| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 25013-16-5 |
| ECHA EC Number: | 246-563-8 |
| FDA UNII: | REK4960K2U |
| Category: | antioxidants and preservatives for fragrance and flavor |
| IUPAC Name: | butylated hydroxyanisole |
| InChI : | InChI=1S/2C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12;1-11(2,3)9-7-8(12)5-6-10(9)13-4/h2*5-7,12H,1-4H3 |
| Std.InChI: | InChI=1S/2C11H16O2/c1-11(2,3)9-7-8(13-4)5-6-10(9)12;1-11(2,3)9-7-8(12)5-6-10(9)13-4/h2*5-7,12H,1-4H3 |
| InChIKey : | CZBZUDVBLSSABA-UHFFFAOYAZ |
| Std.InChIKey: | CZBZUDVBLSSABA-UHFFFAOYSA-N |
| SMILES : | CC(C)(C)C1=C(C=CC(=C1)O)OC.CC(C)(C)C1=C(C=CC(=C1)OC)O |
| MDL: | MFCD01779059 |
| Molar Refractivity : | 53.20 ± 0.3 cm3 (est) |
| Parachor : | 426.9 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.507 ± 0.02 (est) |
| Surface Tension : | 32.7 ± 3.0 dyne/cm (est) |
| Density : | 1.009 ± 0.06 g/cm3 (est) |
| Polarizability : | 21.09 ± 0.5 10-24cm3 (est) |
| Appearance: | white to pale yellow solid (est) |
| Assay: | 98.00 to 100.00 |
| Food Chemicals Codex Listed: | Yes |
| Melting Point: | 58.00 to 60.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 268.00 to 269.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.004000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 6.2 ( Air = 1 ) |
| Flash Point: | 235.00 °F. TCC ( 112.78 °C. ) |
| logP (o/w): | 3.087 (est) |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: | |
| alcohol | |
| water, 212.8 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | antioxidants fragrance |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 40 - Possible risks of irreversable effects. S 02 - Keep out of the reach of children. S 22 - Do not breath dust. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 2000 mg/kg BEHAVIORAL: ATAXIABEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 22, Pg. 231, 1970. intraperitoneal-rat LD50 881 mg/kg BLOOD: HEMORRHAGE Toxicology Letters. Vol. 27, Pg. 15, 1985. oral-mouse LD50 1100 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATIONBEHAVIORAL: ATAXIABEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 22, Pg. 231, 1970. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| antioxidants and preservatives for fragrance and flavor | |||
| Recommendation for butylated hydroxyanisole usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 2.80000 | |
| beverages(nonalcoholic): | - | 0.82000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | 13.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | 230.00000 | |
| fish products: | - | - | |
| frozen dairy: | - | 0.81000 | |
| fruit ices: | - | 0.81000 | |
| gelatins / puddings: | - | 0.54000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 9.60000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | 5.00000 | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Authority (EFSA) reference(s): |
| Scientific Opinion on the re-evaluation of butylated hydroxyanisole � BHA (E 320) as a food additive View page or View pdf |
| Statement on the safety assessment of the exposure to butylated hydroxyanisole E 320 (BHA) by applying a new exposure assessment methodology View page or View pdf |
| Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species View page or View pdf |
| Safety of butylated hydroxy anisole (BHA) for all animal species View page or View pdf |
| Safety and efficacy of a feed additive consisting of butylated hydroxyanisole (BHA) for use in cats (FEDIAF) View page or View pdf |
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):25013-16-5 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :24667 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| 2-tert-butyl-4-methoxyphenol;3-tert-butyl-4-methoxyphenol |
| Chemidplus:0025013165 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:SL1945000 for cas# 25013-16-5 |
| 2-tert-butyl-4-methoxyphenol;3-tert-butyl-4-methoxyphenol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 25013-16-5 |
| Pubchem (cid): | 24667 |
| Pubchem (sid): | 134996929 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C15469 |
| HMDB (The Human Metabolome Database): | HMDB31848 |
| FooDB: | FDB008532 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •the commercial prepn of bha sold under name of tenox bha (eastman chem inc) contains about 85% of 3-tert-butyl-4-hydroxyanisole & 15% of 2-tert-butyl-4-hydroxyanisole.•food grade, 98.5+%. | |
| None Found |
| antioxidants | |
| preservatives |
| not found in nature |
| antioxyne B | |
| B.H.A. | |
| BHA | |
| BHA food grade NF | |
| butyl hydroxyanisole | |
| tert- | butyl hydroxyanisole |
| 2(3)-t- | butyl-4-hydroxyanisole |
| 2(3)-tert- | butyl-4-hydroxyanisole |
| tert- | butyl-4-hydroxyanisole |
| 2(3)-tert- | butyl-4-methoxyphenol |
| tert- | butyl-4-methoxyphenol |
| 2-tert- | butyl-4-methoxyphenol;3-tert-butyl-4-methoxyphenol |
| 3-tert- | butyl-4-methoxyphenyl and 2tert-butyl-4-methoxyphenol |
| 2-tert- | butyl-4-methoxyphenyl and 3-tert-butyl-4-methoxyphenol |
| 2(3)-(tert- | butyl)-4-methoxyphenol |
| tert- | butylhydroxyanisole |
| (1,1- | dimethyl ethyl)-4-methoxyphenol |
| 2(3)-(1,1- | dimethylethyl)-4-(methyloxy)phenol |
| 2(3)-(1,1- | dimethylethyl)-4-methoxy-phenol |
| 2(or 3)-(1,1- | dimethylethyl)-4-methoxyphenol |
| embanox | |
| butylated | hydroxy anisole (BHA) EP/NF powder (40 mesh) |
| butylated | hydroxy anisole (BHA) NF / FCC grade |
| butylated | hydroxy anisole EP grade |
| 4- | hydroxy-2(3)-tert-butylanisole |
| butylated | hydroxyanisole (BHA) EP / IP grade |
| butylated | hydroxyanisole (BHA) EP / NF grade |
| butylated | hydroxyanisole (BHA) FCC |
| butylated | hydroxyanisole (BHA) N.F. |
| butylated | hydroxyanisole (BHA) NF/FCC powder (40 mesh) |
| 4- | methoxy-2(3)-tert-butylphenol |
| phenol, (1,1-dimethylethyl)-4-methoxy- | |
| phenol, 2(3)-(1,1-dimethylethyl)-4-methoxy- | |
| phenol, 2(3)-t-butyl-4-methoxy- | |
| phenol, 2(3)-tert-butyl-4-methoxy- | |
| phenol, t-butyl-4-methoxy- | |
| tenox BHA food grade antioxidant, flake |
