| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 111-30-8 |
| ECHA EC Number: | 203-856-5 |
| FDA UNII: | T3C89M417N |
| Category: | antioxidants and preservatives for fragrance and flavor |
| IUPAC Name: | glutaric dialdehyde 50% in water |
| InChI : | InChI=1/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2 |
| Std.InChI: | InChI=1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2 |
| InChIKey : | SXRSQZLOMIGNAQ-UHFFFAOYAO |
| Std.InChIKey: | SXRSQZLOMIGNAQ-UHFFFAOYSA-N |
| SMILES : | C(CC=O)CC=O |
| MDL: | MFCD00007025 |
| Molar Refractivity : | 25.58 ± 0.3 cm3 (est) |
| Parachor : | 248.8 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.399 ± 0.02 (est) |
| Surface Tension : | 30.7 ± 3.0 dyne/cm (est) |
| Density : | 0.947 ± 0.06 g/cm3 (est) |
| Polarizability : | 10.14 ± 0.5 10-24cm3 (est) |
| Appearance: | colorless clear liquid (est) |
| Assay: | 95.00 to 100.00 |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 1.00500 to 1.01100 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 8.363 to 8.413 |
| Refractive Index: | 1.43000 to 1.43600 @ 20.00 °C. |
| Boiling Point: | 188.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.600000 mmHg @ 30.00 °C. |
| Flash Point: | > 300.00 °F. TCC ( > 148.89 °C. ) |
| logP (o/w): | -0.180 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | store under nitrogen. |
| Storage: | refrigerate in tightly sealed containers. store under nitrogen. |
| Soluble in: | |
| alcohol | |
| water, 1.672e+005 mg/L @ 25 °C (est) | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | preservatives |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| T N - Toxic, Dangerous for the environment. | |
| R 23/25 - Toxic by inhalation and if swallowed. R 34 - Causes burns. R 42/43 - May cause sensitization by inhalation and skin contact. R 50 - Very toxic to aquatic organisms. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 23 - Do not breath fumes. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. S 45 - In case of accident or if you feel unwell seek medical advice immediately. S 61 - Avoid release to the environment. Refer to special instructions/safety data sheet. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| gavage-rat LD50 252 mg/kg (Stonehill et al., 1963) gavage-rat LD50 [sex: M] 733 mg/kg (Ballantyne & Myers, 2001) gavage-rat LD50 [sex: M] 2380 mg/kg (Smyth et al., 1962) gavage-rat LD50 [sex: M] 540 mg/kg (Striegel & Carpenter, 1964) oral-rat LD50 [sex: M] 134 mg/kg (Ikeda, 1980) oral-rat LD50 [sex: F] 165 mg/kg (Ikeda, 1980) gavage-rat LD50 [sex: M] 1300 mg/kg (Myers et al., 1977b) gavage-rat LD50 [sex: M] 1870 mg/kg (Myers et al., 1977c) gavage-mouse LD50 352 mg/kg (Stonehill et al., 1963) oral-mouse LD50 [sex: M] 100 mg/kg (Ikeda, 1980) oral-mouse LD50 [sex: F] 110 mg/kg (Ikeda, 1980) gavage-mouse LD50 [sex: M] 152 mg/kg (Ballantyne & Myers, 2001) gavage-mouse LD50 [sex: F] 113 mg/kg (Ballantyne & Myers, 2001) gavage-mouse LD50 [sex: M] 151 mg/kg (Union Carbide Corp., 1992) gavage-mouse LD50 [sex: F] 115 mg/kg (Union Carbide Corp., 1992) oral-guinea pig LD50 50 mg/kg (Union Carbide Corp., 1992) oral-duck LD50 820 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: FOOD INTAKE (ANIMAL) National Technical Information Service. Vol. OTS0526410-1 oral-guinea pig LD50 50 mg/kg BEHAVIORAL: EXCITEMENTBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(3), Pg. 77, 1987. intraperitoneal-mouse LD50 13900 ug/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. intravenous-mouse LD50 15400 ug/kg Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. oral-mouse LD50 100 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. intraperitoneal-rat LD50 17900 ug/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 232, 1979. intravenous-rat LD50 9800 ug/kg United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1290-1008 oral-rat LD50 134 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 560 ul/kg Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. subcutaneous-rat LD50 > 750 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. skin-rat LD50 > 2500 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. skin-mouse LD50 > 5840 mg/kg Oyo Yakuri. Pharmacometrics. Vol. 19, Pg. 503, 1980. skin-mouse LD50 > 5840 mg/kg SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 11, 1976. subcutaneous-mouse LD50 > 590 mg/kg Drugs in Japan Vol. -, Pg. 395, 1995. skin-rabbit LD50 560 uL/kg Union Carbide Data Sheet. Vol. 11/4/1971 skin-rat LD50 > 2500 mg/kg SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Oyo Yakuri. Pharmacometrics. Vol. 12, Pg. 11, 1976. subcutaneous-rat LD50 > 750 mg/kg Drugs in Japan Vol. -, Pg. 395, 1995. | |
