| 2D: |  |
|---|---|
| 3D: | |
| CAS Number: | 104-55-2 |
| ECHA EC Number: | 203-213-9 |
| FDA UNII: | Search |
| CoE Number: | 102 |
| Category: | flavor and fragrance agents |
| IUPAC Name: | cinnamaldehyde |
| InChI : | InChI=1/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H |
| Std.InChI: | InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H |
| InChIKey : | KJPRLNWUNMBNBZ-UHFFFAOYAB |
| Std.InChIKey: | KJPRLNWUNMBNBZ-UHFFFAOYSA-N |
| SMILES : | C1=CC=C(C=C1)C=CC=O |
| MDL: | MFCD00007000 |
| Molar Refractivity : | 42.32 ± 0.3 cm3 (est) |
| Parachor : | 319.1 ± 4.0 cm3 (est) |
| Index of Refraction : | 1.577 ± 0.02 (est) |
| Surface Tension : | 38.9 ± 3.0 dyne/cm (est) |
| Density : | 1.034 ± 0.06 g/cm3 (est) |
| Polarizability : | 16.78 ± 0.5 10-24cm3 (est) |
| Fragrance Demo Formulas | |
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 656 cinnamaldehyde |
| DG SANTE Food Flavourings: | 05.014 cinnamaldehyde |
| FEMA Number: | 2286 cinnamaldehyde |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 104-55-2 ; CINNAMALDEHYDE |
| FDA Regulation: | |
| FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart A--General Provisions Sec. 182.60 Synthetic flavoring substances and adjuvants. | |
| Appearance: | pale yellow to dark yellow clear oily liquid (est) |
| Assay: | 98.00 to 100.00 sum of isomers |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 1.04600 to 1.05000 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 8.704 to 8.737 |
| Specific Gravity: | 1.05000 to 1.05800 @ 15.00 °C. |
| Pounds per Gallon - est.: | 8.755 to 8.822 |
| Refractive Index: | 1.61900 to 1.62300 @ 20.00 °C. |
| Melting Point: | -8.00 to -6.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 249.00 to 252.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 131.00 to 132.00 °C. @ 20.00 mm Hg |
| Acid Value: | 10.00 max. KOH/g |
| Vapor Pressure: | 0.026500 mmHg @ 25.00 °C. |
| Vapor Density: | 4.6 ( Air = 1 ) |
| Flash Point: | 200.00 °F. TCC ( 93.33 °C. ) |
| logP (o/w): | 1.900 |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store under nitrogen. |
| Storage: | refrigerate in tightly sealed containers. store under nitrogen. |
| Soluble in: | |
| ethyl alcohol, 1:25 in 30% alcohol | |
| ethyl alcohol, 1:5 in 60% alcohol | |
| ethyl alcohol, 2:5 in 70% alcohol | |
| ethyl alcohol, 5 vol. 60% alcohol | |
| water, 2150 mg/L @ 25 °C (est) | |
| water, 1420 mg/L @ 25 °C (exp) | |
| Insoluble in: | |
| paraffin oil | |
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 21/41 - Harmful in contact with skin, risk of serious damage to eyes. R 38 - Irritating to skin. R 43 - May cause sensitisation by skin contact. S 02 - Keep out of the reach of children. S 24 - Avoid contact with skin. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| Flammable liquids (Category 4), H227 Skin irritation (Category 2), H315 Skin sensitisation (Category 1), H317 Eye irritation (Category 2A), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 | |
| GHS Label elements, including precautionary statements | |
| Pictogram |  |
| Signal word | Warning |
| Hazard statement(s) | |
| H227 - Combustible liquid H315 - Causes skin irritation H317 - May cause an allergic skin reaction H319 - Causes serious eye irritation H335 - May cause respiratory irritation | |
| Precautionary statement(s) | |
| P210 - Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P264 - Wash skin thouroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P272 - Contaminated work clothing should not be allowed out of the workplace. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P302 + P352 - IF ON SKIN: wash with plenty of soap and water. P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 - Call a POISON CENTER or doctor/physician if you feel unwell. P333 + P313 - IF SKIN irritation or rash occurs: Get medical advice/attention. P337 + P313 - IF eye irritation persists: Get medical advice/attention. P362 - Take off contaminated clothing and wash before reuse. P370 + P378 - In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction. P403 + P233 - Store in a well-ventilated place. Keep container tightly closed. P403 + P235 - Store in a well-ventilated place. Keep cool. P405 - Store locked up. P501 - Dispose of contents/ container to an approved waste disposal plant. | |
| Human Experience: | |
