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ferric citrate

nutrient supplements
2D:
3D:
CAS Number: 28633-45-6
ECHA EC Number: 249-117-0
FDA UNII: 63G354M39Z
Category: nutrient supplements
IUPAC Name: ferric citrate
InChI : InChI=1/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3
Std.InChI: InChI=1S/C6H8O7.Fe/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);/q;+3/p-3
InChIKey : NPFOYSMITVOQOS-DFZHHIFOAO
Std.InChIKey: NPFOYSMITVOQOS-UHFFFAOYSA-K
SMILES : C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Fe+3]

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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FDA/DG SANTE Petitions, Reviews, Notices:
184.1307c Ferric citrate View - review
184.1298 Ferric citrate View - review
FDA Mainterm (SATF):28633-45-6 ; FERRIC CITRATE

Physical Properties:

Food Chemicals Codex Listed: No
Boiling Point: 309.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000057 mmHg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.20 °C. ) (est)
logP (o/w): -1.721 (est)

Cosmetic Information:

None found

Suppliers:

American Elements
Ferric Citrate 99%
Odor: characteristic
Use: Ferric Citrate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.

Safety Information:

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
nutrient supplements
Recommendation for ferric citrate usage levels up to:
not for fragrance use.
Recommendation for ferric citrate flavor usage levels up to:
not for flavor use.

Safety References:

EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61300
National Institute of Allergy and Infectious Diseases:Data
2-hydroxypropane-1,2,3-tricarboxylate; iron(3+)
Chemidplus:0002338058

References:

2-hydroxypropane-1,2,3-tricarboxylate; iron(3+)
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):61300
Pubchem (sid):135017445

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
FooDB:FDB013680
FDA Listing of Food Additive Status:View
ChemSpider:View

Potential Blenders and core components :

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):

not found in nature

Synonyms:

citric acid iron(3+) salt
2-hydroxypropane-1,2,3-tricarboxylate; iron(3+)
iron(III) citrate

Articles:

PubMed:Enhancement of Non-heme Iron Absorption by Anchovy (Engraulis japonicus) Muscle Protein Hydrolysate Involves a Nanoparticle-Mediated Mechanism.
PubMed:Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.
PubMed:Role of ferric reductases in iron acquisition and virulence in the fungal pathogen Cryptococcus neoformans.
PubMed:Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1).
PubMed:Effect of iron liposomes on anemia of inflammation.
PubMed:Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice.
PubMed:High bioavailability iron maize (Zea mays L.) developed through molecular breeding provides more absorbable iron in vitro (Caco-2 model) and in vivo (Gallus gallus).
PubMed:Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin.
PubMed:Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism.
PubMed:Iron and zinc concentrations in grain and flour of winter wheat as affected by foliar application.
PubMed:Accelerating glycolytic flux of Torulopsis glabrata CCTCC M202019 at high oxidoreduction potential created using potassium ferricyanide.
PubMed:A thioredoxin reductase-like protein from the thermophile, Thermus scotoductus SA-01, displaying iron reductase activity.
PubMed:Transport of iron bound to recombinant human lactoferrin from rice and iron citrate across Caco-2 cell monolayers.
PubMed:Effects of glyphosate application on seed iron and root ferric (III) reductase in soybean cultivars.
PubMed:Biodegradation of anthraquinone dyes by Shewanella sp. NTOU1 under anaerobic conditions.
PubMed:Ascorbic acid uptake affects ferritin, Dcytb and Nramp2 expression in Caco-2 cells.
PubMed:Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions.
PubMed:A cyclic AMP receptor protein-regulated cell-cell communication system mediates expression of a FecA homologue in Stenotrophomonas maltophilia.
PubMed:Isolation of a soluble and membrane-associated Fe(III) reductase from the thermophile, Thermus scotoductus (SA-01).
PubMed:Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.
PubMed:Rates of foliar penetration of chelated Fe(III): role of light, stomata, species, and leaf age.
PubMed:Inhibition of iron uptake from iron salts and chelates by divalent metal cations in intestinal epithelial cells.
PubMed:Oxidative stress and antioxidant status in mouse kidney: effects of dietary lipid and vitamin E plus iron.
PubMed:Physiological modulation of iron metabolism in rainbow trout (Oncorhynchus mykiss) fed low and high iron diets.
PubMed:Ferric citrate is half as effective as ferrous sulfate in meeting the iron requirement of juvenile tilapia, Oreochromis niloticus x O. aureus.
PubMed:Iron bioavailability and utilization in rats are lower from lime-treated corn flour than from wheat flour when they are fortified with different sources of iron.
PubMed:Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt.
PubMed:Molecular cloning and identification of UTR1 of a yeast Saccharomyces cerevisiae as a gene encoding an NAD kinase.
PubMed:Enhanced iron uptake of Saccharomyces cerevisiae by heterologous expression of a tadpole ferritin gene.
PubMed:The importance of the proportion of heme/nonheme iron in the diet to minimize the interference with calcium, phosphorus, and magnesium metabolism on recovery from nutritional ferropenic anemia.
PubMed:Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.
PubMed:Oxidative stress and antioxidant status in mouse liver: effects of dietary lipid, vitamin E and iron.
PubMed:Effects of iron replenishment on iron, calcium, phosphorus and magnesium metabolism in iron-deficient rats.
PubMed:Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.
PubMed:Reduction of exogenous ferric iron by a surface-associated ferric reductase of Listeria spp.
PubMed:Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells.
PubMed:Tumorigenicity study of ferric citrate administered orally to mice.
PubMed:Induction of oxidative single- and double-strand breaks in DNA by ferric citrate.
PubMed:Heat resistance of Listeria monocytogenes by two recovery media used with and without cold preincubation.
PubMed:Development of an improved chemically defined minimal medium for Listeria monocytogenes.
PubMed:Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic nude mice: relationship between carcinoma growth and lipid peroxidation product levels.
PubMed:Development of a protein-free medium with ferric citrate substituting transferrin for the cultivation of mouse-mouse hybridomas.
PubMed:Effect of endotoxin on colonisation of Campylobacter jejuni in infant mice.
PubMed:Effect of excess dietary iron as ferrous sulfate and ferric citrate on tissue mineral composition of sheep.
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