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diisononyl phthalate

information only not used for fragrances or flavors
2D:
3D:
CAS Number: 28553-12-0
ECHA EC Number: 249-079-5
FDA UNII: 4010KIX4CK
Category: information only not used for fragrances or flavors
IUPAC Name: diisononyl phthalate
InChI : InChI=1/C26H42O4/c1-19(17-25(3,4)5)13-15-29-23(27)21-11-9-10-12-22(21)24(28)30-16-14-20(2)18-26(6,7)8/h9-12,19-20H,13-18H2,1-8H3
Std.InChI: InChI=1S/C26H42O4/c1-19(17-25(3,4)5)13-15-29-23(27)21-11-9-10-12-22(21)24(28)30-16-14-20(2)18-26(6,7)8/h9-12,19-20H,13-18H2,1-8H3
InChIKey : GDJOUZYAIHWDCA-UHFFFAOYAY
Std.InChIKey: GDJOUZYAIHWDCA-UHFFFAOYSA-N
SMILES : O=C(OCCC(C)CC(C)(C)C)c1ccccc1C(=O)OCCC(C)CC(C)(C)C
Molar Refractivity : 123.77 ± 0.3 cm3 (est)
Parachor : 1038.4 ± 4.0 cm3 (est)
Index of Refraction : 1.487 ± 0.02 (est)
Surface Tension : 33.9 ± 3.0 dyne/cm (est)
Density : 0.973 ± 0.06 g/cm3 (est)
Polarizability : 49.06 ± 0.5 10-24cm3 (est)

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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NCBI:Search
FDA Mainterm (IAUFC):28553-12-0 ; DIISONONYL PHTHALATE

Physical Properties:

Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: -48.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 463.35 °C. @ 760.00 mm Hg (est)
Vapor Pressure:5.400000 mmHg @ 25.00 °C. (est)
Flash Point: 419.00 °F. TCC ( 214.90 °C. ) (est)
logP (o/w): 9.026 (est)
Soluble in:
water, 0.2 mg/L @ 20 °C (exp)
water, 2.317e-005 mg/L @ 25 °C (est)

Cosmetic Information:

None found

Suppliers:

Covalent Chemical
Diisononyl Phthalate
HallStar
PLASTHALL® DINP
Odor: characteristic
Use: PLASTHALL DINP with its medium level of performance has found general use in applications that require permanence higher than what would be obtained through the use of DOP. PLASTHALL DINP has good efficiency properties, low volatility characteristics and good permanence in polar fluids. PLASTHALL DINP is replacing DOP where regulatory issues restrict the use of DOP as a general-purpose plasticizer.
Penta International
DIISONONYL PHTHALATE
Shiva Chemicals and Pharmaceuticals
Diisononyl Phthalate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Diisononyl phthalate ester content ≥99 % (mixture of C9 isomers), technical grade
Silver Fern Chemical
Diisononyl phthalate (DINP)
Odor: characteristic
Use: Diisononyl Phthalate is most commonly used to soften polyvinyl chloride (PVC), also known as vinyl, in the automobile, flooring and construction industries. It is a major component in determining the physical properties of vinyl products such as their durability, resistance to heat and cold and their flexibility. Common products using DINP are electric cables and synthetic leather, hoses for household appliances and wiring. Its extreme flexibility and low volatility make DINP a preferred choice in a wide range of indoor and outdoor applications.
SysKem Chemie
Di Isononyl Phthalate

Safety Information:

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
information only not used for fragrances or flavors
Recommendation for diisononyl phthalate usage levels up to:
not for fragrance use.
Recommendation for diisononyl phthalate flavor usage levels up to:
not for flavor use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Di-isononylphthalate (DINP) for use in food contact materials
View page or View pdf

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Di-isodecylphthalate (DIDP) for use in food contact materials
View page or View pdf

Technical report of the public consultation on the �Draft update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials�
View page or View pdf

Update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):28553-12-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :34277
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
bis(3,5,5-trimethylhexyl) benzene-1,2-dicarboxylate
Chemidplus:0014103618
EPA/NOAA CAMEO:hazardous materials
RTECS:28553-12-0

References:

bis(3,5,5-trimethylhexyl) benzene-1,2-dicarboxylate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:28553-12-0
Pubchem (cid):34277
Pubchem (sid):135051768

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•regular and electrical grades available from badische•commercially, diisononyl phthalate, dinp, is not a pure compound but rather a mixture of materials with an average side chain length of 9. ...•trade names: palatinol n, vestinol 9, jayflex dinp-s (production stopped in 1992). from table

Potential Blenders and core components :