| Inhalation Toxicity: | |
| inhalation-rat LC50 480 mg/m3/4H Drugs in Japan Vol. -, Pg. 395, 1995. inhalation-rat LC50 480 mg/m3/4H United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1290-1008 | |
| Category: | |||
| antioxidants and preservatives for fragrance and flavor | |||
| Recommendation for glutaric dialdehyde 50% in water usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.055 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | I (μg/capita/day) | ||
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 1600 (μg/person/day) | ||
| Threshold of Concern: | 1800 (μg/person/day) | ||
| Structure Class: | I | ||
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). | |||
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. | |||
| average usage mg/kg | maximum usage mg/kg | ||
| Dairy products, excluding products of category 02.0 (01.0): | 3.00000 | 15.00000 | |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 2.00000 | 10.00000 | |
| Edible ices, including sherbet and sorbet (03.0): | 3.00000 | 15.00000 | |
| Processed fruit (04.1): | 2.00000 | 10.00000 | |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - | |
| Confectionery (05.0): | 4.00000 | 20.00000 | |
| Chewing gum (05.3): | - | - | |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 2.00000 | 10.00000 | |
| Bakery wares (07.0): | 5.00000 | 25.00000 | |
| Meat and meat products, including poultry and game (08.0): | 1.00000 | 5.00000 | |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 1.00000 | 5.00000 | |
| Eggs and egg products (10.0): | - | - | |
| Sweeteners, including honey (11.0): | - | - | |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 2.00000 | 10.00000 | |
| Foodstuffs intended for particular nutritional uses (13.0): | 3.00000 | 15.00000 | |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 2.00000 | 10.00000 | |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 4.00000 | 20.00000 | |
| Ready-to-eat savouries (15.0): | 5.00000 | 25.00000 | |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 2.00000 | 10.00000 | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 View page or View pdf |
| EPI System: View |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
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| Toxicology Citations:Search |
| Carcinogenic Potency Database:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):111-30-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :3485 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| pentanedial |
| Chemidplus:0000111308 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:111-30-8 |
| pentanedial | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 111-30-8 |
| Pubchem (cid): | 3485 |
| Pubchem (sid): | 134975016 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C12518 |
| HMDB (The Human Metabolome Database): | HMDB29599 |
| FooDB: | FDB000763 |
| Export Tariff Code: | 2912.19.5000 |
| FDA Listing of Food Additive Status: | View |
| Wikipedia: | View |
