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glutaconic acid

information only not used for fragrances or flavors
2D:
3D:
CAS Number: 1724-02-3
ECHA EC Number: 217-027-0
FDA UNII: NOH8K33D47
Category: information only not used for fragrances or flavors
IUPAC Name: glutaconic acid
InChI : InChI=1/C5H6O4/c6-4(7)2-1-3-5(8)9/h1-2H,3H2,(H,6,7)(H,8,9)/b2-1+
Std.InChI: InChI=1S/C5H6O4/c6-4(7)2-1-3-5(8)9/h1-2H,3H2,(H,6,7)(H,8,9)/b2-1+
InChIKey : XVOUMQNXTGKGMA-OWOJBTEDBR
Std.InChIKey: XVOUMQNXTGKGMA-OWOJBTEDSA-N
SMILES : C(/C=C/C(=O)O)C(=O)O
MDL: MFCD00002784
Molar Refractivity : 28.40 ± 0.3 cm3 (est)
Parachor : 261.8 ± 4.0 cm3 (est)
Index of Refraction : 1.516 ± 0.02 (est)
Surface Tension : 60.4 ± 3.0 dyne/cm (est)
Density : 1.384 ± 0.06 g/cm3 (est)
Polarizability : 11.25 ± 0.5 10-24cm3 (est)

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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PubMed:Search
NCBI:Search

Physical Properties:

Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 413.80 °C. @ 760.00 mm Hg (est)
Flash Point: 425.00 °F. TCC ( 218.20 °C. ) (est)
logP (o/w): 0.040 (est)
Soluble in:
water, 5.842e+005 mg/L @ 25 °C (est)

Cosmetic Information:

None found

Suppliers:

BOC Sciences
For experimental / research use only.
Glutaconic acid 98%
Santa Cruz Biotechnology
For experimental / research use only.
Glutaconic Acid
Sigma-Aldrich: Aldrich
For experimental / research use only.
Glutaconic Acid ≥97.0% (T)

Safety Information:

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
information only not used for fragrances or flavors
Recommendation for glutaconic acid usage levels up to:
not for fragrance use.
Recommendation for glutaconic acid flavor usage levels up to:
not for flavor use.

Safety References:

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280498
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(E)-pent-2-enedioic acid
Chemidplus:0001724023

References:

(E)-pent-2-enedioic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5280498
Pubchem (sid):172648256

Other Information:

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C02214
HMDB (The Human Metabolome Database):HMDB00620
FooDB:FDB022146
ChemSpider:View
Wikipedia:View

Potential Blenders and core components :

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):

not found in nature

Synonyms:

trans-glutaconate
(E)-glutaconic acid
pent-2-ene-1,5-dioic acid
(2E)-pent-2-enedioic acid
(E)-pent-2-enedioic acid
2-pentene dioic acid
(2E)-2-pentenedioic acid
2-pentenedioic acid, (2E)-

Articles:

PubMed:One-pot formation of 2,4-di- or 2,4,6-tri-olefinic monocarboxylic acids by straight chain C4-extension.
PubMed:Experimental Evidence of Long-Range Intramolecular Vibrational Energy Redistribution through Eight Covalent Bonds: NIR Irradiation Induced Conformational Transformation of E-Glutaconic Acid.
PubMed:Favourable Outcome in Two Pregnancies in a Patient with 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency.
PubMed:Metabolic changes in rat serum after administration of suberoylanilide hydroxamic acid and discriminated by SVM.
PubMed:Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision.
PubMed:An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis.
PubMed:Clinical and molecular investigation in Chinese patients with glutaric aciduria type I.
PubMed:Base-catalyzed bicyclization of dialkyl glutaconates with cinnamoylacetamides: a synthetic strategy for isoquinolinedione derivatives.
PubMed:Diagnosis by whole exome sequencing of atypical infantile onset Alexander disease masquerading as a mitochondrial disorder.
PubMed:Catalytic asymmetric Tamura cycloadditions.
PubMed:Brain MRI findings as an important diagnostic clue in glutaric aciduria type 1.
PubMed:Neurotoxic effects of trans-glutaconic acid in rats.
PubMed:Diagnosis and management of glutaric aciduria type I--revised recommendations.
PubMed:Production of glutaconic acid in a recombinant Escherichia coli strain.
PubMed:Effects of structural analogues of the substrate and allosteric regulator of the human mitochondrial NAD(P)+-dependent malic enzyme.
PubMed:Efficient synthesis and neuroprotective effect of substituted 1,3-diphenyl-2-propen-1-ones.
PubMed:Guideline for the diagnosis and management of glutaryl-CoA dehydrogenase deficiency (glutaric aciduria type I).
PubMed:Basidiochrome -- a novel siderophore of the Orchidaceous Mycorrhizal Fungi Ceratobasidium and Rhizoctonia spp.
PubMed:Glutaric acid and its metabolites cause apoptosis in immature oligodendrocytes: a novel mechanism of white matter degeneration in glutaryl-CoA dehydrogenase deficiency.
PubMed:Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I.
PubMed:99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Nalpha-His)acetic acid-modified [D-Glu1]-minigastrin.
PubMed:3-Hydroxyglutaric acid fails to affect the viability of primary neuronal rat cells.
PubMed:[Glutaric aciduria type 1: an example of the importance of early detection of so-called cerebral organic aciduria].
PubMed:On the neurotoxicity of glutaric, 3-hydroxyglutaric, and trans-glutaconic acids in glutaric acidemia type 1.
PubMed:Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction.
PubMed:Hydrogen-bonded complexes of 2-pyridone with centrosymmetric and non-centrosymmetric dicarboxylic acids.
PubMed:Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids.
PubMed:Sensitivity and specificity of free and total glutaric acid and 3-hydroxyglutaric acid measurements by stable-isotope dilution assays for the diagnosis of glutaric aciduria type I.
PubMed:3-Methyl glutaconic aciduria in Iraqi Jewish children may be misdiagnosed as cerebral palsy.
PubMed:Nerve cell lesions caused by 3-hydroxyglutaric acid: a possible mechanism for neurodegeneration in glutaric acidaemia I.
PubMed:Subdural hemorrhage as an initial sign of glutaric aciduria type 1: a diagnostic pitfall.
PubMed:Sodium ion-dependent hydrogen production in Acidaminococcus fermentans.
PubMed:Chronic subdural hematoma, as an initial manifestation of glutaric aciduria type-1.
PubMed:Organic acid and acylcarnitine profiles of glutaric aciduria type I.
PubMed:A biotin-dependent sodium pump: glutaconyl-CoA decarboxylase from Acidaminococcus fermentans.
PubMed:3-hydroxy-3-methylglutaryl-CoA lyase deficiency in an infant with macrocephaly and mild metabolic acidosis.
PubMed:The identification of (E)-2-methylglutaconic acid, a new isoleucine metabolite, in the urine of patients with beta-ketothiolase deficiency, propionic acidaemia and methylmalonic acidaemia.
PubMed:Glutaconate CoA-transferase from Acidaminococcus fermentans.
PubMed:The reversible dehydration of (R)-2-hydroxyglutarate to (E)-glutaconate.
PubMed:Glutaric aciduria: clinical and laboratory findings in two brothers.
PubMed:Glutaconic acid, a product of the fermentation of glutamic acid by Peptococcus aerogenes.
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