| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 110-17-8 |
| ECHA EC Number: | 203-743-0 |
| FDA UNII: | 88XHZ13131 |
| CoE Number: | 25 |
| Category: | special dietary and nutritional additives |
| IUPAC Name: | fumaric acid |
| InChI : | InChI=1/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+ |
| Std.InChI: | InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+ |
| InChIKey : | VZCYOOQTPOCHFL-OWOJBTEDBF |
| Std.InChIKey: | VZCYOOQTPOCHFL-OWOJBTEDSA-N |
| SMILES : | C(=C/C(=O)O)\C(=O)O |
| MDL: | MFCD00002700 |
| Molar Refractivity : | 23.76 ± 0.3 cm3 (est) |
| Parachor : | 222.0 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.526 ± 0.02 (est) |
| Surface Tension : | 67.6 ± 3.0 dyne/cm (est) |
| Density : | 1.499 ± 0.06 g/cm3 (est) |
| Polarizability : | 9.42 ± 0.5 10-24cm3 (est) |
| Appearance: | white colorless crystalline powder (est) |
| Assay: | 99.00 to 100.00 |
| Food Chemicals Codex Listed: | Yes |
| Melting Point: | 298.00 to 300.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 156.00 °C. @ 1.70 mm Hg |
| Vapor Pressure: | 0.000005 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. ) |
| logP (o/w): | 0.460 |
| Soluble in: | |
| alcohol | |
| oils, slightly | |
| water, 1.042e+005 mg/L @ 25 °C (est) | |
| water, 7000 mg/L @ 25 °C (exp) | |
| CosIng: | cosmetic data |
| Cosmetic Uses: | buffering agents |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
| R 36 - Irritating to eyes. S 02 - Keep out of the reach of children. S 25 - Avoid contact with eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 39 - Wear eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 [sex: F] 9300 mg/kg (Vernot et al., 1977) oral-rat LD50 [sex: M] 10700 mg/kg (Vernot et al., 1977) oral-rabbit LDLo 5000 mg/kg Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923. intraperitoneal-mouse LD50 100 mg/kg National Technical Information Service. Vol. AD277-689 oral-rabbit LDLo 5000 mg/kg Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923. oral-rat LD50 9300 mg/kg Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977. intraperitoneal-rat LDLo 587 mg/kg LIVER: OTHER CHANGESGASTROINTESTINAL: OTHER CHANGESBLOOD: HEMORRHAGE Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 298, 1946. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| special dietary and nutritional additives | |||
| Recommendation for fumaric acid usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 780.00 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 1300.00000 | |
| beverages(nonalcoholic): | - | 50.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | 3600.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
| Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab) View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009) View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 View page or View pdf |
| Scientific Opinion on the safety and efficacy of fumaric acid as a feed additive for all animal species View page or View pdf |
| Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy View page or View pdf |
| Safety and efficacy of AviMatrix� (benzoic acid, calcium formate and fumaric acid) for chickens for fattening, chickens reared for laying, minor avian species for fattening and minor avian species reared to point of lay View page or View pdf |
| Safety and efficacy of a feed additive consisting of a preparation of benzoic acid, calcium formate and fumaric acid (AviMatrix Z) for all avian species other than laying birds (Novus Europe S.A. / N.V) View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):110-17-8 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :723 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| (2E)-but-2-enedioic acid |
| Chemidplus:0000110178 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:110-17-8 |
| (2E)-but-2-enedioic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 110-17-8 |
| Pubchem (cid): | 723 |
| Pubchem (sid): | 134974177 |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00122 |
| HMDB (The Human Metabolome Database): | HMDB00134 |
| FooDB: | FDB003291 |
| YMDB (Yeast Metabolome Database): | YMDB00101 |
| Export Tariff Code: | 2917.19.1700 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| FAO: | FUMARIC ACID |
| FAO: | Fumaric acid |
| None Found |
| buffering agents |
| boletic acid | |
| (2E)- | but-2-enedioic acid |
| (E)- | but-2-enedioic acid |
| trans- | but-2-enedioic acid |
| (E)- | butene dioic acid |
| (2E)-2- | butenedioic acid |
| (E)- | butenedioic acid |
| (E)-2- | butenedioic acid |
| trans-2- | butenedioic acid |
| 2- | butenedioic acid (2E)- |
| 2- | butenedioic acid, (2E)- |
| butenedioic acid, (E)- | |
| 2- | butenedioic acid, (E)- |
| trans-1,2- | ethenedicarboxylic acid |
| 1,2- | ethenedicarboxylic acid, trans- |
| (E)-1,2- | ethylene dicarboxylic acid |
| alpha,beta- | ethylene-1,2-dicarboxylic acid |
| (E)-1,2- | ethylenedicarboxylic acid |
| trans-1,2- | ethylenedicarboxylic acid |
| fumaric acid FCC | |
| fumaric acid FCC powder cold water soluble CWS 31502 | |
| fumaric acid natural | |
| fumaric acid NF FCC granular FF | |
| fumaricacid | |
| fumarsaeure | |
| lichenic acid | |
| allo | maleic acid |
| allo- | maleic acid |
| allo- | malenic acid |
| (E)- | tumaric acid |
