |
| Dragosantol® Bisabolol and Farnesol Odor: characteristic Use: Dragosantol® contains at least 85 % of d,l-alpha-bisabolol, a monocyclic unsaturated sesquiterpene alcohol. Ingredients of secondary importance are mainly farnesol isomers. Dragosantol® has been shown to possess soothing properties for stressed and sensitive skin. Moreover, body odor control effectiveness has been demonstrated both for d,l-alpha-bisabolol and for Dragosantol®.Dragosantol® is suitable for use in cosmetic products due to its stability and good compatibility to the skin. The main areas of application for Dragosantol® are skin care cosmetic preparations, in particular lotions and creams for sensitive skin. Unlike Azulen or camomile oil, Dragosantol® does not alter its color after long storage periods nor diffuse through plastic containers; therefore it can be used without problems. |
| Symrise |
| Farnesol Plus Odor: characteristic Use: Farnesol Plus is a nature identical, synergistic complex of active ingredients with deodorising properties. Farnesol Plus is composed of Farnesol, Phenoxyethanol, Glycerine monolaurate. |
| Symrise |
| Farnesol special Odor: very mild and delicate green floral odor with typical lily of the valley character Use: Stable in: body lotion (very good), shampoo (good), soap (good), ap roll-on (poor), powder (poor), cleaner citric (poor), cleaner apc (very good), bleach (poor). Flavor: sweet, flowery, juicy Useful in: mint, fruity citrus, fruity red, fruity yellow, fruity tropical, fruity others, sweet others, alcoholics. |
| TCI AMERICA |
| For experimental / research use only. |
| Farnesol (mixture of isomers) |
| Vigon International |
| Farnesol |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36/38 - Irritating to skin and eyes. R 43 - May cause sensitisation by skin contact. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Acute aquatic toxicity (Category 2), H401 Chronic aquatic toxicity (Category 2), H411 | |
| GHS Label elements, including precautionary statements | |
| Pictogram |  |
| Signal word | Warning |
| Hazard statement(s) | |
| H401 - Toxic to aquatic life H411 - Toxic to aquatic life with long lasting effects | |
| Precautionary statement(s) | |
| P273 - Avoid release to the environment. P391 - Collect spillage. Hazardous to the aquatic environment P501 - Dispose of contents/ container to an approved waste disposal plant. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 6000 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ANTIPSYCHOTIC Therapie. Vol. 27, Pg. 893, 1972. oral-mouse LD50 7400 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ANTIPSYCHOTIC Therapie. Vol. 27, Pg. 893, 1972. intraperitoneal-mouse LD50 443 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ANTIPSYCHOTIC Therapie. Vol. 27, Pg. 893, 1972. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 > 5000 mg/kg Therapie. Vol. 27, Pg. 893, 1972. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| cosmetic, flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| IFRA Critical Effect: | |||
| Dermal sensitization | |||
| View the IFRA Standard | |||
| View IFRA Standards Library for complete information. | |||
| Please review Amendment 49 IFRA documentation for complete information. | |||
| IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%): | |||
| Category 1: Products applied to the lips | |||
| 0.21 % | |||
| Category 2: Products applied to the axillae | |||
| 0.062 % | |||
| Category 3: Products applied to the face/body using fingertips | |||
| 1.20 % | |||
| Category 4: Products related to fine fragrance | |||
| 1.20 % | |||
| Category 5: Products applied to the face and body using the hands (palms), primarily leave-on | |||
| Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on | |||
| 0.29 % | |||
| Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on | |||
| 0.29 % | |||
| Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on | |||
| 0.29 % | |||
| Category 5D: Baby Creams, baby Oils and baby talc | |||
| 0.29 % | |||
| Category 6: Products with oral and lip exposure | |||
| 0.68 % | |||
| Category 7: Products applied to the hair with some hand contact | |||
| Category 7A: Rinse-off products applied to the hair with some hand contact | |||
| 2.40 % | |||
| Category 7B: Leave-on products applied to the hair with some hand contact | |||
| 2.40 % | |||
| Category 8: Products with significant anogenital exposure | |||
| 0.12 % | |||
| Category 9: Products with body and hand exposure, primarily rinse off | |||
| 2.30 % | |||
