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perfluorooctyl bromide

solvents
2D:
3D:
CAS Number: 423-55-2
ECHA EC Number: 207-028-4
FDA UNII: Q1D0Q7R4D9
Category: solvents
IUPAC Name: perfluorooctyl bromide
InChI : InChI=1/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26
Std.InChI: InChI=1S/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26
InChIKey : WTWWXOGTJWMJHI-UHFFFAOYAJ
Std.InChIKey: WTWWXOGTJWMJHI-UHFFFAOYSA-N
SMILES : C(C(C(C(C(F)(F)Br)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F
MDL: MFCD00042082
Molar Refractivity : 49.35 ± 0.3 cm3 (est)
Parachor : 524.9 ± 4.0 cm3 (est)
Index of Refraction : 1.296 ± 0.02 (est)
Surface Tension : 14.9 ± 3.0 dyne/cm (est)
Density : 1.870 ± 0.06 g/cm3 (est)
Polarizability : 19.56 ± 0.5 10-24cm3 (est)

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search

Physical Properties:

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.93000 @ 25.00 °C.
Boiling Point: 141.00 °C. @ 760.00 mm Hg
Vapor Pressure:6.500000 mmHg @ 25.00 °C. (est)
Flash Point: 106.00 °F. TCC ( 40.90 °C. ) (est)
logP (o/w): 8.620 (est)
Soluble in:
water, 0.0003212 mg/L @ 25 °C (est)

Cosmetic Information:

CosIng:cosmetic data
Cosmetic Uses: solvents

Suppliers:

BOC Sciences
For experimental / research use only.
PerfluorooCtyl bromide >98.0%(GC)
Matrix Scientific
For experimental / research use only.
1-Bromoperfluorooctane, 98%
Santa Cruz Biotechnology
For experimental / research use only.
1-Bromoheptadecafluorooctane ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
1-Bromoheptadecafluorooctane 99%
TCI AMERICA
For experimental / research use only.
Heptadecafluoro-n-octyl Bromide >98.0%(GC)

Safety Information:

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 14720 mg/kg
Microvascular Research. Vol. 8, Pg. 320, 1974.

unreported-mouse LD50 42500 mg/kg
Biomaterials, Artificial Cells, and Artificial Organs. Vol. 16, Pg. 441, 1988.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
solvents
Recommendation for perfluorooctyl bromide usage levels up to:
not for fragrance use.
Recommendation for perfluorooctyl bromide flavor usage levels up to:
not for flavor use.

Safety References:

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9873
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
Chemidplus:0000423552
RTECS:RG8700000 for cas# 423-55-2

References:

1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):9873
Pubchem (sid):134973983

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D05439
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2903.79.9070
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View

Potential Blenders and core components :

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):

not found in nature

Synonyms:

1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
1-bromoheptadecafluorooctane
1-bromoperfluorooctane
perfluoro-N-octyl bromide
perfluoroctyl bromide
perfluoroctylbromide
perfluorooctylbromide
heptadecafluoro-N-octyl bromide
heptadecafluorooctyl bromide
imagent GI
octane, 1-bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-
oxygent HT
perflubron

Articles:

PubMed:Balanced UTE-SSFP for (19) F MR imaging of complex spectra.
PubMed:High-frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules.
PubMed:Probing different perfluorocarbons for in vivo inflammation imaging by 19F MRI: image reconstruction, biological half-lives and sensitivity.
PubMed:RGD decoration of PEGylated polyester nanocapsules of perfluorooctyl bromide for tumor imaging: influence of pre or post-functionalization on capsule morphology.
PubMed:Microfluidic fabrication of monodisperse polylactide microcapsules with tunable structures through rapid precipitation.
PubMed:Effects of Achilles tendon immersion in saline and perfluorochemicals on T2 and T2*.
PubMed:Using fluorochemical as oxygen carrier to enhance the growth of marine microalga Nannochloropsis oculata.
PubMed:Addition of perfluorocarbons to alginate hydrogels significantly impacts molecular transport and fracture stress.
PubMed:Long-circulating perfluorooctyl bromide nanocapsules for tumor imaging by 19FMRI.
PubMed:Exceptionally stable fluorous emulsions for the intravenous delivery of volatile general anesthetics.
PubMed:Interaction of melittin peptides with perfluorocarbon nanoemulsion particles.
PubMed:High sensitivity 19F MRI of a perfluorooctyl bromide emulsion: application to a dynamic biodistribution study and oxygen tension mapping in the mouse liver and spleen.
PubMed:Perfluorocarbon emulsions prevent hypoxia of pancreatic β-cells.
PubMed:Fluorocapsules for improved function, immunoprotection, and visualization of cellular therapeutics with MR, US, and CT imaging.
PubMed:Regional overdistension identified with electrical impedance tomography in the perflubron-treated lung.
PubMed:Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles.
PubMed:Partitioning of homologous nicotinic acid ester prodrugs (nicotinates) into dipalmitoylphosphatidylcholine (DPPC) membrane bilayers.
PubMed:The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent.
PubMed:Detection of fluorine labeled herceptin using cellular (19)F MRI ex vivo.
PubMed:Gels from a semifluorinated n-alkane in fluorinated solvents as a probe for intermolecular interactions.
PubMed:Non-toxicity of IV injected perfluorocarbon oxygen carrier in an animal model of liver regeneration following surgical injury.
PubMed:Phospholipid decoration of microcapsules containing perfluorooctyl bromide used as ultrasound contrast agents.
PubMed:Quantification of pegylated phospholipids decorating polymeric microcapsules of perfluorooctyl bromide by reverse phase HPLC with a charged aerosol detector.
PubMed:Surfactant dependent morphology of polymeric capsules of perfluorooctyl bromide: influence of polymer adsorption at the dichloromethane-water interface.
PubMed:Hydrogel-perfluorocarbon composite scaffold promotes oxygen transport to immobilized cells.
PubMed:Synthesis, physicochemical properties and in vitro cytotoxicity of nicotinic acid ester prodrugs intended for pulmonary delivery using perfluorooctyl bromide as vehicle.
PubMed:Perfluorocarbon emulsions cytotoxic effects on human fibroblasts and effect of aging on particle size distribution.
PubMed:Potential use of fluorocarbons in lung surfactant therapy.
PubMed:The detrimental effect of serum albumin on the re-spreading of a dipalmitoyl phosphatidylcholine Langmuir monolayer is counteracted by a fluorocarbon gas.
PubMed:Two-compartment radial diffusive exchange analysis of the NMR lineshape of (129)Xe dissolved in a perfluorooctyl bromide emulsion.
PubMed:Polymeric nano/microcapsules of liquid perfluorocarbons for ultrasonic imaging: physical characterization.
PubMed:Fluidization of a dipalmitoyl phosphatidylcholine monolayer by fluorocarbon gases: potential use in lung surfactant therapy.
PubMed:Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144.
PubMed:Intrapulmonary perfluorooctyl bromide instillation in fetal rabbits.
PubMed:Cosurfactant effect of a semifluorinated alkane at a fluorocarbon/water interface: impact on the stabilization of fluorocarbon-in-water emulsions.
PubMed:Understanding the fundamentals of perfluorocarbons and perfluorocarbon emulsions relevant to in vivo oxygen delivery.
PubMed:Molecular dynamics averaging of Xe chemical shifts in liquids.
PubMed:Artificial oxygen carriers as red blood cell substitutes: a selected review and current status.
PubMed:Effect of meconium on the surface properties of perflubron.
PubMed:Mechanism of perfluoroalkyl halide toxicity: catalysis of perfluoroalkylation by reduced forms of cobalamin (vitamin B12).
PubMed:Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems.
PubMed:Effect of perfluorooctyl bromide on bacterial growth.
PubMed:Pulmonary drug delivery systems: recent developments and prospects.
PubMed:Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization.
PubMed:Combined bactericidal activity of perfluorooctyl bromide and aminoglycosides against Pseudomonas aeruginosa.
PubMed:Perfluorooctyl bromide has limited membrane solubility and is located at the bilayer center. Locating small molecules in lipid bilayers through paramagnetic enhancements of NMR relaxation.
PubMed:Evaluation of cytotoxicity of new semi-fluorinated amphiphiles derived from dimorpholinophosphate.
PubMed:Effect of perfluorocarbon (perfluorooctyl bromide) vapor on tidal volume measurement during partial liquid ventilation.
