| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 28588-75-2 |
| ECHA EC Number: | 249-095-2 |
| FDA UNII: | E1AN38V6MA |
| CoE Number: | 723 |
| Category: | flavoring agents |
| IUPAC Name: | bis(2-methyl-3-furyl) disulfide |
| InChI : | InChI=1/C10H10O2S2/c1-7-9(3-5-11-7)13-14-10-4-6-12-8(10)2/h3-6H,1-2H3 |
| Std.InChI: | InChI=1S/C10H10O2S2/c1-7-9(3-5-11-7)13-14-10-4-6-12-8(10)2/h3-6H,1-2H3 |
| InChIKey : | OHDFENKFSKIFBJ-UHFFFAOYAZ |
| Std.InChIKey: | OHDFENKFSKIFBJ-UHFFFAOYSA-N |
| SMILES : | CC1=C(C=CO1)SSC2=C(OC=C2)C |
| MDL: | MFCD01074774 |
| Molar Refractivity : | 61.70 ± 0.4 cm3 (est) |
| Parachor : | 469.2 ± 6.0 cm3 (est) |
| Index of Refraction : | 1.622 ± 0.03 (est) |
| Surface Tension : | 51.7 ± 5.0 dyne/cm (est) |
| Density : | 1.29 ± 0.1 g/cm3 (est) |
| Polarizability : | 24.46 ± 0.5 10-24cm3 (est) |
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1066 bis(2-methyl-3-furyl) disulfide |
| DG SANTE Food Flavourings: | 13.016 bis(2-methyl-3-furyl) disulfide |
| FEMA Number: | 3259 bis(2-methyl-3-furyl)disulfide |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 28588-75-2 ; BIS(2-METHYL-3-FURYL) DISULFIDE |
| Appearance: | pale yellow to amber clear liquid (est) |
| Assay: | 98.00 to 100.00 |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.14600 to 1.15400 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 9.536 to 9.602 |
| Refractive Index: | 1.57200 to 1.58300 @ 20.00 °C. |
| Boiling Point: | 277.00 to 280.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.012000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 210.00 °F. TCC ( > 98.89 °C. ) |
| logP (o/w): | 3.345 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: | |
| alcohol | |
| water, 9.269 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
| None found |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36/38 - Irritating to skin and eyes. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| gavage-mouse LD50 [sex: M,F] 106 mg/kg (Oser, 1969b) | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| flavoring agents | |||
| Recommendation for bis(2-methyl-3-furyl) disulfide usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.27 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.70 (μg/capita/day) | ||
| NOEL (No Observed Effect Level): | 0.45 (mg/kg bw per day) | ||
| Structure Class: | II | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 5 | |||
| Click here to view publication 5 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 0.10000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | 0.10000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | 0.10000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | 0.10000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | 0.10000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 13 (FGE.13); Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 (Commission Regulation (EC) No 1565/2000 of 18 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
| Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of �Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14� evaluated by EFSA in FGE.13Rev1 (2009) View page or View pdf |
| Flavouring Group Evaluation 67 (FGE.67): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 65, Revision 1 (FGE.65Rev1): Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of �Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14� evaluated by EFSA in FGE.13Rev2 (2011) View page or View pdf |
| Safety and efficacy of furfuryl and furan derivatives belonging to chemical group 14 when used as flavourings for all animal species and categories View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 13 Revision 3 (FGE.13Rev3): furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):28588-75-2 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :526624 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2-methyl-3-(2-methylfuran-3-yl)disulfanylfuran |
| Chemidplus:0028588752 |
| 2-methyl-3-(2-methylfuran-3-yl)disulfanylfuran | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 28588-75-2 |
| Pubchem (cid): | 526624 |
| Pubchem (sid): | 135264588 |
| Flavornet: | 28588-75-2 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB40201 |
| FooDB: | FDB019913 |
| YMDB (Yeast Metabolome Database): | YMDB01453 |
| Export Tariff Code: | 2932.19.0090 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| EFSA Update of results on the monitoring of furan levels in food: | Read Report |
| EFSA Previous report: Results on the monitoring of furan levels in food: | Read Report |
| EFSA Report of the CONTAM Panel on provisional findings on furan in food: | Read Report |
| 3,3'- | disulfanediylbis(2-methylfuran) |
| disulfide, bis(2-methyl-3-furyl) | |
| 3,3- | dithio-2,2-dimethyl difuran |
| 3,3'- | dithio-2,2'-dimethyldifuran |
| 3,3- | dithiobis(2-methyl furan) |
| 3,3'- | dithiobis(2-methyl furan) |
| 3,3'- | dithiobis[2-methylfuran] |
| furan, 3,3'-dithiobis[2-methyl- | |
| bis 2- | methyl 3 furyl disulfide 1% OS natural |
| bis (2- | methyl 3 furyl) disulfide |
| bis 2- | methyl 3-furyl disulphide |
| bis (2- | methyl 3-furyl) disulfide 1% in triethyl citrate natural |
| bis (2- | methyl 3-furyl) disulfide 10% in liponate natural |
| 2- | methyl-3-(2-methylfuran-3-yl)disulfanylfuran |
| bis-(2- | methyl-3-furan) disulphide |
| bis(2- | methyl-3-furanyl) disulfide |
| 2- | methyl-3-furyl disulfide |
| bis(2- | methyl-3-furyl disulfide) |
| bis (2 | methyl-3-furyl) disulfide |
| bis(2- | methyl-3-furyl) disulphide |
| bis(2- | methyl-3-furyl)disulfide |
| bis(2- | methyl-3-furyl)disulphide |
| 1,2-bis(2- | methylfuran-3-yl)disulfane |
| methylfuryl disulfide |
| None found yet. Try the PubMed Search. |