| Category 10: Household care products with mostly hand contact | |||
| Category 10A: Household care excluding aerosol products (excluding aerosol/spray products) | |||
| 8.10 % | |||
| Category 10B: Household aerosol/spray products | |||
| 8.10 % | |||
| Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate | |||
| Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure | |||
| 4.50 % | |||
| Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure | |||
| 4.50 % | |||
| Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin | |||
| No Restriction | |||
| Notes: | |||
| IFRA FLAVOR REQUIREMENTS: | |||
Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 7.70 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 2.60 (μg/capita/day) | ||
| Threshold of Concern: | 1800 (μg/person/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 1.70000 | |
| beverages(nonalcoholic): | - | 0.76000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 0.40000 | |
| fruit ices: | - | 0.40000 | |
| gelatins / puddings: | - | 0.10000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 1.40000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Flavouring Group Evaluation 202: 3-Alkylated aliphatic acyclic alpha,beta-unsaturated aldehydes and precursors with or without additional double bonds from chemical subgroup 1.1.3 of FGE.19[1] View page or View pdf |
| Flavouring Group Evaluation 72 (FGE.72): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids. Esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2 (2010) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 95 (FGE.95): Consideration of aliphatic, linear or branched-chain saturated and unsaturated alcohols, aldehydes, acids and related esters evaluated by JECFA (69th meeting) structurally related to esters of branched- and straight-chain aliphatic saturated primary alcohols and of one secondary alcohol, and branched- and straight-chain unsaturated carboxylic acids evaluated by EFSA in FGE.05Rev1 (2008) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 72, Revision 1 (FGE.72Rev1): Consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids, and related esters evaluated by the JECFA (61st meeting) structurally related to branched- and straight-chain unsaturated carboxylic acids, esters of these and straight-chain aliphatic saturated alcohols evaluated by EFSA in FGE.05Rev2 View page or View pdf |
| Safety and efficacy of a,�-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 72, Revision 2 (FGE.72Rev2): consideration of aliphatic, branched-chain saturated and unsaturated alcohols, aldehydes, acids and related esters evaluated by JECFA (61st, 68th and 69th meetings) and structurally related to flavouring substances in FGE.05Rev3 View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):4602-84-0 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :3327 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WGK Germany:2 |
| 3,7,11-trimethyldodeca-2,6,10-trien-1-ol |
| Chemidplus:0004602840 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:JR4979000 for cas# 4602-84-0 |
| 3,7,11-trimethyldodeca-2,6,10-trien-1-ol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 4602-84-0 |
| Pubchem (cid): | 3327 |
| Pubchem (sid): | 134986027 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| KEGG (GenomeNet): | C01126 |
| HMDB (The Human Metabolome Database): | HMDB04305 |
| FooDB: | FDB014891 |
| Export Tariff Code: | 2905.22.5050 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
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| orangeflower water absolute @ 0.0-1.9% Data GC Search Trop Picture | |
| oregano shoot Search Trop Picture | |
| osmanthus absolute @ 0.18% Data GC Search Trop Picture | |
| palmarosa Search Trop Picture | |
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| rose absolute morocco @ 0.60% Data GC Search Trop Picture | |
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| sideritis syriaca l. oil bulgaria @ 3.40% Data GC Search Trop Picture | |
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| wine Search Picture | |
| ylang ylang Search Trop Picture | |
| zingiber officinale root oil china @ 0.34% Data GC Search Trop Picture |
| 2,6,10- | dodecatrien-1-ol, 3,7,11-trimethyl- |
| dragosantol (Symrise) | |
| farnesol FCC | |
| farnesol special | |
| farnesol synthetic | |
| farnesyl alcohol | |
| 3,7,11- | trimethyl dodeca-2,6,10-trienol |
| 3,7,11- | trimethyl-2,6,10-dodecatrien-1-ol |
| 2,6,10- | trimethyl-2,6,10-dodecatrien-12-ol |
| 3,7,11- | trimethyl-2,6,10-dodecatrienol |
| 3,7,11- | trimethyldodeca-2,6,10-trien-1-ol |