PubMed:Reverse water-in-fluorocarbon emulsions for use in pressurized metered-dose inhalers containing hydrofluoroalkane propellants.
PubMed:Improvements in the ultrasonic contrast of targeted perfluorocarbon nanoparticles using an acoustic transmission line model.
PubMed:Pulmonary arterial morphometry from microfocal X-ray computed tomography.
PubMed:Microfocal X-ray CT imaging and pulmonary arterial distensibility in excised rat lungs.
PubMed:Compatibility of different colloid plasma expanders with perflubron emulsion: an intravital microscopic study in the hamster.
PubMed:Assay method for the perfluorooctyl bromide (perflubron) in rat blood by gas chromatography-mass spectrometry.
PubMed:Perfluorocarbon emulsions as intravenous delivery media for hyperpolarized xenon.
PubMed:Solubility enhancement of phenol and phenol derivatives in perfluorooctyl bromide.
PubMed:Perfluorooctyl bromide (perflubron) stimulates mucin secretion in the ferret trachea.
PubMed:Influence of intravenous perfluorocarbon administration on the dynamic behavior of lung surfactant.
PubMed:Perfluorocarbon induced alterations in pulmonary mechanics.
PubMed:Effects of perfluorocarbon emulsions on cultured human endothelial cells.
PubMed:Aerobic preservation of organs using a new perflubron/lecithin emulsion stabilized by molecular dowels.
PubMed:Regional myocardial oxygen tension: 19F MRI of sequestered perfluorocarbon.
PubMed:Time versus density enhancement of liver, spleen, and great vessels following rapid intravenous infusion of perflubron emulsion.
PubMed:Rat multiple organ blocks perfused with perfluorooctyl bromide emulsions.
PubMed:Improvement in circulatory and oxygenation status by perflubron emulsion (Oxygent HT) in a canine model of surgical hemodilution.
PubMed:Characterization and mechanism of side-effects of Oxygent HT (highly concentrated fluorocarbon emulsion) in swine.
PubMed:Normothermic preservation of "multiple organ blocks" with a new perfluorooctyl bromide emulsion.
PubMed:Intracellular and extracellular transport of perfluoro carbon emulsion from subcutaneous tissue to regional lymphatics.
PubMed:Novel injectable fluorinated contrast agents with enhanced radiopacity.
PubMed:Oxygenation during perfluorocarbon associated gas exchange in normal and abnormal lungs.
PubMed:Effects of formulation, processing and storage parameters on the characteristics and stability of perflubron emulsion.
PubMed:Effects of buffer pH and phosphate concentration on the droplet size and EYP hydrolysis of perflubron/EYP emulsions.
PubMed:Mixed fluorocarbon/hydrocarbon molecular dowels help protect concentrated fluorocarbon emulsions with large size droplets against coalescence.
PubMed:Lung functions after intravenous or intraperitoneal administration of perfluorooctyl bromide (PFOB) or perfluorotributylamine (FTBA) emulsions.
PubMed:Perfluorocarbon distribution to liver, lung and spleen of emulsions of perfluorotributylamine (FTBA) in pigs and rats and perfluorooctyl bromide (PFOB) in rats and dogs by 19F NMR spectroscopy.
PubMed:Phagocytosis of a fluorescently labeled perflubron emulsion by a human monocyte cell line.
PubMed:Improved control over particle sizes and stability of concentrated fluorocarbon emulsions by using mixed fluorocarbon/hydrocarbon molecular dowels.
PubMed:Room temperature stable perfluorocarbon emulsions with acceptable half-lives in the reticuloendothelial system.
PubMed:Influence of perflubron emulsion particle size on blood half-life and febrile response in rats.
PubMed:Enhanced oxygen delivery by perflubron emulsion during acute hemodilution.
PubMed:Ex vivo normothermic preservation of rat multiple organ blocks using a perfluorooctyl bromide emulsion as oxygen carrier.
PubMed:Value of brominated fluorocarbons for the radiographic diagnosis of small-bowel obstruction: comparison with other contrast agents in rats.
PubMed:Radiosensitivity, blood perfusion and tumour oxygenation after perflubron emulsion injection.
PubMed:A new perfluorocarbon for use in fluorine-19 magnetic resonance imaging and spectroscopy.
PubMed:Inhibition of endotoxin-mediated activation of endothelial cells by a perfluorocarbon emulsion.
PubMed:Perfluorooctyl bromide dispersions in aqueous media for biomedical applications.
PubMed:New perfluorocarbon emulsion improves tissue oxygenation in cat retina.
PubMed:Correction of chemical-shift artifacts in multislice F-19 imaging with perfluorooctyl bromide.
PubMed:A new concentrated perfluorochemical emulsion and carbogen breathing as an adjuvant to treatment with antitumor alkylating agents.
PubMed:Overview of progress in the fluorocarbon approach to in vivo oxygen delivery.
PubMed:Influence of the 100% w/v perfluorooctyl bromide (PFOB) emulsion dose on tumour radiosensitivity.
PubMed:Detection of tumors with 19F magnetic resonance imaging.
PubMed:Rapid 19F magnetic resonance imaging of perfluorooctyl bromide in vivo.
PubMed:Perfluorooctyl bromide concentration in plasma and tissues of beagle dogs.
PubMed:Perfluorooctyl bromide: a potential antiobesity compound.
PubMed:Perfluoro carbon bromides as contrast media in radiography of the central nervous system. A preliminary experimental report.
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