| 8 % solution: skin irritation. 2 % solution: sensitising. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 2220 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-mouse LD50 2225 mg/kg BEHAVIORAL: ATAXIABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Yakugaku Zasshi. Journal of Pharmacy. Vol. 92, Pg. 135, 1972. intravenous-mouse LD50 75 mg/kg U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07571 intraperitoneal-mouse LD50 200 mg/kg FAO Nutrition Meetings Report Series. Vol. 44A, Pg. 16, 1967. oral-guinea pig LD50 1160 mg/kg BEHAVIORAL: COMA Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. parenteral-mouse LDLo 200 mg/kg "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 687, 1955. | |
| Dermal Toxicity: | |
| skin-rabbit LD50 0.59 ml/kg "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 7, Pg. 687, 1955. | |
| Inhalation Toxicity: | |
| Not determined | |
| Category: | |||
| flavor and fragrance agents | |||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| IFRA Critical Effect: | |||
| Dermal sensitization and systemic toxicity | |||
| IFRA fragrance material specification: | |||
| The concentration of Cinnamic aldehyde in the finished cosmeticproduct should not exceed 0.1%. | |||
| View the IFRA Standard | |||
| View IFRA Standards Library for complete information. | |||
| Please review Amendment 49 IFRA documentation for complete information. | |||
| IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%): | |||
| Category 1: Products applied to the lips | |||
| 0.045 % | |||
| Category 2: Products applied to the axillae | |||
| 0.014 % | |||
| Category 3: Products applied to the face/body using fingertips | |||
| 0.021 % | |||
| Category 4: Products related to fine fragrance | |||
| 0.25 % | |||
| Category 5: Products applied to the face and body using the hands (palms), primarily leave-on | |||
| Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on | |||
| 0.064 % | |||
| Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on | |||
| 0.042 % | |||
| Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on | |||
| 0.064 % | |||
| Category 5D: Baby Creams, baby Oils and baby talc | |||
| 0.014 % | |||
| Category 6: Products with oral and lip exposure | |||
| 0.15 % | |||
| Category 7: Products applied to the hair with some hand contact | |||
| Category 7A: Rinse-off products applied to the hair with some hand contact | |||
| 0.17 % | |||
| Category 7B: Leave-on products applied to the hair with some hand contact | |||
| 0.17 % | |||
| Category 8: Products with significant anogenital exposure | |||
| 0.014 % | |||
| Category 9: Products with body and hand exposure, primarily rinse off | |||
| 0.49 % | |||
| Category 10: Household care products with mostly hand contact | |||
| Category 10A: Household care excluding aerosol products (excluding aerosol/spray products) | |||
| 0.49 % | |||
| Category 10B: Household aerosol/spray products | |||
| 1.80 % | |||
| Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate | |||
| Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure | |||
| 0.014 % | |||
| Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure | |||
| 0.014 % | |||
| Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin | |||
| No Restriction | |||
| Notes: | |||
| IFRA FLAVOR REQUIREMENTS: | |||
Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 2100.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 59000.00 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 180.00000 | |
| beverages(nonalcoholic): | - | 9.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | 4900.00000 | |
| condiments / relishes: | - | 20.00000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 7.70000 | |
| fruit ices: | - | 7.70000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 700.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | 60.00000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Flavouring Group Evaluation 214: alpha,beta-Unsaturated aldehydes and precursors from chemical subgroup 3.1 of FGE.19: Cinnamyl derivatives[1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 68 (FGE.68): Consideration of cinnamyl alcohol and related flavouring agents evaluated by JECFA (55th meeting) evaluated by EFSA in FGE.15Rev1 (2008) View page or View pdf |
| Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy View page or View pdf |
| Safety and efficacy of aryl-substituted primary alcohol, aldehyde, acid, ester and acetal derivatives belonging to chemical group 22 when used as flavourings for all animal species View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):104-55-2 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :307 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WISER:UN 2810 |
| WGK Germany:1 |
| 3-phenylprop-2-enal |