| Formulations/Preparations: •usepaopp pesticide code 043901; trade names: cidex, component of; odix, component of; aldesan; alhydex; glutaralum; hospex; nci-c55425; sonacide; coldcide-25 microbiocide concentrate; gkn-o microbiocide concentrate (043901+069104+069154).•soluble concentrates, ready-to-use solutions, impregnated materials, water soluble packages, and microencapsulated preparations (medical waste). glutaraldehyde is not available as a neat, undiluted chemical. however, it is commercially available as 4%, 15%, 25%, 45%, and 50% (vv) aqueous solutions.•it has been marketed as 2% alkaline soln in 70% isopropanol...•cidex (arbrook) topical: soln (aq) 2%.•grades: 99%; 50% biological solution; 25% solution.•employed as 25% soln in water for embalming fluid.•2% aq soln buffered with 0.3% sodium carbonate to ph of 7.5-8.5 is useful for disinfection and sterilization of endoscopic instruments & plastic & rubber apparatus used for inhalation therapy & anesthesia.•usually sold commercially as a 45% or 50% aqueous solution.•electron microscopy grade is highly purified•biocide; supplied in acid solution and subsequently buffered to ph 8•a-215 (ecolab) glutaral 15%•a-245 (ecolab) glutaral 45%•ama-1500g (kemira chemicals) glutaral 15%•ama-2500g (kemira chemicals) glutaral 25%•ama-5000g (kemira chemicals) glutaral 50%•aqucar ga 23 sb water treatment microbicide (dow chemical) glutaral 23%•aqucar ga 30lt water treatment microbicide (dow chemical) glutaral 30%•aqucar 504 water treatment microbicide (dow chemical) glutaral 4%•bactron k-31 microbicide (champion technologies) glutaral 25%•bactron k-86 microbicide (champion technologies) glutaral 43.3%, alkyl dimethyl benzyl ammonium chloride 3.5%, alkyl dimethyl ethylbenzyl ammonium chloride 3.5%•busan 1202 (buckman laboratories) glutaral 50%•coldcide 0.25% (colcide) glutaral 0.275%, 4-ter-amylphenol 0.0027%, o-phenylphenol 0.0137%•diald 15 (buckman laboratories) glutaral 15%•diald 25 (buckman laboratories) glutaral 25%•diald 45 (buckman laboratories) glutaral 45%•diald 50 (buckman laboratories) glutaral 50%•gkn-o (champion technologies) glutaral 25.75%, alkyl dimethyl benzyl ammonium chloride 6.25%, alkyl dimethyl ethylbenzyl ammonium chloride 6.25%•glutex gq1 sanitizer and disinfectant (dow chemical) glutaral 14%, alkyl dimethyl benzyl ammonium chloride 2.5%•maquat 25:12 (mason chemical) glutaral 25.7 %, alkyl dimethyl benzyl ammonium chloride 5%, alkyl dimethyl benzyl ammonium chloride 7.5%•myacide ga 15 (basf) glutaral 15%•myacide ga 25 (basf) glutaral 25%•myacide ga 45 (basf) glutaral 45%•myacide ga 50 (basf) glutaral 50%•myacide gda technical (basf) glutaral 50%•n-5033 antimicrobial (verichem) glutaral 50%•owt-908 microbicide (nch) glutaral 25.75%, alkyl dimethyl ethylbenzyl ammonium chloride 6.25%, n-alkyl dimethyl benzyl ammonium chlorides 6.25%•piror 842 slimicide (dow chemical) glutaral 42.5%, alkyl dimethyl benzyl ammonium chloride 7.5%•premicide (metrex research) glutaral 9.61%•sanisorbx (multisorb technologies) glutaral 9.6%•spectrus nx1105 (ge betz) glutaral 45%•sporicidin-hd concentrated for hemodialysis (contec) glutaral 13%, phenol 7.05%, sodium phenate 1.2%•ster-cid (mcm environmental technologies) glutaral 10.72%, alkyl dimethyl benzyl ammonium chloride 17.06%, didecyl dimethyl ammonium chloride 7.8%•surcide g-50 (surety laboratories) glutaral 50%•ucarsan sanitizer 4128 (dow chemical) 12.8%•ucarsan sanitizer 420 (dow chemical) glutaral 20%•ucarcide 25 (dow chemical) glutaral 25%•ucarcide 15 antimicrobial (dow chemical) glutaral 15%•ucarcide 42 antimicrobial (dow chemical) glutaral 42.5%, alkyl dimethyl benzyl ammonium chloride 7.5%•ucarcide 45 antimicrobial (dow chemical) glutaral 45%•ucarcide 225 antimicrobial (dow chemical) glutaral 25%•ucarcide 250 antimicrobial (dow chemical) glutaral 50%•virocid (cid lines n.v.) glutaral 10.725%, alkyl dimethyl benzyl ammonium chloride 17.06%, didecyl dimethyl ammonium chloride 7.8%•wavicide-06 plus (medical chemical corp) ethyl alcohol 50%, glutaral 0.25%•x-cide 102 industrial bactericide (baker petrolite corp) glutaral 25%•x-cide 105 (baker petrolite corp) glutaral 50%•x-cide 107 industrial bactericide (baker petrolite corp.) glutaral 20%•glutarol 10% glutaraldehyde wv cutaneous solution (dermal laboratories limited, uk). | |
| None Found |
| preservatives |
| not found in nature |
| cidex | |
| 1,3- | diformyl propane |
| 1,3- | diformylpropane |
| glutaral | |
| glutaraldehyde | |
| glutaraldehyde aqueous solution, 25% | |
| pentane dial | |
| 1,5- | pentane dial |
| 1,5- | pentane dione |
| pentanedial | |
| 1,5- | pentanedial |
| sonacide |