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):

not found in nature

Synonyms:

baylectrol 4200
1,2-benzene dicarboxylic acid diisononyl ester
1,2-benzenedicarboxylic acid bis(3,5,5-trimethylhexyl) ester
1,2-benzenedicarboxylic acid, bis(3,5,5-trimethylhexyl) ester
1,2-benzenedicarboxylic acid, diisononyl ester
di-''isononyl'' phthalate
diisononylphthalate
DINP2
DINP3
JAY-DINP
jayflex DINP
palatinol DN
palatinol N
phthalic acid, diisononyl ester
phthalisocizer DINP
plasthall DINP
sansocizer DINP
bis(3,5,5-trimethylhexyl) phthalate
vestinol 9
vestinol NN
vinylcizer 90
witamol 150

Articles:

PubMed:Generation of hazard indices for cumulative exposure to phthalates for use in cumulative risk assessment.
PubMed:Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin.
PubMed:Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures.
PubMed:Dispersive solid-phase extraction based on magnetic dummy molecularly imprinted microspheres for selective screening of phthalates in plastic bottled beverages.
PubMed:Semivolatile organic compounds in indoor air and settled dust in 30 French dwellings.
PubMed:Associations between serum phthalates and biomarkers of reproductive function in 589 adult men.
PubMed:Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice.
PubMed:Ecological risk assessment of chemicals migrated from a recycled plastic product.
PubMed:Emissions of two phthalate esters and BDE 209 to indoor air and their impact on urban air quality.
PubMed:[The occurrence of plasticisers (phthalates) in communal facilities under special consideration of results from LUPE 3].
PubMed:Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP).
PubMed:Adverse effects of diisooctyl phthalate on the male rat reproductive development following prenatal exposure.
PubMed:[Hazardous endocrine disruptors. Phthalates in our hospital].
PubMed:Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000-2012).
PubMed:Analysis of selected phthalates in Canadian indoor dust collected using household vacuum and standardized sampling techniques.
PubMed:Determination of phthalate diesters in foods.
PubMed:[Toxicity effects of phthalate substitute plasticizers used in toys].
PubMed:[Determination of phthalic acid esters in imitation jewellery and investigation of their migration risk].
PubMed:Urinary biomarkers for phthalates associated with asthma in Norwegian children.
PubMed:A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.
PubMed:Plasticizer incident and its health effects in Taiwan.
PubMed:Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men.
PubMed:Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats.
PubMed:Effects of 4-nonylphenol and/or diisononylphthalate on THP-1 cells: impact of endocrine disruptors on human immune system parameters.
PubMed:[Determination of 23 phthalate esters in food by solid-phase extraction coupled with gas chromatography-mass spectrometry].
PubMed:Dummy molecularly imprinted solid-phase extraction for selective determination of five phthalate esters in plastic bottled functional beverages.
PubMed:Human biological monitoring of diisononyl phthalate and diisodecyl phthalate: a review.
PubMed:[Survey of plasticizers in polyvinyl chloride toys].
PubMed:High urinary phthalate concentration associated with delayed pubarche in girls.
PubMed:Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: temporal trends and timing of amniocentesis in pregnancy.
PubMed:Endocrine disruptors and asthma-associated chemicals in consumer products.
PubMed:A comprehensive review of intake estimates of di-isononyl phthalate (DINP) based on indirect exposure models and urinary biomonitoring data.
PubMed:[Test method for 6 phthalates in polyvinyl chloride].
PubMed:Identification of di-isononyl phthalate metabolites for exposure marker discovery using in vitro/in vivo metabolism and signal mining strategy with LC-MS data.
PubMed:Beyond phthalates: gas phase concentrations and modeled gas/particle distribution of modern plasticizers.
PubMed:Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan.
PubMed:Phthalate exposure during cold plastisol application--a human biomonitoring study.
PubMed:Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations.
PubMed:Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate.
PubMed:Biomonitoring equivalents for di-isononyl phthalate (DINP).
PubMed:Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats.
PubMed:Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey.
PubMed:Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth.
PubMed:Determination of five phthalate monoesters in human urine using gas chromatography-mass spectrometry.
PubMed:Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro.
PubMed:Determination of phthalates in diet and bedding for experimental animals using gas chromatography-mass spectrometry.
PubMed:Rapid and nondestructive analysis of phthalic acid esters in toys made of poly(vinyl chloride) by direct analysis in real time single-quadrupole mass spectrometry.
PubMed:Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland.
PubMed:Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions.
PubMed:Phthalates and nonylphenols in urban runoff: Occurrence, distribution and area emission factors.
PubMed:P450(BM-3)-catalyzed whole-cell biotransformation of alpha-pinene with recombinant Escherichia coli in an aqueous-organic two-phase system.
PubMed:Hazard to the developing male reproductive system from cumulative exposure to phthalate esters--dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate.