| Chemidplus:0000104552 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:GD6475000 for cas# 104-55-2 |
| 3-phenylprop-2-enal | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 104-55-2 |
| Pubchem (cid): | 307 |
| Pubchem (sid): | 134972883 |
| Pherobase: | View |
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00903 |
| HMDB (The Human Metabolome Database): | HMDB03441 |
| FooDB: | FDB008781 |
| YMDB (Yeast Metabolome Database): | YMDB01654 |
| Export Tariff Code: | 2912.29.6000 |
| Typical G.C. | |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| FR | allspice |
| FR | almond |
| FR | apple |
| FR | apricot |
| aramis | |
| FR | balsam |
| FR | banana |
| brut | |
| FR | bubble gum |
| FR | butterscotch |
| canoe | |
| FR | carnation |
| FR | cassia |
| FL | catsup |
| FR | cherry |
| FL | cherry wild cherry |
| FL | chocolate cacao |
| cinnabar | |
| FR | cinnamon |
| FL | cola |
| FR | cranberry |
| FR | date |
| FR | floral |
| FR | florida soap |
| FR | foliage |
| FL | grenadine |
| halston | |
| FR | herbal |
| FR | hyacinth |
| l'air du temps | |
| l'origan | |
| FR | millefleurs |
| FR | mint |
| FR | myrrh |
| norell | |
| old spice | |
| opium | |
| FR | oriental |
| paco rabanne | |
| FR | patchouli |
| pierre cardin | |
| FR | plum |
| FR | potpourri |
| FR | raspberry |
| FR | rose |
| FR | sassafras |
| sensen | |
| FL | sesame |
| FR | spice |
| FR | strawberry |
| FR | tonka bean |
| FR | tuberose |
| FL/FR | valerian |
| FR | vanilla |
| FR | windsor soap |
| youth dew |
| allspice plant Search Trop Picture | |
| anise seed oil Search Trop Picture | |
| apple fruit Search Trop Picture | |
| bilberry fruit Search Trop Picture | |
| bilberry leaf Search Trop Picture | |
| cassia Search PMC Picture | |
| cassia bark Search Trop Picture | |
| celery seed oil Search Trop Picture | |
| champaca concrete @ 0.02% Data GC Search Trop Picture | |
| cinnamomum cassia b. 80-95% leaves Search Trop Picture | |
| cinnamomum laureiri n. stems and roots Search Trop Picture | |
| cinnamomum zeylanicum b. 70-75% Search Trop Picture | |
| cinnamon bark Search Trop Picture | |
| cinnamon ceylon cinnamon Search Trop Picture | |
| cinnamon ceylon cinnamon bark Search Trop Picture | |
| cinnamon ceylon cinnamon bark oil Search Trop Picture | |
| cinnamon ceylon cinnamon leaf oil Search Trop Picture | |
| cinnamon ceylon cinnamon oil Search Trop Picture | |
| cinnamon ceylon cinnamon root Search Trop Picture | |
| cinnamon ceylon cinnamon root bark Search Trop Picture | |
| cinnamon ceylon cinnamon stem bark Search Trop Picture | |
| cinnamon indonesian cinnamon b. 77-80% Search Trop Picture | |
| cinnamon leaf Search Trop Picture | |
| cinnamon oil CO2 extract @ 77.24-81.47% Data GC Search Trop Picture | |
| cinnamon root Search PMC Picture | |
| clove fruit Search Trop Picture | |
| clove stem Search Trop Picture | |
| cranberry fruit Search Trop Picture | |
| fig fruit Search Trop Picture | |
| grape fruit Search Trop Picture | |
| hedychium spicatum h. rhizomes Search Trop Picture | |
| hyacinth Search Trop Picture | |
| hyacinthus orientalis absolute @ trace% Data GC Search Trop Picture | |
| lemon balm Search Trop Picture | |
| metaleuca bracteata Search Trop Picture | |
| myrrha slecta h. Search Trop Picture | |
| narcissus absolute @ 0.05% Data GC Search Trop Picture | |
| patchouli Search Trop Picture | |
| rose Search PMC Picture | |
| styrax Search Picture | |
| tamarind fruit Search Trop Picture | |
| thevetia peruviana (pers.) k. schum. flower oil brazil @ 0.70% Data GC Search Trop Picture | |
| tolu balsam Search Trop Picture | |
| tomato fruit Search Trop Picture | |
| ylang ylang oil CO2 extract @ 0.21% Data GC Search Trop Picture |
| benzylidene acetaldehyde | |
| cassia aldehyde | |
| cinnamal | |
| cinnamaldehyde | |
| cinnamaldehyde (ex cinnamon) | |
| cinnamaldehyde (natural) | |
| cinnamaldehyde natural | |
| cinnamic aldehyde | |
| nat. | cinnamic aldehyde |
| cinnamic aldehyde china, natural isolated constituent | |
| cinnamic aldehyde FCC | |
| cinnamic aldehyde nat FCC | |
| cinnamic aldehyde natural | |
| cinnamic aldehyde, natural | |
| cinnamyl aldehyde | |
| phenyl acrolein | |
| 3- | phenyl acrolein |
| beta- | phenyl acrolein |
| 3- | phenyl acryl aldehyde |
| 3- | phenyl acrylaldehyde |
| 3- | phenyl propen-1-al |
| 3- | phenyl propenal |
| 3- | phenyl-2-propen-1-al |
| 3- | phenyl-2-propenal |
| 3- | phenyl-2-propenaldehyde |
| 3- | phenylacrylaldehyde |
| 3- | phenylprop-2-enal |
| 2- | propenal, 3-phenyl- |
| zimtaldehyde |
| Info:Cinnamaldehyde |