PubMed:Biodegradation of a phthalate plasticizer, di-isononyl phthalate (DINP), by Sphingobium chungbukense.
PubMed:Phthalates: metabolism and exposure.
PubMed:Metabolism of phthalates in humans.
PubMed:Urinary metabolites of diisodecyl phthalate in rats.
PubMed:Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP.
PubMed:[Determination of phthalic acid esters in textiles by solid phase extraction-gas chromatography].
PubMed:[Survey of epoxidized soybean oil in cap sealing for bottled foods].
PubMed:Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment.
PubMed:Urinary biomarkers of di-isononyl phthalate in rats.
PubMed:Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats.
PubMed:Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment.
PubMed:Modulation of iodide uptake by dialkyl phthalate plasticisers in FRTL-5 rat thyroid follicular cells.
PubMed:Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring.
PubMed:Hazard evaluation of diisononyl phthalate and diisodecyl phthalate in a Japanese medaka multigenerational assay.
PubMed:Risk assessment of oral exposure to diisononyl phthalate from children's products.
PubMed:Enhancement of interleukin-4 production in activated CD4+ T cells by diphthalate plasticizers via increased NF-AT binding activity.
PubMed:Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats.
PubMed:Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals.
PubMed:Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life.
PubMed:[Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products].
PubMed:Role of the peroxisome proliferator-activated receptor alpha in responses to diisononyl phthalate.
PubMed:[Estimation of daily oral exposure to phthalates derived from soft polyvinyl chloride baby toys].
PubMed:Determination of phthalate ester congeners and mixtures by LC/ESI-MS in sediments and biota of an urbanized marine inlet.
PubMed:Pediatric exposure and potential toxicity of phthalate plasticizers.
PubMed:Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan.
PubMed:A simple and reproducible testing method for dialkyl phthalate migration from polyvinyl chloride products into saliva simulant.
PubMed:[Contents of plasticizers in cap-sealing for bottled food and their migration into food].
PubMed:Adjuvant effect of di-n-butyl-, di-n-octyl-, di-iso-nonyl- and di-iso-decyl phthalate in a subcutaneous injection model using BALB/c mice.
PubMed:Gas chromatography-mass spectrometry determination of the migration of phthalate plasticisers from polyvinyl chloride toys and childcare articles.
PubMed:Comments on Foster, P., and McIntyre, B. (2002). Endocrine active agents: implications of adverse and non-adverse changes. Toxicol Pathol 30(1): 59-65.
PubMed:Tumor induction in mouse liver: di-isononyl phthalate acts via peroxisome proliferation.
PubMed:NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate.
PubMed:Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats.
PubMed:Species differences in response to the phthalate plasticizer monoisononylphthalate (MINP) in vitro: a comparison of rat and human hepatocytes.
PubMed:Migration of phthalates from PVC toys into saliva simulant by dynamic extraction.
PubMed:An assessment of the toxicity of phthalate esters to freshwater benthos. 2. Sediment exposures.
PubMed:[Contents of eleven phthalates and di(2-ethylhexyl) adipate in retail packed lunches after prohibition of DEHP-containing PVC gloves for cooking purposes].
PubMed:[Contents of phthalate in polyvinyl chloride toys].
PubMed:Analysis of plasticizers in cap-sealing resins for bottled foods.
PubMed:Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate (DIDP) are not mutagenic.
PubMed:Response letter from ACSH phthalate panel.
PubMed:Letter in response to ACSH report on plasticizers.
PubMed:Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat.
PubMed:The role of inhibition of gap junctional intercellular communication in rodent liver tumor induction by phthalates: review of data on selected phthalates and the potential relevance to man.
PubMed:Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys.
PubMed:Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver.
PubMed:Concentrations of phthalate esters and identification of other additives in PVC children's toys.
PubMed:Two-generation reproduction study in rats given di-isononyl phthalate in the diet.
PubMed:Suppression of apoptosis and induction of DNA synthesis in vitro by the phthalate plasticizers monoethylhexylphthalate (MEHP) and diisononylphthalate (DINP): a comparison of rat and human hepatocytes in vitro.
PubMed:The potential health effects of phthalate esters in children's toys: a review and risk assessment.
PubMed:Retrospective evaluation of alpha 2u-globulin accumulation in male rat kidneys following high doses of diisononyl phthalate.
PubMed:Effects of di-isononyl phthalate (DINP) on peroxisomal markers in the marmoset-DINP is not a peroxisome proliferator.
PubMed:Developmental toxicity of di-isodecyl and di-isononyl phthalates in rats.
PubMed:Analysis of potentially toxic phthalate plasticizers used in toy manufacturing.
PubMed:Differential prenatal toxicity of branched phthalate esters in rats.
PubMed:Biodegradation of DEHP, DBP, and DINP: poorly water soluble and widely used phthalate plasticizers.
PubMed:Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats.
PubMed:Sqwish Ball dermatitis.
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